Safety and toxicological evaluation of a novel chromium(III) dinicocysteinate complex

Toxicology Mechanisms and Methods

Volumn 20, Issue 6, 2010, Pages 321-333

  Sreejayan, Nair ^a   Marone, Palma Ann ^b   Lau, Francis C ^c   Yasmin, Taharat ^d   Bagchi, Manashi ^c   Bagchi, Debasis ^c,e  

^a UNIVERSITY OF WYOMING   (United States)

^b Eurofins Medinet Inc   (Germany)

^c InterHealth Nutraceuticals Inc   (United States)

^d CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF HOUSTON   (United States)

Author keywords

90 day dose dependent oral toxicity; Acute oral and dermal toxicity; Ames' bacterial reverse mutation assay; Chromium(III); Mammalian erythrocyte micronucleus test; Primary skin and eye irritation

Indexed keywords

CHROMIUM DERIVATIVE; CHROMIUM DINICOCYSTEINATE; CYSTEINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVALUATION; EYE IRRITATION; EYE TOXICITY; FEMALE; HISTOPATHOLOGY; MALE; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SAFETY; SKIN IRRITATION; SKIN TOXICITY; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANIMALS; BODY WEIGHT; CHROMIUM; CONSUMER PRODUCT SAFETY; CYSTEINE; EYE; FEMALE; MALE; MOTOR ACTIVITY; MUTAGENICITY TESTS; ORGAN SIZE; ORGAN SPECIFICITY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SKIN; SKIN IRRITANCY TESTS; TOXICITY TESTS; TOXICITY TESTS, CHRONIC;

BACTERIA (MICROORGANISMS); MAMMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 77953745559     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.487880     Document Type: Article

References (30)

1. Ames BN, Durston WE, Yamasaki E, Lee FD. 1973. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria detection. Proc Natl Acad Sci USA 70:2281-2285.
2. Anderson RA. 1998. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 17:548-555.
3. Anderson RA, Mertz W. 1977. Glucose tolerance factor: an essential dietary agent. Trends Biochem Sci 2:277-279.
4. Bagchi D, Balmoori J, Bagchi M, Ye X, Williams CB, Stohs SJ. 2000a. Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice. Free Radic Biol Med 28:895-903.
5. Bagchi D, Joshi SS, Bagchi M, Balmoori J, Benner EJ, Kuszynski CA, Stohs SJ. 2000b. Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. J Biochem Mol Toxicol 14:33-41.
6. Barrett J, O'Brien P, Jesus J. 1985. Chromium(III) and the glucose tolerance factor. Polyhedron 4:1-14.
7. Bunker VW, Lawson MS, Delves HT, Clayton BE. 1984. The uptake and excretion of chromium by the elderly. Am J Clin Nutr 39:797-802.
8. Cooper J, Blackwell L, Buckley P. 1984. Chromium (III) complexes and their relationship to the glucose tolerance factor. Part II. Structure and biological activity of amino acid complexes. Inorg Chim Acta 92:23-31
9. Crawford V, Scheckenbach R, Preuss HG. 1999. Effects of niacin-bound chromium supplementation on body composition in overweight African-American women. Diab Obes Metab 1:331-337.
10. Dowling HJ, Offenbacher EG, Pi-Sunyer FX. 1989. Absorption of inorganic, trivalent chromium from the vascularly perfused rat small intestine. J Nutr 119:1138-1145.
11. Draize JH, Woodward G, Calvery HO. 1944. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 82:377-390.
12. Febel HB, Szegedi B, Huszar S. 2001. Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats. Acta Vet Hung 49:203-209.
13. Freund, H, Atamian S, Fischer JE. 1979. Chromium deficiency during total parenteral nutrition. JAMA 241:496-498.
14. Grant KE, Chandler RM, Castle AL, Ivy JL. 1997. Chromium and exercise training: effect on obese women. Med Sci Sports Exerc 29:992-998.
15. Hummel M, Standl E, Schnell O. 2007. Chromium in metabolic and cardiovascular disease. Horm Metab Res 39:743-751.
16. Kay JH, Calandra JC. 1962. Interpretation of eye irritation tests. J Soc Cos Chem 13:281-289.
17. Lau FC, Bagchi M, Sen CK, Bagchi D. 2008. Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes. Mol Cell Biochem 317:1-10.
18. Lefavi RG, Wilson GD, Keith RE, Anderson RA, Blessing DL, Hames CG, McMillan JL. 1993. Lipid lowering effect of dietary chromium (III)-nicotinic acid complex in male athletes. Nutr Res 13:239-249.
19. Lukaski HC. 1999. Chromium as a supplement. Annu Rev Nutr 19:279-302.
20. Mark DA.2006. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes: response to Martin et al. Diabetes Care 29:2764; author reply 2764-2765.
21. Mertz W. 1969. Chromium occurrence and function in biological systems. Physiol Rev 49:163-239.
22. Mertz W. 1993. Chromium in human nutrition: a review. J Nutr 123: 626-633.
23. Olin KL, Stearns DM, Armstrong WH, Keen CL. 1994. Comparative retention/ absorption of 51chromium (51Cr) from 51Cr chloride, 51Cr nicotinate and 51Cr picolinate in a rat model. Trace Elem Electrolytes 11:182-186.
24. Preuss HG, Grojec PL, Lieberman S, Anderson RA. 1997. Effects of different chromium compounds on blood pressure and lipid peroxidation in spontaneously hypertensive rats. Clin Nephrol 47:325-330.
25. Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D. 2001. Longterm effects of chromium, grape seed extract, and zinc on various metabolic parameters of rats. Mol Cell Biochem 223:95-102.
26. Rajpathak S, Rimm EB, Li T, Morris JS, Stampfer MJ, Willett WC, Hu FB. 2004. Lower toenail chromium in men with diabetes and cardiovascular disease compared with healthy men. Diabetes Care 27:2211-2216.
27. Toepfer EW, Mertz W, Polansky MM, Roginski EE, Wolf WR. 1976. Preparation of chromium-containing material of glucose tolerance factor activity from brewer's yeast extracts and by synthesis. J Agric Food Chem 25:162-166.
28. Vincent JB. 1999. Mechanisms of chromium action: low-molecular-weight chromiumbinding substance. J Am Coll Nutr 18:6-12.
29. Yamamoto A, Wada O, Ono T. 1984. Distribution and chromium-binding capacity of a low-molecular-weight, chromium-binding substance in mice. J Inorg Biochem 22:91-102
30. Yamamoto A, Wada O, Ono T. 1987. Isolation of a biologically active lowmolecular-mass chromium compound from rabbit liver. Eur J Biochem 165:627-631.