Application of DBS sampling in combination with LC-MS/MS for pharmacokinetic evaluation of a compound with species-specific blood-to-plasma partitioning

Bioanalysis

Volumn 4, Issue 16, 2012, Pages 2037-2047

  Xu, Guifen ^a   Chen, Jiyun S ^a   Phadnis, Ruta ^a   Huang, Tom ^a   Uyeda, Craig ^a   Soto, Marcus ^a   Stouch, Brian ^a   Wells, Mary C ^a   James, Christopher A ^a   Carlson, Timothy J ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DRIED BLOOD SPOT TESTING; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SPECIES DIFFERENCE; TANDEM MASS SPECTROMETRY;

ANIMALS; BLOOD PROTEINS; BLOOD SPECIMEN COLLECTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRIED BLOOD SPOT TESTING; INJECTIONS, INTRAVENOUS; MALE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PLASMA; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84866104329     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.167     Document Type: Article

References (12)

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