Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

Journal of Lipid Research

Volumn 53, Issue 10, 2012, Pages 2046-2056

  Arnedo, María ^a   Menao, Sebastián ^a   Puisac, Beatriz ^a   Teresa Rodrigo, María E ^a   Gil Rodríguez, María C ^a   López Viñas, Eduardo ^b,c   Gómez Puertas, Paulino ^b   Casals, Nuria ^d   Casale, César H ^e   Hegardt, Fausto G ^f   Pié, Juan ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^c Parque Científico de Madrid ^*  (Spain)

^d UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

^e DEPARTAMENTO DE QUÍMICA   (Argentina)

^f UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Brain; Endoplasmic reticulum cytosolic HMG CoA lyase; Enzymology; Ketone bodies; Kinetics; Liver; Lung; Lyase activity; Mitochondrial HMG CoA lyase

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COA LYASE LIKE 1; HYDROXYMETHYLGLUTARYL COENZYME A LYASE; ISOENZYME; LYASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; ENZYME ANALYSIS; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HMGCLL1 GENE; HUMAN; HUMAN TISSUE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; CYTOSOL; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; OXO-ACID-LYASES; PEROXISOMES; PROTEIN SPLICING;

EID: 84866172816     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M025700     Document Type: Article

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