Hippo signalling controls Dronc activity to regulate organ size in Drosophila

Cell Death and Differentiation

Volumn 19, Issue 10, 2012, Pages 1664-1676

  Verghese, S ^a   Bedi, S ^a   Kango Singh, M ^a  

^a UNIVERSITY OF DAYTON   (United States)

Author keywords

caspases; dronc; Drosophila; Hippo pathway; imaginal discs; organ size

Indexed keywords

DRONC PROTEIN; DROSOPHILA PROTEIN; HIPPO PROTEIN; UNCLASSIFIED DRUG; YKI PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DROSOPHILA; IMAGINAL DISC; NONHUMAN; ORGAN SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; DROSOPHILA; DROSOPHILA PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; ORGAN SIZE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 84866116123     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.48     Document Type: Article

References (40)

1. Halder G, Johnson RL. Hippo signaling: growth control and beyond. Development 2011; 138: 9-22.
2. Kango-Singh M, Singh A. Regulation of organ size: insights from the Drosophila Hippo signaling pathway. Dev Dyn 2009; 238: 1627-1637.
3. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 2003; 5: 921-927. (Pubitemid 37220699)
4. Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, Hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003; 114: 457-467. (Pubitemid 37100994)
5. Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 2003; 17: 2514-2519. (Pubitemid 37271421)
6. Wu S, Huang J, Dong J, Pan D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 2003; 114: 445-456. (Pubitemid 37100993)
7. Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 2003; 5: 914-920. (Pubitemid 37220698)
8. Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 1995; 121: 1053-1063.
9. Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 1995; 9: 534-546.
10. Tapon N, Harvey K, Bell D, Wahrer D, Schiripo T, Haber D et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002; 110: 467.
11. Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 2002; 129: 5719-5730. (Pubitemid 36054615)
12. Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005; 120: 675-685. (Pubitemid 40343079)
13. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 2005; 122: 421-434. (Pubitemid 41127143)
14. Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 2006; 8: 27-36. (Pubitemid 43064794)
15. Baumgartner R, Poernbacher I, Buser N, Hafen E, Stocker H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell 2010; 18: 309-316.
16. Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 2010; 18: 300-308.
17. Yu J, Zheng Y, Dong J, Klusza S, Deng WM, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 2010; 18: 288-299.
18. Chen CL, Gajewski KM, Hamaratoglu F, Bossuyt W, Sansores-Garcia L, Tao C et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci USA 2010; 107: 15810-15815.
19. Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE. Lgl, a PKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010; 20: 573-581.
20. Robinson BS, Huang J, Hong Y, Moberg KH. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol 2010; 20: 582-590.
21. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD. Delineation of a Fat tumor suppressor pathway. Nat Genet 2006; 38: 1142-1150. (Pubitemid 44470359)
22. Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C et al. The fat cadherin acts through the Hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 2006; 16: 2090-2100. (Pubitemid 44692095)
23. Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol 2006; 16: 2101-2110. (Pubitemid 44692100)
24. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the Hippo signaling pathway. Curr Biol 2006; 16: 2081-2089. (Pubitemid 44692094)
25. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA et al. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002; 110: 467-478. (Pubitemid 35232290)
26. Quinn LM, Dorstyn L, Mills K, Colussi PA, Chen P, Coombe M et al. An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J Biol Chem 2000; 275: 40416-40424. (Pubitemid 32065756)
27. Meier P, Silke J, Leevers SJ, Evan GI. The Drosophila caspase DRONC is regulated by DIAP1. EMBO J 2000; 19: 598-611. (Pubitemid 30093733)
28. Orme M, Meier P. Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death. Apoptosis 2009; 14: 950-960.
29. Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol 1999; 1: 272-279. (Pubitemid 129495777)
30. Hawkins CJ, Yoo SJ, Peterson EP, Wang SL, Vernooy SY, Hay BA. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J Biol Chem 2000; 275: 27084-27093.
31. Muro I, Monser K, Clem RJ. Mechanism of Dronc activation in Drosophila cells. J Cell Sci 2004; 117(Pt 21): 5035-5041. (Pubitemid 39517519)
32. Shapiro PJ, Hsu HH, Jung H, Robbins ES, Ryoo HD. Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol 2008; 10: 1440-1446.
33. Fan Y, Bergmann A. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Cell Death Differ 2010; 17: 534-539.
34. Xu D, Li Y, Arcaro M, Lackey M, Bergmann A. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 2005; 132: 2125-2134. (Pubitemid 40744472)
35. Daish TJ, Cakouros D, Kumar S. Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Cell Death Differ 2003; 10: 1348-1356. (Pubitemid 37536739)
36. Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev 2005; 122: 914-927. (Pubitemid 40961552)
37. Daish TJ, Mills K, Kumar S. Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell 2004; 7: 909-915. (Pubitemid 39654734)
38. Chew SK, Akdemir F, Chen P, Lu WJ, Mills K, Daish T et al. The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell 2004; 7: 897-907. (Pubitemid 39654733)
39. Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S. The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol 2006; 172: 809-815.
40. Bertini E, Oka T, Sudol M, Strano S, Blandino G. YAP: at the crossroad between transformation and tumor suppression. Cell Cycle, 2009; 8: 49-57.