Activation of P2X7 receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Lee, Benjamin H ^a,c   Hwang, David M ^b,d   Palaniyar, Nades ^a,d   Grinstein, Sergio ^a,d   Philpott, Dana J ^d   Hu, Jim ^a,d  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PURINERGIC P2X7 RECEPTOR;

ACUTE DISEASE; ADENOVIRUS; ADENOVIRUS INFECTION; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL COMMUNICATION; COCULTURE; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; SIGNAL TRANSDUCTION; VIROLOGY;

ACUTE DISEASE; ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; CASPASE 1; CELL COMMUNICATION; COCULTURE TECHNIQUES; ENZYME INHIBITORS; EPITHELIAL CELLS; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84866172191     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035812     Document Type: Article

References (48)

1. Chen J, Subbarao K (2007) The Immunobiology of SARS*. Annu Rev Immunol 25: 443-472.
2. Maines TR, Szretter KJ, Perrone L, Belser JA, Bright RA, et al. (2008) Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response. Immunol Rev 225: 68-84.
3. Fukuyama S, Kawaoka Y (2011) The pathogenesis of influenza virus infections: the contributions of virus and host factors. Curr Opin Immunol 23: 481-486.
4. Rouse BT, Sehrawat S (2010) Immunity and immunopathology to viruses: what decides the outcome? Nat Rev Immunol 10: 514-526.
5. Cao H, Koehler DR, Hu J (2004) Adenoviral vectors for gene replacement therapy. Viral Immunol 17: 327-333.
6. Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, et al. (2003) Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 80: 148-158.
7. Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, et al. (2009) The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30: 556-565.
8. Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A (2009) Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 206: 79-87.
9. Thomas PG, Dash P, Aldridge JR, Jr., Ellebedy AH, Reynolds C, et al. (2009) The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30: 566-575.
10. Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, et al. (2008) The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452: 103-107.
11. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, et al. (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11: 395-402.
12. Pang IK, Iwasaki A (2011) Inflammasomes as mediators of immunity against influenza virus. Trends Immunol 32: 34-41.
13. Kanneganti TD (2010) Central roles of NLRs and inflammasomes in viral infection. Nat Rev Immunol 10: 688-698.
14. Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27: 229-265.
15. Di Virgilio F (2007) Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci 28: 465-472.
16. Bours MJ, Dagnelie PC, Giuliani AL, Wesselius A, Di Virgilio F (2011) P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. Front Biosci (Schol Ed) 3: 1443-1456.
17. Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, et al. (2009) Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A 106: 20388-20393.
18. Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, et al. (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15: 1170-1178.
19. Zsengeller Z, Otake K, Hossain SA, Berclaz PY, Trapnell BC (2000) Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection. J Virol 74: 9655-9667.
20. Muruve DA (2004) The innate immune response to adenovirus vectors. Hum Gene Ther 15: 1157-1166.
21. Kuzmin AI, Finegold MJ, Eisensmith RC (1997) Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo. Gene Ther 4: 309-316.
22. Lee BH, Kushwah R, Wu J, Ng P, Palaniyar N, et al. (2010) Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells. Immunol Lett 134: 93-102.
23. Zhang X, Mosser DM (2008) Macrophage activation by endogenous danger signals. J Pathol 214: 161-178.
24. Murgia M, Hanau S, Pizzo P, Rippa M, Di Virgilio F (1993) Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem 268: 8199-8203.
25. Beigi RD, Kertesy SB, Aquilina G, Dubyak GR (2003) Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol 140: 507-519.
26. Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, et al. (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176: 3877-3883.
27. Pfeiffer ZA, Guerra AN, Hill LM, Gavala ML, Prabhu U, et al. (2007) Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med 42: 1506-1516.
28. Pelegrin P, Barroso-Gutierrez C, Surprenant A (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180: 7147-7157.
29. Beyer EC, Steinberg TH (1991) Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J Biol Chem 266: 7971-7974.
30. McGaraughty S, Chu KL, Namovic MT, Donnelly-Roberts DL, Harris RR, et al. (2007) P2X7-related modulation of pathological nociception in rats. Neuroscience 146: 1817-1828.
31. Taylor SR, Turner CM, Elliott JI, McDaid J, Hewitt R, et al. (2009) P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol 20: 1275-1281.
32. Gasse P, Riteau N, Charron S, Girre S, Fick L, et al. (2009) Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 179: 903-913.
33. Wilhelm K, Ganesan J, Muller T, Durr C, Grimm M, et al. (2010) Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med 16: 1434-1438.
34. La Gruta NL, Kedzierska K, Stambas J, Doherty PC (2007) A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol 85: 85-92.
35. Rittirsch D, Flierl MA, Ward PA (2008) Harmful molecular mechanisms in sepsis. Nat Rev Immunol 8: 776-787.
36. Adriouch S, Dox C, Welge V, Seman M, Koch-Nolte F, et al. (2002) Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J Immunol 169: 4108-4112.
37. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 213-218.
38. Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, et al. (2010) Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 182: 774-783.
39. Muller T, Vieira RP, Grimm M, Durk T, Cicko S, et al. (2011) A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol 44: 456-464.
40. Weber FC, Esser PR, Muller T, Ganesan J, Pellegatti P, et al. (2010) Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med 207: 2609-2619.
41. Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, et al. (2007) Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 13: 913-919.
42. Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117: 3720-3732.
43. Schmitz N, Kurrer M, Bachmann MF, Kopf M (2005) Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79: 6441-6448.
44. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, et al. (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97: 587-600.
45. Teramoto S, Johnson LG, Huang W, Leigh MW, Boucher RC (1995) Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Hum Gene Ther 6: 1045-1053.
46. Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC (2006) Adenosine 59-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 112: 358-404.
47. Cicko S, Lucattelli M, Muller T, Lommatzsch M, De Cunto G, et al. (2010) Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema. J Immunol 185: 688-697.
48. Shayakhmetov DM, Lieber A (2000) Dependence of adenovirus infectivity on length of the fiber shaft domain. J Virol 74: 10274-10286.