Differentiation and quantification of endogenous and recombinant-methionyl human leptin in clinical plasma samples by immunocapture/mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 440-446

  Wang, Yan ^a   Heilig, Joseph S ^a  

^a AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

ELISA; Endogenous leptin; Immunocapture; LC MS MS; Obesity; Recombinant methionyl human leptin

Indexed keywords

LEPTIN; RECOMBINANT METHIONYL HUMAN LEPTIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; IMMUNOCHEMISTRY; INTERMETHOD COMPARISON; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

ANTI-OBESITY AGENTS; CALIBRATION; CHROMATOGRAPHY, REVERSE-PHASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LEPTIN; LIMIT OF DETECTION; LINEAR MODELS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84866241134     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.06.018     Document Type: Article

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