Safety and toxicological evaluation of AlgaeCal® (AC), a novel plant-based calcium supplement

Toxicology Mechanisms and Methods

Volumn 20, Issue 6, 2010, Pages 334-344

  Marone, Palma Ann ^a   Yasmin, Taharat ^b   Gupta, Ramesh C ^c   Bagchi, Manashi ^d  

^a Eurofins Medinet Inc   (Germany)

^b CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^c MURRAY STATE UNIVERSITY   (United States)

^d NutriToday   (United States)

Author keywords

Acute dermal toxicity; Acute oral toxicity; AlgaeCal ; Plant based calcium supplement; Pre natal developmental toxicity; Primary eye irritation; Primary skin irritation

Indexed keywords

ALGAECAL; CALCIUM DERIVATIVE; DN0361; MAGNESIUM; UNCLASSIFIED DRUG;

ALGA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; EXPOSURE; EYE IRRITATION; EYE TOXICITY; FEMALE; INCIDENCE; LD 50; MALE; NONHUMAN; OSSIFICATION; PILOT STUDY; PREGNANCY; PRIORITY JOURNAL; RAT; SKIN IRRITATION; SKIN TOXICITY; TERATOGENICITY; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ALGAE; ANIMALS; BODY WEIGHT; CALCIUM; CONSUMER PRODUCT SAFETY; DIETARY SUPPLEMENTS; EYE; FEMALE; MALE; ORGAN SPECIFICITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SKIN; TOXICITY TESTS;

ALGAE; RATTUS; STERNA;

EID: 77953747983     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.490966     Document Type: Article

References (13)

1. Adluri RS, Zhan L, Bagchi M, Maulik N, Maulik G. (in press) Comparative effects of a novel plant-based calcium supplement with two common calcium salts on proliferation and mineralization in human osteoblast cells. Mol Cell Biochem [Epub ahead of print].
2. Draize JH, Woodward G, Calvery HO. 1944. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membrane. J Pharmacol Exp Ther 82:377-390.
3. Dunnett CW. 1955. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121.
4. FDA. 1987. Good Laboratory Practices (GLP) for Non-Clinical Laboratory Studies. In: Services. D. o. H. a. H. Washington, DC. US Food and Drug Administration. pp. 297-310.
5. George JD, Price CJ, Marr MC, Myers CB, Schwetz BA, Heindel JJ, Hunter SH. 1996. Evaluation of the developmental toxicity of methacrylnitrile in Sprague-Dawley rats and New Zealand white rabbits. Fundam Appl Toxicol 34:249-259.
6. Kay JH, Calandra JC. 1962. Interpretation of eye irritation tests. J Soc Cos Chem 13:281-289.
7. Morgan SL. 2009. Nutrition and bone: it is more than calcium and vitamin D. Womens Health (Lond Engl) 5:727-737.
8. OECD. 1998. Paris: Committee, C. G. a. M. Principles of Good Laboratory Practice Organization for Economic Cooperation and Development.
9. Scott JC. 1997. Epidemiology of osteoporosis. J Clin Rheumatol 3:9-13.
10. Snedecor GW, Cochran WG. 1989. Statistical methods. 8th ed. Ames, IA: Iowa State Press.
11. Steel RGD, Torrie JH. 1980. Principles and procedures of statistics. A biometrical approach. 2nd ed. New York, NY: McGraw-Hill.
12. Uenishi K. 2009. Nutrition and bone health. Calcium intake and bone health. Clin Calcium 19:1664-1669.
13. Verhaar HJ. 2009. Medical treatment of osteoporosis in the elderly. Aging Clin Exp Res 21:407-413.