Modeling of a mutation responsible for human 3-hydroxy-3- methylglutaryl-CoA lyase deficiency implicates histidine 233 as an active site residue

Journal of Biological Chemistry

Volumn 271, Issue 40, 1996, Pages 24604-24609

  Roberts, Jacqueline R ^a   Mitchell, Grant A ^b   Miziorko, Henry M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LYASE;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ESCHERICHIA COLI; PRIORITY JOURNAL; STOICHIOMETRY;

ACYL COENZYME A; BINDING SITES; DIETHYL PYROCARBONATE; ENZYME INHIBITORS; HISTIDINE; HUMANS; HYDROLYSIS; METABOLISM, INBORN ERRORS; OXO-ACID-LYASES; POINT MUTATION;

ESCHERICHIA COLI;

EID: 0029785209     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.40.24604     Document Type: Article

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