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Volumn 47, Issue 15, 2008, Pages 4552-4564

Cell free expression and functional reconstitution of eukaryotic drug transporters

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; BIOCHEMISTRY; CRYSTAL STRUCTURE; DRUG PRODUCTS; TRANSPORT PROPERTIES;

EID: 42049096315     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800060w     Document Type: Article
Times cited : (55)

References (53)
  • 2
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • Rizwan, A. N., and Burckhardt, G. (2007) Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles. Pharm. Res. 24, 450-470.
    • (2007) Pharm. Res , vol.24 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 3
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • Koepsell, H., Lips, K., and Volk, C. (2007) Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications. Pharm. Res. 24, 1227-1251.
    • (2007) Pharm. Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 5
    • 0033515017 scopus 로고    scopus 로고
    • Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency
    • Wang, Y., Ye, J., Ganapathy, V., and Longo, N. (1999) Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Proc. Natl. Acad. Sci. U.S.A. 96, 2356-2360.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 2356-2360
    • Wang, Y.1    Ye, J.2    Ganapathy, V.3    Longo, N.4
  • 10
    • 38349193809 scopus 로고    scopus 로고
    • Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia
    • Wang, L., Giannoudis, A., Lane, S., Williamson, P., Pirmohamed, M., and Clark, R. E. (2008) Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin. Pharmacol. Ther. 83, 258-264.
    • (2008) Clin. Pharmacol. Ther , vol.83 , pp. 258-264
    • Wang, L.1    Giannoudis, A.2    Lane, S.3    Williamson, P.4    Pirmohamed, M.5    Clark, R.E.6
  • 11
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., and Koepsell, H. (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372, 549-552.
    • (1994) Nature , vol.372 , pp. 549-552
    • Gründemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 12
    • 0034703068 scopus 로고    scopus 로고
    • Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat
    • Budiman, T., Bamberg, E., Koepsell, H., and Nagel, G. (2000) Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat. J. Biol. Chem. 275, 29413-29420.
    • (2000) J. Biol. Chem , vol.275 , pp. 29413-29420
    • Budiman, T.1    Bamberg, E.2    Koepsell, H.3    Nagel, G.4
  • 13
    • 21644488840 scopus 로고    scopus 로고
    • Alkali cation binding and permeation in the rat organic cation transporter rOCT2
    • Schmitt, B. M., and Koepsell, H. (2005) Alkali cation binding and permeation in the rat organic cation transporter rOCT2. J. Biol. Chem. 280, 24481-24490.
    • (2005) J. Biol. Chem , vol.280 , pp. 24481-24490
    • Schmitt, B.M.1    Koepsell, H.2
  • 14
    • 0142179119 scopus 로고    scopus 로고
    • Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2
    • Volk, C., Gorboulev, V., Budiman, T., Nagel, G., and Koepsell, H. (2003) Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol. Pharmacol. 64, 1037-1047.
    • (2003) Mol. Pharmacol , vol.64 , pp. 1037-1047
    • Volk, C.1    Gorboulev, V.2    Budiman, T.3    Nagel, G.4    Koepsell, H.5
  • 15
    • 0034823731 scopus 로고    scopus 로고
    • Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter
    • Wolff, N. A., Grünwald, B., Friedrich, B., Lang, F., Godehardt, S., and Burckhardt, G. (2001) Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter. J. Am. Soc. Nephrol. 12, 2012-2018.
    • (2001) J. Am. Soc. Nephrol , vol.12 , pp. 2012-2018
    • Wolff, N.A.1    Grünwald, B.2    Friedrich, B.3    Lang, F.4    Godehardt, S.5    Burckhardt, G.6
  • 16
    • 0034617263 scopus 로고    scopus 로고
    • Abnormal sodium stimulation of carnitine transport in primary carnitine deficiency
    • Wang, Y., Meadows, T. A., and Longo, N. (2000) Abnormal sodium stimulation of carnitine transport in primary carnitine deficiency. J. Biol. Chem. 275, 20782-20786.
    • (2000) J. Biol. Chem , vol.275 , pp. 20782-20786
    • Wang, Y.1    Meadows, T.A.2    Longo, N.3
  • 17
    • 34250318936 scopus 로고    scopus 로고
    • The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid
    • Rizwan, A. N., Krick, W., and Burckhardt, G. (2007) The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. J. Biol. Chem. 282, 13402-13409.
    • (2007) J. Biol. Chem , vol.282 , pp. 13402-13409
    • Rizwan, A.N.1    Krick, W.2    Burckhardt, G.3
  • 18
    • 0041353145 scopus 로고    scopus 로고
    • Structure and mechanism of the lactose permease of Escherichia coli
    • Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science 301, 610-615.
    • (2003) Science , vol.301 , pp. 610-615
    • Abramson, J.1    Smirnova, I.2    Kasho, V.3    Verner, G.4    Kaback, H.R.5    Iwata, S.6
  • 19
    • 17644411713 scopus 로고    scopus 로고
    • Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease
    • Popp, C., Gorboulev, V., Müller, T. D., Gorbunov, D., Shatskaya, N., and Koepsell, H. (2005) Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol. Pharmacol. 67, 1600-1611.
    • (2005) Mol. Pharmacol , vol.67 , pp. 1600-1611
    • Popp, C.1    Gorboulev, V.2    Müller, T.D.3    Gorbunov, D.4    Shatskaya, N.5    Koepsell, H.6
  • 20
    • 27144555426 scopus 로고    scopus 로고
    • A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2)
    • Zhang, X., Shirahatti, N. V., Mahadevan, D., and Wright, S. H. (2005) A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). J. Biol. Chem. 280, 34813-34822.
    • (2005) J. Biol. Chem , vol.280 , pp. 34813-34822
    • Zhang, X.1    Shirahatti, N.V.2    Mahadevan, D.3    Wright, S.H.4
  • 21
    • 34548645392 scopus 로고    scopus 로고
    • Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity
    • Sturm, A., Gorboulev, V., Gorbunov, D., Keller, T., Volk, C., Schmitt, B. M., Schlachtbauer, P., Ciarimboli, G., and Koepsell, H. (2007) Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Am. J. Physiol. 293, F767-F779.
    • (2007) Am. J. Physiol , vol.293
    • Sturm, A.1    Gorboulev, V.2    Gorbunov, D.3    Keller, T.4    Volk, C.5    Schmitt, B.M.6    Schlachtbauer, P.7    Ciarimboli, G.8    Koepsell, H.9
  • 22
    • 37349126109 scopus 로고    scopus 로고
    • High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices
    • Gorbunov, D., Gorboulev, V., Shatskaya, N., Mueller, T., Bamberg, E., Friedrich, T., and Koepsell, H. (2008) High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices. Mol. Pharmacol. 73, 50-61.
    • (2008) Mol. Pharmacol , vol.73 , pp. 50-61
    • Gorbunov, D.1    Gorboulev, V.2    Shatskaya, N.3    Mueller, T.4    Bamberg, E.5    Friedrich, T.6    Koepsell, H.7
  • 23
    • 24644492295 scopus 로고    scopus 로고
    • Purification and functional reconstitution of the rat organic cation transporter OCT1
    • Keller, T., Elfeber, M., Gorboulev, V., Reiländer, H., and Koepsell, H. (2005) Purification and functional reconstitution of the rat organic cation transporter OCT1. Biochemistry 44, 12253-12263.
    • (2005) Biochemistry , vol.44 , pp. 12253-12263
    • Keller, T.1    Elfeber, M.2    Gorboulev, V.3    Reiländer, H.4    Koepsell, H.5
  • 24
    • 0030590117 scopus 로고    scopus 로고
    • cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
    • Okuda, M., Saito, H., Urakami, Y., Takano, M., and Inui, K. (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun. 224, 500-507.
    • (1996) Biochem. Biophys. Res. Commun , vol.224 , pp. 500-507
    • Okuda, M.1    Saito, H.2    Urakami, Y.3    Takano, M.4    Inui, K.5
  • 25
    • 0030781076 scopus 로고    scopus 로고
    • Expression cloning and characterization of rOAT1, the basolateral organic anion transporter in rat kidney
    • Sweet, D. H., Wolff, N. A., and Pritchard, J. B. (1997) Expression cloning and characterization of rOAT1, the basolateral organic anion transporter in rat kidney. J. Biol. Chem. 272, 30088-30095.
    • (1997) J. Biol. Chem , vol.272 , pp. 30088-30095
    • Sweet, D.H.1    Wolff, N.A.2    Pritchard, J.B.3
  • 26
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., and Endou, H. (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272, 18526-18529.
    • (1997) J. Biol. Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 28
    • 0030874298 scopus 로고    scopus 로고
    • Comparison of NH exchange and circular dichroism as techniques for measuring the parameters of the helix-coil transition in peptides
    • Rohl, C. A., and Baldwin, R. L. (1997) Comparison of NH exchange and circular dichroism as techniques for measuring the parameters of the helix-coil transition in peptides. Biochemistry 36, 8435-8442.
    • (1997) Biochemistry , vol.36 , pp. 8435-8442
    • Rohl, C.A.1    Baldwin, R.L.2
  • 29
    • 0029889988 scopus 로고    scopus 로고
    • PHD: Predicting one-dimensional protein structure by profile-based neural networks
    • Rost, B. (1996) PHD: Predicting one-dimensional protein structure by profile-based neural networks. Methods Enzymol. 266, 525-539.
    • (1996) Methods Enzymol. 266 , pp. 525-539
    • Rost, B.1
  • 30
    • 0025683364 scopus 로고
    • Reconstitution and fractionation of renal brush border transport proteins
    • Koepsell, H., and Seibicke, S. (1990) Reconstitution and fractionation of renal brush border transport proteins. Methods Enzymol. 191, 583-605.
    • (1990) Methods Enzymol , vol.191 , pp. 583-605
    • Koepsell, H.1    Seibicke, S.2
  • 32
    • 0035976973 scopus 로고    scopus 로고
    • The plasma membrane-associated protein RS1 decreases transcription of the transporter SGLT1 in confluent LLC-PK1 cells
    • Korn, T., Kühlkamp, T., Track, C., Schatz, I., Baumgarten, K., Gorboulev, V., and Koepsell, H. (2001) The plasma membrane-associated protein RS1 decreases transcription of the transporter SGLT1 in confluent LLC-PK1 cells. J. Biol. Chem. 276, 45330-45340.
    • (2001) J. Biol. Chem , vol.276 , pp. 45330-45340
    • Korn, T.1    Kühlkamp, T.2    Track, C.3    Schatz, I.4    Baumgarten, K.5    Gorboulev, V.6    Koepsell, H.7
  • 33
    • 0033574034 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
    • Race, J. E., Grassl, S. M., Williams, W. J., and Holtzman, E. J. (1999) Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem. Biophys. Res. Commun. 255, 508-514.
    • (1999) Biochem. Biophys. Res. Commun , vol.255 , pp. 508-514
    • Race, J.E.1    Grassl, S.M.2    Williams, W.J.3    Holtzman, E.J.4
  • 34
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • Hosoyamada, M., Sekine, T., Kanai, Y., and Endou, H. (1999) Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. 276, F122-F128.
    • (1999) Am. J. Physiol , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 35
    • 34548022843 scopus 로고    scopus 로고
    • Cl-Dependent up-regulation of human organic anion transporters: Different effects on transport kinetics between hOAT1 and hOAT3
    • Ueo, H., Motohashi, H., Katsura, T., and Inui, K.-i. (2007) Cl-Dependent up-regulation of human organic anion transporters: Different effects on transport kinetics between hOAT1 and hOAT3. Am. J. Physiol. 293, F391-F397.
    • (2007) Am. J. Physiol , vol.293
    • Ueo, H.1    Motohashi, H.2    Katsura, T.3    Inui, K.-I.4
  • 37
    • 1242319564 scopus 로고    scopus 로고
    • In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state
    • Elbaz, Y., Steiner-Mordoch, S., Danieli, T., and Schuldiner, S. (2004) In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state. Proc. Natl. Acad. Sci. U.S.A. 101, 1519-1524.
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 1519-1524
    • Elbaz, Y.1    Steiner-Mordoch, S.2    Danieli, T.3    Schuldiner, S.4
  • 38
    • 4744351698 scopus 로고    scopus 로고
    • Cell-free synthesis of a functional ion channel in the absence of a membrane and in the presence of detergent
    • Berrier, C., Park, K.-H., Abes, S., Bibonne, A., Betton, J.-M., and Ghazi, A. (2004) Cell-free synthesis of a functional ion channel in the absence of a membrane and in the presence of detergent. Biochemistry 43, 12585-12591.
    • (2004) Biochemistry , vol.43 , pp. 12585-12591
    • Berrier, C.1    Park, K.-H.2    Abes, S.3    Bibonne, A.4    Betton, J.-M.5    Ghazi, A.6
  • 39
    • 28244458078 scopus 로고    scopus 로고
    • Evaluation of detergents for the soluble expression of α-helical and β-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system
    • Klammt, C., Schwarz, D., Fendler, K., Haase, W., Dötsch, V., and Bernhard, F. (2005) Evaluation of detergents for the soluble expression of α-helical and β-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system. FEBS J. 272, 6024-6038.
    • (2005) FEBS J , vol.272 , pp. 6024-6038
    • Klammt, C.1    Schwarz, D.2    Fendler, K.3    Haase, W.4    Dötsch, V.5    Bernhard, F.6
  • 40
    • 15744391469 scopus 로고    scopus 로고
    • Expression of G protein coupled receptors in a cell-free translational system using detergents and thioredoxin-fusion vectors
    • Ishihara, G., Goto, M., Saeki, M., Ito, K., Hori, T., Kigawa, T., Shirouzu, M., and Yokoyama, S. (2005) Expression of G protein coupled receptors in a cell-free translational system using detergents and thioredoxin-fusion vectors. Protein Expression Purif. 41, 27-37.
    • (2005) Protein Expression Purif , vol.41 , pp. 27-37
    • Ishihara, G.1    Goto, M.2    Saeki, M.3    Ito, K.4    Hori, T.5    Kigawa, T.6    Shirouzu, M.7    Yokoyama, S.8
  • 42
    • 34447630299 scopus 로고    scopus 로고
    • Functional cell-free synthesis of a seven helix membrane protein: In situ insertion of bacteriorhodopsin into liposomes
    • Kalmbach, R., Chizhov, I., Schumacher, M. C., Friedrich, T., Bamberg, E., and Engelhard, M. (2007) Functional cell-free synthesis of a seven helix membrane protein: In situ insertion of bacteriorhodopsin into liposomes. J. Mol. Biol. 371, 639-648.
    • (2007) J. Mol. Biol , vol.371 , pp. 639-648
    • Kalmbach, R.1    Chizhov, I.2    Schumacher, M.C.3    Friedrich, T.4    Bamberg, E.5    Engelhard, M.6
  • 43
    • 33947171595 scopus 로고    scopus 로고
    • Preparative scale cell-free expression systems: New tools for the large scale preparation of integral membrane proteins for functional and structural studies
    • Schwarz, D., Klammt, C., Koglin, A., Löhr, F., Schneider, B., Dötsch, V., and Bernhard, F. (2007) Preparative scale cell-free expression systems: New tools for the large scale preparation of integral membrane proteins for functional and structural studies. Methods 41, 355-369.
    • (2007) Methods , vol.41 , pp. 355-369
    • Schwarz, D.1    Klammt, C.2    Koglin, A.3    Löhr, F.4    Schneider, B.5    Dötsch, V.6    Bernhard, F.7
  • 44
    • 0028224356 scopus 로고
    • A large-conductance mechanosensitive channel in E. coli encoded by mscL alone
    • Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R., and Kung, C. (1994) A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature 368, 265-268.
    • (1994) Nature , vol.368 , pp. 265-268
    • Sukharev, S.I.1    Blount, P.2    Martinac, B.3    Blattner, F.R.4    Kung, C.5
  • 46
    • 0021230113 scopus 로고
    • + cotransport systems from renal brush-border membranes. Properties of the L-glutamate transporter in proteoliposomes
    • + cotransport systems from renal brush-border membranes. Properties of the L-glutamate transporter in proteoliposomes. J. Biol. Chem. 259, 6548-6558.
    • (1984) J. Biol. Chem , vol.259 , pp. 6548-6558
    • Koepsell, H.1    Korn, K.2    Ferguson, D.3    Menuhr, H.4    Ollig, D.5    Haase, W.6
  • 47
    • 0020530660 scopus 로고
    • +/D-glucose cotransport from kidney brush-border membranes
    • +/D-glucose cotransport from kidney brush-border membranes. Biochim. Biophys. Acta 730, 119-129.
    • (1983) Biochim. Biophys. Acta , vol.730 , pp. 119-129
    • Ducis, I.1    Koepsell, H.2
  • 48
    • 0023514358 scopus 로고
    • + of p-aminohippurate uptake into rat renal basolateral membrane vesicles
    • + of p-aminohippurate uptake into rat renal basolateral membrane vesicles. Am. J. Physiol. 253, F795-F801.
    • (1987) Am. J. Physiol , vol.253
    • Shimada, H.1    Moewes, B.2    Burckhardt, G.3
  • 49
    • 0023765854 scopus 로고
    • Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles
    • Pritchard, J. B. (1988) Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles. Am. J. Physiol. 255, F597-F604.
    • (1988) Am. J. Physiol , vol.255
    • Pritchard, J.B.1
  • 50
    • 0141813480 scopus 로고    scopus 로고
    • Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells
    • Aslamkhan, A., Han, Y.-H., Walden, R., Sweet, D. H., and Pritchard, J. B. (2003) Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells. Am. J. Physiol. 285, F775-F783.
    • (2003) Am. J. Physiol , vol.285
    • Aslamkhan, A.1    Han, Y.-H.2    Walden, R.3    Sweet, D.H.4    Pritchard, J.B.5
  • 51
    • 0027255998 scopus 로고
    • p-Aminohippurate/2-oxoglutarate exchange in bovine renal brush-border and basolateral membrane vesicles
    • Schmitt, C., and Burckhardt, G. (1993) p-Aminohippurate/2-oxoglutarate exchange in bovine renal brush-border and basolateral membrane vesicles. Pfluegers Arch. 423, 280-290.
    • (1993) Pfluegers Arch , vol.423 , pp. 280-290
    • Schmitt, C.1    Burckhardt, G.2
  • 52
    • 0022518151 scopus 로고
    • Role of chloride on carrier-mediated transport of p-aminohippurate in rat renal basolateral membrane vesicles
    • Inui, K., Takano, M., Okano, T., and Hori, R. (1986) Role of chloride on carrier-mediated transport of p-aminohippurate in rat renal basolateral membrane vesicles. Biochim. Biophys. Acta 855, 425-428.
    • (1986) Biochim. Biophys. Acta , vol.855 , pp. 425-428
    • Inui, K.1    Takano, M.2    Okano, T.3    Hori, R.4
  • 53
    • 0027491701 scopus 로고
    • Modulation by anions of p-aminohippurate transport in bovine renal basolateral membrane vesicles
    • Schmitt, C., and Burckhardt, G. (1993) Modulation by anions of p-aminohippurate transport in bovine renal basolateral membrane vesicles. Pfluegers Arch. 425, 241-247.
    • (1993) Pfluegers Arch , vol.425 , pp. 241-247
    • Schmitt, C.1    Burckhardt, G.2


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