메뉴 건너뛰기




Volumn 9, Issue 75, 2012, Pages 2723-2734

Optimal homeostasis necessitates bistable control

Author keywords

AKT; Bistability; Glucose insulin feedback system; Homeostasis; Insulin signalling pathway; Optimal control

Indexed keywords

GLUCOSE; INSULIN; NUTRITION; OPTICAL BISTABILITY; OPTIMIZATION;

EID: 84866245734     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2012.0244     Document Type: Article
Times cited : (15)

References (67)
  • 1
    • 79960251114 scopus 로고    scopus 로고
    • Dynamical systems theory in physiology
    • doi:10.1085/jgp.201110668
    • Sherman, A. 2011 Dynamical systems theory in physiology. J. Gen. Physiol. 138, 13-19. (doi:10.1085/jgp.201110668)
    • (2011) J. Gen. Physiol. , vol.138 , pp. 13-19
    • Sherman, A.1
  • 2
    • 0001389945 scopus 로고
    • Enzyme induction as an all-or-none phenomenon
    • doi:10.1073/pnas.43.7.553
    • Novick, A. & Weiner, M. 1957 Enzyme induction as an all-or-none phenomenon. Proc. Natl Acad. Sci. USA 43, 553-566. (doi:10.1073/pnas.43.7.553)
    • (1957) Proc. Natl Acad. Sci. USA , vol.43 , pp. 553-566
    • Novick, A.1    Weiner, M.2
  • 3
    • 46249121558 scopus 로고    scopus 로고
    • Quantitative approaches to the study of bistability in the lac operon of Escherichia coli
    • doi:10.1098/rsif.2008.0086.focus
    • Santillán, M. & Mackey, M. C. 2008 Quantitative approaches to the study of bistability in the lac operon of Escherichia coli. J. R. Soc. Interface 5(Suppl. 1), S29-S39. (doi:10.1098/rsif.2008.0086.focus)
    • (2008) J. R. Soc. Interface , vol.5 , Issue.SUPPL. 1
    • Santillán, M.1    Mackey, M.C.2
  • 4
    • 0032496358 scopus 로고    scopus 로고
    • The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
    • doi:10.1126/science.280.5365.895
    • Ferrell Jr, J. E. & Machleder, E. M. 1998 The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895-898. (doi:10.1126/science.280.5365.895)
    • (1998) Science , vol.280 , pp. 895-898
    • Ferrell Jr., J.E.1    Machleder, E.M.2
  • 5
    • 0037417803 scopus 로고    scopus 로고
    • Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts
    • doi:10.1073/pnas.0235349100
    • Sha, W., Moore, J., Chen, K., Lassaletta, A. D., Yi, C.-S., Tyson, J. J. & Sible, J. C. 2003 Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc. Natl Acad. Sci. USA 100, 975-980. (doi:10.1073/pnas.0235349100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 975-980
    • Sha, W.1    Moore, J.2    Chen, K.3    Lassaletta, A.D.4    Yi, C.-S.5    Tyson, J.J.6    Sible, J.C.7
  • 6
    • 1242274449 scopus 로고    scopus 로고
    • Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
    • doi:10.1073/pnas.0308265100
    • Angeli, D., Ferrell Jr, J. E. & Sontag, E. D. 2004 Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc. Natl Acad. Sci. USA 101, 1822-1827. (doi:10.1073/pnas.0308265100)
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1822-1827
    • Angeli, D.1    Ferrell Jr., J.E.2    Sontag, E.D.3
  • 7
    • 78649786267 scopus 로고    scopus 로고
    • Non-equilibrium phase transition in mesoscopic biochemical systems: From stochastic to nonlinear dynamics and beyond
    • doi:10.1098/rsif.2010.0202
    • Ge, H. & Qian, H. 2011 Non-equilibrium phase transition in mesoscopic biochemical systems: from stochastic to nonlinear dynamics and beyond. J. R. Soc. Interface 8, 107-116. (doi:10.1098/rsif.2010.0202)
    • (2011) J. R. Soc. Interface , vol.8 , pp. 107-116
    • Ge, H.1    Qian, H.2
  • 8
    • 68849093960 scopus 로고    scopus 로고
    • Stochastic bifurcation, slow fluctuations, and bistability as an origin of biochemical complexity
    • doi:10.1039/b900335p
    • Qian, H., Shi, P.-Z. & Xing, J. 2009 Stochastic bifurcation, slow fluctuations, and bistability as an origin of biochemical complexity. Phys. Chem. Chem. Phys. 11, 4861-4870. (doi:10.1039/b900335p)
    • (2009) Phys. Chem. Chem. Phys. , vol.11 , pp. 4861-4870
    • Qian, H.1    Shi, P.-Z.2    Xing, J.3
  • 9
    • 74049092279 scopus 로고    scopus 로고
    • Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase
    • doi:10.1016/j.bpj.2009.09.055
    • Bishop, L. M. & Qian, H. 2010 Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase. Biophys. J. 98, 1-11. (doi:10.1016/j.bpj.2009.09.055)
    • (2010) Biophys. J. , vol.98 , pp. 1-11
    • Bishop, L.M.1    Qian, H.2
  • 10
    • 69949088230 scopus 로고    scopus 로고
    • Stochastic dynamics and non-equilibrium thermodynamics of a bistable chemical system: The Schlögl model revisited
    • doi:10.1098/rsif.2008.0476
    • Vellela, M. & Qian, H. 2009 Stochastic dynamics and non-equilibrium thermodynamics of a bistable chemical system: the Schlögl model revisited. J. R. Soc. Interface 6, 925-940. (doi:10.1098/rsif.2008.0476)
    • (2009) J. R. Soc. Interface , vol.6 , pp. 925-940
    • Vellela, M.1    Qian, H.2
  • 11
    • 0345700833 scopus 로고    scopus 로고
    • Building a cell cycle oscillator: Hysteresis and bistability in the activation of Cdc2
    • doi:10.1038/ncb954
    • Pomerening, J. R., Sontag, E. D. & Ferrell Jr, J. E. 2003 Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat. Cell Biol. 5, 346-351. (doi:10.1038/ncb954)
    • (2003) Nat. Cell Biol. , vol.5 , pp. 346-351
    • Pomerening, J.R.1    Sontag, E.D.2    Ferrell Jr., J.E.3
  • 12
    • 0036156035 scopus 로고    scopus 로고
    • Testing a mathematical model of the yeast cell cycle
    • doi:10.1091/mbc.01-05-0265
    • Cross, F. R., Archambault, V., Miller, M. & Klovstad, M. 2002 Testing a mathematical model of the yeast cell cycle. Mol. Biol. Cell 13, 52-70. (doi:10.1091/mbc.01-05-0265)
    • (2002) Mol. Biol. Cell , vol.13 , pp. 52-70
    • Cross, F.R.1    Archambault, V.2    Miller, M.3    Klovstad, M.4
  • 13
    • 77955791932 scopus 로고    scopus 로고
    • Computational analysis of mTOR signaling pathway: Bifurcation, carcinogenesis, and drug discovery
    • Wang, G. & Krueger, G. R. F. 2010 Computational analysis of mTOR signaling pathway: bifurcation, carcinogenesis, and drug discovery. Anticancer Res. 30, 2683-2688.
    • (2010) Anticancer Res. , vol.30 , pp. 2683-2688
    • Wang, G.1    Krueger, G.R.F.2
  • 14
    • 79551478205 scopus 로고    scopus 로고
    • Singularity analysis of the AKT signaling pathway reveals connections between cancer and metabolic diseases
    • doi:10.1088/1478-3975/7/4/046015
    • Wang, G. 2010 Singularity analysis of the AKT signaling pathway reveals connections between cancer and metabolic diseases. Phys. Biol. 7, 046015. (doi:10.1088/1478-3975/7/4/046015)
    • (2010) Phys. Biol. , vol.7 , pp. 046015
    • Wang, G.1
  • 15
    • 15444368455 scopus 로고    scopus 로고
    • A steady state analysis indicates that negative feedback regulation of PTP1B by AKT elicits bistability in insulin-stimulated GLUT4 translocation
    • doi:10.1186/1742-4682-1-2
    • Giri, L., Mutalik, V. K. & Venkatesh, K. V. 2004 A steady state analysis indicates that negative feedback regulation of PTP1B by AKT elicits bistability in insulin-stimulated GLUT4 translocation. Theor. Biol. Med. Model. 1, 2. (doi:10.1186/1742-4682-1-2)
    • (2004) Theor. Biol. Med. Model. , vol.1 , pp. 2
    • Giri, L.1    Mutalik, V.K.2    Venkatesh, K.V.3
  • 16
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • doi:10.1038/35002131
    • Gardner, T. S., Cantor, C. R. & Collins, J. J. 2000 Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342. (doi:10.1038/35002131)
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 17
  • 18
    • 0010424768 scopus 로고
    • A mechanism for memory storage insensitive to molecular turnover: A bistable autophosphorylating kinase
    • doi:10.1073/pnas.82.9.3055
    • Lisman, J. E. 1985 A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase. Proc. Natl Acad. Sci. USA 82, 3055-3057. (doi:10.1073/pnas.82.9.3055)
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3055-3057
    • Lisman, J.E.1
  • 19
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable 'memory module' that governs a cell fate decision
    • doi:10.1038/nature02089
    • Xiong, W. & Ferrell Jr, J. E. 2003 A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 426, 460-465. (doi:10.1038/nature02089)
    • (2003) Nature , vol.426 , pp. 460-465
    • Xiong, W.1    Ferrell Jr., J.E.2
  • 20
    • 71149116962 scopus 로고    scopus 로고
    • System-level feedbacks control cell cycle progression
    • doi:10.1016/j.febslet.2009.08.023
    • Kapuy, O., He, E., López-Avilés, S., Uhlmann, F., Tyson, J. J. & Novák, B. 2009 System-level feedbacks control cell cycle progression. FEBS Lett. 583, 3992-3998. (doi:10.1016/j.febslet.2009.08.023)
    • (2009) FEBS Lett. , vol.583 , pp. 3992-3998
    • Kapuy, O.1    He, E.2    López-Avilés, S.3    Uhlmann, F.4    Tyson, J.J.5    Novák, B.6
  • 21
    • 35748935235 scopus 로고    scopus 로고
    • Proteins, drug targets and the mechanisms they control: The simple truth about complex networks
    • doi:10.1038/nrd2381
    • Araujo, R. P., Liotta, L. A. & Petricoin, E. F. 2007 Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nat. Rev. Drug Discov. 6, 871-880. (doi:10.1038/nrd2381)
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 871-880
    • Araujo, R.P.1    Liotta, L.A.2    Petricoin, E.F.3
  • 22
    • 50349087322 scopus 로고    scopus 로고
    • Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch
    • doi:10.1529/biophysj.107.120600
    • Palani, S. & Sarkar, C. A. 2008 Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch. Biophys. J. 95, 1575-1589. (doi:10.1529/biophysj.107. 120600)
    • (2008) Biophys. J. , vol.95 , pp. 1575-1589
    • Palani, S.1    Sarkar, C.A.2
  • 23
    • 3142592406 scopus 로고    scopus 로고
    • Bio-switches: What makes them robust?
    • doi:10.1016/j.gde.2004.05.001
    • Slepchenko, B. M. & Terasaki, M. 2004 Bio-switches: what makes them robust? Curr. Opin. Genet. Dev. 14, 428-434. (doi:10.1016/j.gde.2004.05.001)
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 428-434
    • Slepchenko, B.M.1    Terasaki, M.2
  • 24
    • 79952754267 scopus 로고    scopus 로고
    • Bistability and oscillations in gene regulation mediated by small noncoding RNAs
    • doi:10.1371/journal.pone.0017029
    • Liu, D., Chang, X., Liu, Z., Chen, L. & Wang, R. 2011 Bistability and oscillations in gene regulation mediated by small noncoding RNAs. PLoS ONE 6, e17029. (doi:10.1371/journal.pone.0017029)
    • (2011) PLoS ONE , vol.6
    • Liu, D.1    Chang, X.2    Liu, Z.3    Chen, L.4    Wang, R.5
  • 25
    • 46849090495 scopus 로고    scopus 로고
    • Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    • doi:10.1126/science.1156951
    • Tsai, T. Y.-C., Choi, Y. S., Ma, W., Pomerening, J. R., Tang, C. & Ferrell Jr, J. E. 2008 Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science 321, 126-129. (doi:10.1126/ science.1156951)
    • (2008) Science , vol.321 , pp. 126-129
    • Tsai, T.Y.-C.1    Choi, Y.S.2    Ma, W.3    Pomerening, J.R.4    Tang, C.5    Ferrell Jr., J.E.6
  • 26
    • 78049263544 scopus 로고    scopus 로고
    • Large-scale analysis of network bistability for human cancers
    • doi:10.1371/journal.pcbi.1000851
    • Shiraishi, T., Matsuyama, S. & Kitano, H. 2010 Large-scale analysis of network bistability for human cancers. PLoS Comput. Biol. 6, e1000851. (doi:10.1371/journal.pcbi.1000851)
    • (2010) PLoS Comput. Biol. , vol.6
    • Shiraishi, T.1    Matsuyama, S.2    Kitano, H.3
  • 27
    • 21344487533 scopus 로고    scopus 로고
    • The best solution
    • doi:10.1038/435569a
    • Sutherland, W. J. 2005 The best solution. Nature 435, 569. (doi:10.1038/435569a)
    • (2005) Nature , vol.435 , pp. 569
    • Sutherland, W.J.1
  • 28
    • 0000733534 scopus 로고
    • Organization for physiological homeostasis
    • Cannon, W. B. 1929 Organization for physiological homeostasis. Physiol. Rev. 9, 399-431.
    • (1929) Physiol. Rev. , vol.9 , pp. 399-431
    • Cannon, W.B.1
  • 29
    • 0004224763 scopus 로고
    • New York, NY: W. W. Norton and Company, Inc.
    • Cannon, W. B. 1932 Wisdom of the body. New York, NY: W. W. Norton and Company, Inc.
    • (1932) Wisdom of the Body
    • Cannon, W.B.1
  • 30
    • 12344266697 scopus 로고    scopus 로고
    • How obesity causes diabetes: Not a tall tale
    • doi:10.1126/science.1104342
    • Lazar, M. A. 2005 How obesity causes diabetes: not a tall tale. Science 307, 373-375. (doi:10.1126/science.1104342)
    • (2005) Science , vol.307 , pp. 373-375
    • Lazar, M.A.1
  • 31
    • 0042234050 scopus 로고    scopus 로고
    • The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X
    • doi:10.1016/S0889-1591(03)00048-5
    • Black, P. H. 2003 The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav. Immun. 17, 350-364. (doi:10.1016/S0889-1591(03)00048-5)
    • (2003) Brain Behav. Immun. , vol.17 , pp. 350-364
    • Black, P.H.1
  • 32
    • 70349566593 scopus 로고
    • Diabetes mellitus: A 'thrifty' genotype rendered detrimental by 'progress'?
    • Neel, J. V. 1962 Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am. J. Hum. Genet. 14, 353-362.
    • (1962) Am. J. Hum. Genet. , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 33
    • 34748848090 scopus 로고    scopus 로고
    • Sitting on the horns of a dilemma: Avoiding severe hypoglycemia while practicing tight glycemic control
    • doi:10.1097/01.CCM.0000286520.50104.51
    • Nasraway Jr, S. A. 2007 Sitting on the horns of a dilemma: avoiding severe hypoglycemia while practicing tight glycemic control. Crit. Care Med. 35, 2435-2437. (doi:10.1097/01.CCM.0000286520.50104.51)
    • (2007) Crit. Care Med. , vol.35 , pp. 2435-2437
    • Nasraway Jr., S.A.1
  • 34
    • 0028816083 scopus 로고
    • Normalization of blood glucose in insulin-dependent diabetic pregnancies and the risks of hypoglycemia: A therapeutic dilemma
    • doi:10.1097/00006254-199501000-00027
    • Rosenn, B., Siddiqi, T. A. & Miodovnik, M. 1995 Normalization of blood glucose in insulin-dependent diabetic pregnancies and the risks of hypoglycemia: a therapeutic dilemma. Obstet. Gynecol. Surv. 50, 56-61. (doi:10.1097/00006254-199501000-00027)
    • (1995) Obstet. Gynecol. Surv. , vol.50 , pp. 56-61
    • Rosenn, B.1    Siddiqi, T.A.2    Miodovnik, M.3
  • 35
    • 1242273876 scopus 로고    scopus 로고
    • Insulin resistance and elevated triglyceride in muscle: More important for survival than 'thrifty' genes?
    • doi:10.1113/jphysiol.2003.053926
    • Stannard, S. R. & Johnson, N. A. 2004 Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty' genes? J. Physiol. (Lond.) 554, 595-607. (doi:10.1113/jphysiol.2003.053926)
    • (2004) J. Physiol. (Lond.) , vol.554 , pp. 595-607
    • Stannard, S.R.1    Johnson, N.A.2
  • 36
    • 0036306859 scopus 로고    scopus 로고
    • Positive and negative feedback: Striking a balance between necessary antagonists
    • doi:10.1006/jtbi.2002.2544
    • Cinquin, O. & Demongeot, J. 2002 Positive and negative feedback: striking a balance between necessary antagonists. J. Theor. Biol. 216, 229-241. (doi:10.1006/jtbi.2002.2544)
    • (2002) J. Theor. Biol. , vol.216 , pp. 229-241
    • Cinquin, O.1    Demongeot, J.2
  • 37
    • 34347353056 scopus 로고    scopus 로고
    • Function constrains network architecture and dynamics: A case study on the yeast cell cycle Boolean network
    • doi:10.1103/PhysRevE.75.051907
    • Lau, K.-Y., Ganguli, S. & Tang, C. 2007 Function constrains network architecture and dynamics: a case study on the yeast cell cycle Boolean network. Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 75, 051907. (doi:10.1103/ PhysRevE.75.051907)
    • (2007) Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. , vol.75 , pp. 051907
    • Lau, K.-Y.1    Ganguli, S.2    Tang, C.3
  • 40
    • 77953783859 scopus 로고    scopus 로고
    • Process-based network decomposition reveals backbone motif structure
    • doi:10.1073/pnas.0914180107
    • Wang, G., Du, C., Chen, H., Simha, R., Rong, Y., Xiao, Y. & Zeng, C. 2010 Process-based network decomposition reveals backbone motif structure. Proc. Natl Acad. Sci. USA 107, 10 478-10 483. (doi:10.1073/pnas.0914180107)
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10478-10483
    • Wang, G.1    Du, C.2    Chen, H.3    Simha, R.4    Rong, Y.5    Xiao, Y.6    Zeng, C.7
  • 41
    • 78449268845 scopus 로고    scopus 로고
    • Interdependence of cell growth and gene expression: Origins and consequences
    • doi:10.1126/science.1192588
    • Scott, M., Gunderson, C. W., Mateescu, E. M., Zhang, Z. & Hwa, T. 2010 Interdependence of cell growth and gene expression: origins and consequences. Science 330, 1099-1102. (doi:10.1126/science.1192588)
    • (2010) Science , vol.330 , pp. 1099-1102
    • Scott, M.1    Gunderson, C.W.2    Mateescu, E.M.3    Zhang, Z.4    Hwa, T.5
  • 42
    • 0004191820 scopus 로고    scopus 로고
    • 10th edn. Dubuque, IA: McGraw-Hill Science/Engineering/Math
    • Fox, S. 2007 Human physiology, 10th edn. Dubuque, IA: McGraw-Hill Science/Engineering/Math.
    • (2007) Human Physiology
    • Fox, S.1
  • 44
    • 0014041454 scopus 로고
    • A new method for the measurement in vitro of pancreatic insulin secretion
    • doi:10.1210/endo-80-1-99
    • Malaisse, W., Malaisse-Lagae, F. & Wright, P. H. 1967 A new method for the measurement in vitro of pancreatic insulin secretion. Endocrinology 80, 99-108. (doi:10.1210/endo-80-1-99)
    • (1967) Endocrinology , vol.80 , pp. 99-108
    • Malaisse, W.1    Malaisse-Lagae, F.2    Wright, P.H.3
  • 45
    • 0039829851 scopus 로고
    • Glucose stimulates proinsulin biosynthesis by a dosedependent recruitment of pancreatic beta cells
    • doi:10.1073/pnas.85.11.3865
    • Schuit, F. C., In't Veld, P. A. & Pipeleers, D. G. 1988 Glucose stimulates proinsulin biosynthesis by a dosedependent recruitment of pancreatic beta cells. Proc. Natl Acad. Sci. USA 85, 3865-3869. (doi:10.1073/pnas.85.11. 3865)
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 46
    • 0025718832 scopus 로고
    • Actively synthesizing beta-cells secrete preferentially after glucose stimulation
    • doi:10.1210/endo-129-6-3157
    • Bosco, D. & Meda, P. 1991 Actively synthesizing beta-cells secrete preferentially after glucose stimulation. Endocrinology 129, 3157-3166. (doi:10.1210/endo-129-6-3157)
    • (1991) Endocrinology , vol.129 , pp. 3157-3166
    • Bosco, D.1    Meda, P.2
  • 47
    • 0034699781 scopus 로고    scopus 로고
    • A model of beta-cell mass, insulin, and glucose kinetics: Pathways to diabetes
    • doi:10.1006/jtbi.2000.2150
    • Topp, B., Promislow, K., deVries, G., Miura, R. M. & Finegood, D. T. 2000 A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes. J. Theor. Biol. 206, 605-619. (doi:10.1006/jtbi.2000.2150)
    • (2000) J. Theor. Biol. , vol.206 , pp. 605-619
    • Topp, B.1    Promislow, K.2    DeVries, G.3    Miura, R.M.4    Finegood, D.T.5
  • 48
    • 0019810028 scopus 로고
    • Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
    • doi:10.1172/JCI110398
    • Bergman, R. N., Phillips, L. S. & Cobelli, C. 1981 Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J. Clin. Invest. 68, 1456-1467. (doi:10.1172/JCI110398)
    • (1981) J. Clin. Invest. , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, L.S.2    Cobelli, C.3
  • 49
    • 0025848683 scopus 로고
    • Computer model for mechanisms underlying ultradian oscillations of insulin and glucose
    • Sturis, J., Polonsky, K. S., Mosekilde, E. & Van Cauter, E. 1991 Computer model for mechanisms underlying ultradian oscillations of insulin and glucose. Am. J. Physiol. 260, E801-E809.
    • (1991) Am. J. Physiol. , vol.260
    • Sturis, J.1    Polonsky, K.S.2    Mosekilde, E.3    Van Cauter, E.4
  • 50
    • 0034619688 scopus 로고    scopus 로고
    • Modeling the insulin-glucose feedback system: The significance of pulsatile insulin secretion
    • doi:10.1006/jtbi.2000.2180
    • Tolić, I. M., Mosekilde, E. & Sturis, J. 2000 Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion. J. Theor. Biol. 207, 361-375. (doi:10.1006/jtbi.2000.2180)
    • (2000) J. Theor. Biol. , vol.207 , pp. 361-375
    • Tolić, I.M.1    Mosekilde, E.2    Sturis, J.3
  • 51
    • 33747876336 scopus 로고    scopus 로고
    • Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays
    • doi:10.1016/j.jtbi.2006.04.002
    • Li, J., Kuang, Y. & Mason, C. C. 2006 Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays. J. Theor. Biol. 242, 722-735. (doi:10.1016/j.jtbi.2006.04.002)
    • (2006) J. Theor. Biol. , vol.242 , pp. 722-735
    • Li, J.1    Kuang, Y.2    Mason, C.C.3
  • 54
    • 77953408308 scopus 로고    scopus 로고
    • Physiological regulation of AKT activity and stability
    • Liao, Y. & Hung, M.-C. 2010 Physiological regulation of AKT activity and stability. Am. J. Transl. Res. 2, 19-42.
    • (2010) Am. J. Transl. Res. , vol.2 , pp. 19-42
    • Liao, Y.1    Hung, M.-C.2
  • 55
    • 67650092976 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/AKT stability and activation phosphorylation
    • doi:10.1038/onc.2009.98
    • Liao, Y. et al. 2009 Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/AKT stability and activation phosphorylation. Oncogene 28, 2436-2445. (doi:10.1038/onc.2009.98)
    • (2009) Oncogene , vol.28 , pp. 2436-2445
    • Liao, Y.1
  • 56
    • 79954607087 scopus 로고    scopus 로고
    • Chronic heart failure reduces AKT phosphorylation in human skeletal muscle: Relationship to muscle size and function
    • doi:10.1152/japplphysiol.00545.2010
    • Toth, M. J., Ward, K., van der Velden, J., Miller, M. S., Vanburen, P., Lewinter, M. M. & Ades, P. A. 2011 Chronic heart failure reduces AKT phosphorylation in human skeletal muscle: relationship to muscle size and function. J. Appl. Physiol. 110, 892-900. (doi:10.1152/japplphysiol.00545.2010)
    • (2011) J. Appl. Physiol. , vol.110 , pp. 892-900
    • Toth, M.J.1    Ward, K.2    Van Der Velden, J.3    Miller, M.S.4    Vanburen, P.5    Lewinter, M.M.6    Ades, P.A.7
  • 58
    • 0023829632 scopus 로고
    • Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects
    • doi:10.1172/JCI113339
    • Polonsky, K. S., Given, B. D. & Van Cauter, E. 1988 Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81, 442-448. (doi:10.1172/JCI113339)
    • (1988) J. Clin. Invest. , vol.81 , pp. 442-448
    • Polonsky, K.S.1    Given, B.D.2    Van Cauter, E.3
  • 59
    • 0001424903 scopus 로고
    • An amplified sensitivity arising from covalent modification in biological systems
    • doi:10.1073/pnas.78.11.6840
    • Goldbeter, A. & Koshland Jr, D. E. 1981 An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl Acad. Sci. USA 78, 6840-6844. (doi:10.1073/pnas.78.11.6840)
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 6840-6844
    • Goldbeter, A.1    Koshland Jr., D.E.2
  • 60
    • 39749178412 scopus 로고    scopus 로고
    • Temporal cooperativity and sensitivity amplification in biological signal transduction
    • doi:10.1021/bi702125s
    • Qian, H. & Cooper, J. A. 2008 Temporal cooperativity and sensitivity amplification in biological signal transduction. Biochemistry 47, 2211-2220. (doi:10.1021/bi702125s)
    • (2008) Biochemistry , vol.47 , pp. 2211-2220
    • Qian, H.1    Cooper, J.A.2
  • 61
    • 33748107406 scopus 로고    scopus 로고
    • Phosphorylation energy hypothesis: Open chemical systems and their biological functions
    • doi:10.1146/annurev.physchem.58.032806.104550
    • Qian, H. 2007 Phosphorylation energy hypothesis: open chemical systems and their biological functions. Annu. Rev. Phys. Chem. 58, 113-142. (doi:10.1146/annurev.physchem.58.032806.104550)
    • (2007) Annu. Rev. Phys. Chem. , vol.58 , pp. 113-142
    • Qian, H.1
  • 62
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AKT
    • doi:10.1158/0008-5472.CAN-05-2925
    • O'Reilly, K. E. et al. 2006 mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AKT. Cancer Res. 66, 1500-1508. (doi:10.1158/0008-5472.CAN-05-2925)
    • (2006) Cancer Res. , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1
  • 63
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • doi:10.1038/nrm3025
    • Zoncu, R., Efeyan, A. & Sabatini, D. M. 2011 mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35. (doi:10.1038/nrm3025)
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 64
    • 77953209898 scopus 로고    scopus 로고
    • Q&A: Cancer: clues from cell metabolism
    • doi:10.1038/465562a
    • Kaelin, W. G. & Thompson, C. B. 2010 Q&A: cancer: clues from cell metabolism. Nature 465, 562-564. (doi:10.1038/465562a)
    • (2010) Nature , vol.465 , pp. 562-564
    • Kaelin, W.G.1    Thompson, C.B.2
  • 65
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • doi:10.1074/jbc.M200958200
    • Yu, C. et al. 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50 230-50 236. (doi:10.1074/jbc.M200958200)
    • (2002) J. Biol. Chem. , vol.277 , pp. 50230-50236
    • Yu, C.1
  • 66
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • doi:10.1038/nature05482
    • Kahn, S. E., Hull, R. L. & Utzschneider, K. M. 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846. (doi:10.1038/nature05482)
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.