Total, free and bound leptin and thyroid function in elderly women with different body weights

Clinical Endocrinology

Volumn 68, Issue 6, 2008, Pages 1002-1008

  Ruscica, Massimiliano ^a   Dozio, Elena ^a   Gandini, Sara ^b   Gnocchi, Pierluigi ^c   Devalle, Guya Giuseppina ^c   Motta, Marcella ^a   Roti, Elio ^a   Magni, Paolo ^a,d  

^a UNIVERSITY OF MILAN   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^d Istituto di Endocrinologia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADIPOSE TISSUE; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; ENZYME ACTIVITY; FAST PROTEIN LIQUID CHROMATOGRAPHY; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SKINFOLD THICKNESS; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; UNDERWEIGHT;

EID: 43949088190     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.03133.x     Document Type: Article

References (49)

1. 1 Ahima, R.S. & Flier, J.S. (2000) Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism, 11, 327–332.
2. 2 Badman, M.K. & Flier, J.S. (2007) The adipocyte as an active participant in energy balance and metabolism. Gastroenterology, 132, 2103–2115.
3. 3 Sinha, M.K., Opentanova, I., Ohannesian, J.P., Kolaczwnski, J.W., Heiman, M.L., Hale, J., Becker, G.W., Bowsher, R.R., Stephens, T.W. & Caro, J.F. (1996) Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short‐term fasting. Journal of Clinical Investigation, 98, 1277–1282.
4. 4 Brabant, G., Horn, R., Von Zur Muhlen, A., Mayr, B., Wurster, U., Heidenreich, F., Schnabel, D., Gruters‐Kieslich, A., Zimmermann‐Belsing, T. & Feldt‐Rasmussen, U. (2000) Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia, 43, 438–442.
5. 5 Tank, J., Jordan, J., Diedrich, A., Schroeder, C., Furlan, R., Sharma, A.M., Luft, F.C. & Brabant, G. (2003) Bound leptin and sympathetic outflow in nonobese men. Journal of Clinical Endocrinology and Metabolism, 88, 4955–4959.
6. 6 Magni, P., Liuzzi, A., Ruscica, M., Dozio, E., Ferrario, S., Bussi, I., Minocci, A., Castagna, A., Motta, M. & Savia, G. (2005) Free and bound plasma leptin in normal weight and obese men and women: relationship with body composition, resting energy expenditure, insulin‐sensitivity, lipid profile and macronutrient preference. Clinical Endocrinology, 62, 189–196.
7. 7 Monteleone, P., Fabrazzo, M., Tortorella, A., Fuschino, A. & Maj, M. (2002) Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum. Molecular Psychiatry, 7, 641–646.
8. 8 Roberts, S.B. & Dallal, G.E. (2005) Energy requirements and aging. Public Health Nutrition, 8, 1028–1036.
9. 9 Morley, J.E. (2001) Anorexia, sarcopenia, and aging. Nutrition, 17, 660–663.
10. 10 Di Francesco, V., Fantin, F., Omizzolo, F., Residori, L., Bissoli, L., Bosello, O. & Zamboni, M. (2007) The anorexia of aging. Digestive Disease, 25, 129–137.
11. 11 Garry, P.J., Wayne, S.J. & Vellas, B. (2007) The New Mexico aging process study (1979–2003). A longitudinal study of nutrition, health and aging. Journal of Nutrition, Health and Aging, 11, 125–130.
12. 12 Chapman, I.M. (2004) Endocrinology of anorexia of ageing. Best Practice and Research. Clinical Endocrinology and Metabolism, 18, 437–452.
13. 13 Perry, H.M. 3rd, Morley, J.E., Horowitz, M., Kaiser, F.E., Miller, D.K. & Wittert, G. (1997) Body composition and age in African‐American and Caucasian women: relationship to plasma leptin levels. Metabolism, 46, 1399–1405.
14. 14 Smirnoff, P., Almiral‐Seliger, D. & Schwartz, B. (2001) Serum leptin levels in the elderly: relationship with gender and nutritional status. Journal of Nutrition, Health and Aging, 5, 29–32.
15. 15 Ruhl, C.E., Everhart, J.E., Ding, J., Goodpaster, B.H., Kanaya, A.M., Simonsick, E.M., Tylavsky, F.A. & Harris, T.B. (2004) Serum leptin concentrations and body adipose measures in older black and white adults. American Journal of Clinical Nutrition, 80, 576–583.
16. 16 Bertoli, S., Magni, P., Krogh, V., Ruscica, M., Dozio, E., Testolin, G. & Battezzati, A. (2006) Is ghrelin a signal of decreased fat‐free mass in elderly subjects? European Journal of Endocrinology, 155, 321–330.
17. 17 Ruhl, C.E., Harris, T.B., Ding, J., Goodpaster, B.H., Kanaya, A.M., Kritchevsky, S.B., Simonsick, E.M., Tylavsky, F.A. & Everhart, J.E. (2007) Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. American Journal of Clinical Nutrition, 85, 1121–1126.
18. 18 Moller, N., Brien, P.O. & Nair, S. (1998) Disruption of the relationship between fat content and leptin levels with aging in humans. Journal of Clinical Endocrinology and Metabolism, 83, 931–934.
19. 19 Isidori, A.M., Strollo, F., More, M., Caprio, M., Aversa, A., Moretti, C., Frajese, G., Riondino, G. & Fabbri, A. (2000) Leptin and aging: correlation with endocrine changes in male and female healthy adult population of different body weights. Journal of Clinical Endocrinology and Metabolism, 85, 1954–1962.
20. 20 Mariotti, S., Franceschi, C., Cossarizza, A. & Pinchera, A. (1995) The aging thyroid. Endocrine Reviews, 16, 686–707.
21. 21 Hollowell, J.G., Staehling, N.W., Flanders, W.D., Hannon, W.H., Gunter, E.W., Spencer, C.A. & Braverman, L.E. (2002) Serum TSH, T (4), and thyroid antibodies in the United States population (1988–94): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism, 87, 489–499.
22. 22 Papanicolaou, D.A. (2000) Euthyroid sick syndrome and the role of cytokines. Reviews in Endocrine and Metabolic Disorders, 1, 43–48.
23. 23 Roti, E., Minelli, R. & Salvi, M. (2000) Thyroid hormone metabolism in obesity. International Journal of Obesity, 24, S113–S115.
24. 24 Mariash, C.N. (2003) Thyroid hormone and the adipocyte. Journal of Clinical Endocrinology and Metabolism, 88, 5603–5604.
25. 25 Korbonits, M. (1998) Leptin and the thyroid–a puzzle with missing pieces. Clinical Endocrinology, 49, 569–572.
26. 26 Mantzoros, C.S., Ozata, M., Negrao, A.B., Suchard, M.A., Ziotopoulou, M., Caglayan, S., Elashoff, R.M., Cogswell, R.J., Negro, P., Liberty, V., Wong, M.L., Veldhuis, J., Ozdemir, I.C., Gold, P.W., Flier, J.S. & Licinio, J. (2001) Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin‐deficient subjects: evidence for possible partial TSH regulation by leptin in humans. Journal of Clinical Endocrinology and Metabolism, 86, 3284–3291.
27. 27 Magni, P., Ruscica, M., Dozio, E., Roti, E., Licastro, F., Motta, M. & Corsi, M.M. (2004) Free and bound leptin in prepubertal children with Down's syndrome and different degrees of adiposity. European Journal of Clinical Nutrition, 58, 1547–1549.
28. 28 Valcavi, R., Zini, M., Peino, R., Casanueva, F.F. & Dieguez, C. (1997) Influence of thyroid status on serum immunoreactive leptin levels. Journal of Clinical Endocrinology and Metabolism, 82, 1632–1634.
29. 29 Leonhardt, U., Ritzel, U., Schafre, G., Becker, W. & Ramadori, G. (1998) Serum leptin levels in hypo‐ and hyperthyroidism. Journal of Endocrinology, 157, 75–79.
30. 30 Corbetta, S., Englaro, P., Giambona, S., Persani, L., Blum, W.F. & Beck‐Peccoz, P. (1997) Lack of effects of circulating thyroid hormone levels on serum leptin concentrations. European Journal of Endocrinology, 137, 659–663.
31. 31 Iacobellis, G., Ribaudo, M.C., Zappaterreno, A., Iannucci, C.V. & Leonetti, F. (2005) Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical Endocrinology, 62, 487–491.
32. 32 Oge, A., Bayraktar, F., Saygili, F., Guney, E. & Demir, S. (2005) TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients. Endocrine Journal, 52, 213–217.
33. 33 Bastemir, M., Akin, F., Emral, R. & Alkis, E. (2007) Impact of insulin sensitivity in relationship with prolactin and thyroid stimulating hormone. Experimental and Clinical Endocrinology and Diabetes, 115, 257–260.
34. 34 Sergi, G., Coin, A., Enzi, G., Volpato, S., Inelmen, E.M., Buttarello, M., Peloso, M., Mulone, S., Marin, S. & Bonometto, P. (2006) Role of visceral proteins in detecting malnutrition in the elderly. European Journal of Clinical Nutrition, 60, 203–209.
35. 35 Pinkney, J.H., Goodrick, S., Katz, J., Johnson, A.B., Lightman, S.L., Coppack, S.W. & Mohamed‐Alì, V. (1998) Leptin and the pituitary–thyroid axis: a comparative study in lean, obese, hypothyroid and hyper thyroid subjects. Clinical Endocrinology, 49, 583–588.
36. 36 Nyrnes, A., Jorde, R. & Sundsfjord, J. (2006) Serum TSH is positively associated with BMI. International Journal of Obesity, 30, 100–105.
37. 37 De Pergola, G., Ciampolillo, A., Paolotti, S., Trerotoli, P. & Giorgino, R. (2007) Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clinical Endocrinology, 67, 265–269.
38. 38 Legradi, G., Emerson, C.H., Ahima, R.S., Fliers, J.S. & Lechan, R.M. (1997) Leptin prevents fasting‐induced suppression of prothyrotropin‐releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology, 138, 2569–2576.
39. 39 Lechan, R.M. & Fekete, C. (2006) The TRH neuron: a hypothalamic integrator of energy metabolism. Progress in Brain Research, 153, 209–235.
40. 40 Kim, M.S., Small, C.J., Stanley, S.A., Morgan, D.G., Seal, L.J., Kong, W.M., Edwards, C.M., Abusnana, S., Sunter, D., Ghatei, M.A. & Bloom, S.R. (2000) The central melanocortin system affects the hypothalamo–pituitary thyroid axis and may mediate the effect of leptin. Journal of Clinical Investigation, 105, 1005–1011.
41. 41 Kok, P., Roelfsema, F., Langendonk, J.G., Frolich, M., Burggraaf, J., Meinders, A.E. & Pijl, H. (2005) High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction. Journal of Clinical Endocrinology and Metabolism, 90, 4659–4663.
42. 42 Menendez, C., Baldelli, R., Camina, J.P., Escudero, B., Peino, R., Dieguez, C. & Casanueva, F.F. (2003) TSH stimulates leptin secretion by a direct effect on adipocytes. Journal of Endocrinology, 176, 7–12.
43. 43 Cabanelas, A., Lisboa, P.C., Moura, E.G. & Pazos‐Moura, C.C. (2006) Leptin acute modulation of the 5′‐deiodinase activities in hypothalamus, pituitary and brown adipose tissue of fed rats. Hormone and Metabolic Research, 38, 481–485.
44. 44 Andersen, S., Pedersen, K.M., Bruun, N.H. & Laurberg, P. (2002) Narrow individual variations in serum T (4) and T (3) in normal subjects: a clue to the understanding of subclinical thyroid disease. Journal of Clinical Endocrinology and Metabolism, 87, 1068–1072.
45. 45 Ortega, E., Pannacciulli, N., Bogardus, C. & Krakoff, J. (2007) Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. American Journal of Clinical Nutrition, 85, 440–445.
46. 46 Magni, P., Motta, M. & Martini, L. (2000) Leptin: a possible link between food intake, energy expenditure, and reproductive function. Regulatory Peptides, 92, 51–56.
47. 47 Neuhauser‐Berthold, M., Herbert, B.M., Luhrmann, P.M., Sultemeier, A.A., Blum, W.F., Frey, J. & Hebebrand, J. (2000) Resting metabolic rate, body composition, and serum leptin concentrations in a free‐living elderly population. European Journal of Endocrinology, 142, 486–492.
48. 48 Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S.B., Gallagher, D., Chu, F. & Leibel, R.L. (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. Journal of Clinical Endocrinology and Metabolism, 81, 3424–3427.
49. 49 Van Den Saffele, J.K., Goemaere, S., De Bacquer, D. & Kaufman, J.M. (1999) Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency? Clinical Endocrinology, 51, 81–88.