Use of dried blood spots in drug development: Pharmacokinetic considerations

AAPS Journal

Volumn 12, Issue 3, 2010, Pages 290-293

  Rowland, Malcolm ^a   Emmons, Gary T ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b SANOFI   (France)

Author keywords

dried blood spots; drug development; pharmacokinetics

Indexed keywords

ACETAZOLAMIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CAFFEINE; CHLORTALIDONE; CYCLOSPORIN; SULFONAMIDE; TACROLIMUS;

AREA UNDER THE CURVE; BLOOD ANALYSIS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXPOSURE; DRUG MONITORING; DRUG RESEARCH; HEMATOCRIT; HUMAN; MICRODIALYSIS; NONHUMAN; NOTE; SPECIES DIFFERENCE; BLOOD; DRUG DESIGN; PHARMACOKINETICS;

BLOOD; DRUG DESIGN; HUMANS; PHARMACOKINETICS;

EID: 77955946360     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9188-y     Document Type: Note

References (27)

1. R ter Heine H Rosing ECM van Gorp JW Mulder JH Beijnen ADR Huitema 2009 Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry J Pharm Biomed Anal 49 393 400 10.1016/j.jpba.2008.10.040 19059744
2. M Barfield N Spooner R Lad S Parry S Fowles 2008 Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies J Chromatograph B 870 32 7 10.1016/j.jchromb.2008.05.025 1:CAS:528:DC%2BD1cXotlOjsb8%3D
3. W Li FLS Tse 2010 Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules Biomed Chromatog 24 49 65 10.1002/bmc.1367 1:CAS:528:DC%2BD1MXhsF2jtrfN
4. J van der Heijden Y de Beer K Hoogtanders M Christiaans GJ de Jong C Neef, et al. 2009 Therapeutic drug monitoring of everolimus using the dried blood spot methd in combination with liquid chromatography-mass spectrometry J Pharm Biomed Anal 50 664 70 10.1016/j.jpba.2008.11.021 19155152
5. X Liang Y Li M Barfield QC Ji 2009 Study of dried blood spots techniques for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS J Chromatograph B 877 799 806 10.1016/j.jchromb. 2009.02.015 1:CAS:528:DC%2BD1MXivVentrY%3D
6. R Guthrue A Suzi 1963 A simple phenylalanine method for detecting phenylketouria in large populations of newborn infants Pediatrics 23 338 43
7. N Spooner R Lad M Barfield 2009 Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method Anal Chem 81 1557 63 10.1021/ac8022839 1:CAS:528:DC%2BD1MXns1Ogsg%3D%3D 19154107
8. P Beaudette KP Bateman 2004 Discovery stage pharmacokinetics using dried blood spots J Chromatograph B 809 153 8 10.1016/j.jchromb.2004.06.018 1:CAS:528:DC%2BD2cXmt1Ohs7o%3D
9. PM Edelbroeck J van der Heijden LML Stolk 2009 Dried blood spot methods in therapeutic drug monitoring: methods, assays and pitfalls Ther Drug Monit 31 327 36 10.1097/FTD.0b013e31819e91ce
10. M Holub K Tuschl R Ratschmann KA Strnadová A Muhl G Heinze, et al. 2006 Influence of hematocrit and localization of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry Clin Chim Acta 373 27 31 10.1016/j.cca.2006.04.013 1:CAS:528: DC%2BD28XptFSqs7s%3D 16797519
11. JV Mei JR Alexander BW Adam WH Hannon 2001 Use of filter paper for the collection and analysis of human whole blood specimens J Nutrition 131 1631S 6 1:STN:280:DC%2BD3Mzis1eiug%3D%3D
12. CWN Damen H Rosing JHM Schellens JH Biejnen 2009 Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D Anal Bioanal Chem 394 1171 82 10.1007/s00216-009-2775-z 1:CAS:528:DC%2BD1MXkvFGjt7g%3D 19387621
13. TW McDade S Williams JJ Snodgrass 2007 What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research Demography 44 899 925 10.1353/dem.2007.0038 18232218
14. J Déglon A Thomas A Cataldo P Mangin C Staub 2009 On-line desorption of dried blood spot: a novel approach for the direct LC/MS analysis of μ-whole blood samples J Pharm Biomed Anal 49 1034 9 10.1016/j.jpba.2009. 02.001 19269771
15. Rowland M, Tozer TN. Clinical pharmacokinetics: concepts and applications. 4th ed. Baltimore: Lippincott, Williams & Wilkins; 2010. p. 157-68.
16. M Rowland 1972 Influence of route of administration on drug availability J Pharm Sci 61 70 4 10.1002/jps.2600610111 1:CAS:528:DyaE38XkvFyktg%3D%3D 5019220
17. T Rodgers M Rowland 2007 Mechanistic approaches to volume of distribution predictions: understanding the processes Pharm Res 24 918 33 10.1007/s11095-006-9210-3 1:CAS:528:DC%2BD2sXkslWgt7c%3D 17372687
18. Tozer TN. Implications of altered plasma protein binding in disease states. In: Benet LZ, Massoud N, Gambertoglio JG, editors. Pharmacokinetic basis of drug treatment. New York: Raven Press; 1983. p. 173-93.
19. T Rodgers D Leahy M Rowland 2005 Physiologically-based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases J Pharm Sci 94 1259 76 10.1002/jps.20322 1:CAS:528:DC%2BD2MXkvF2qtLs%3D 15858854
20. R Kawai D Matthew C Tanaka M Rowland 1998 Physiologically-based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human J Pharmacol Expt Therap 287 457 68 1:CAS:528:DyaK1cXnsVertr0%3D
21. W Piekoszewski J Jusko 1992 Plasma protein binding of tacrolimus in humans J Pharm Sci 82 340 1 10.1002/jps.2600820325
22. SH Akbas S Ozdem S Caglar M Tuncer A Gurkan L Yucetin, et al. 2005 Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods Clin Biochem 38 552 7 10.1016/j.clinbiochem.2005.02.011 1:CAS:528:DC%2BD2MXktVOgu74%3D 15885236
23. K Hoogtanders J van der Heijden M Christiaans P Edelbroeck JP van Hoof LML Stolk 2007 Therapeutic drug monitoring of tacrolimus with the dried blood spot method J Pharm Biomed Anal 44 658 64 10.1016/j.jpba.2006.11.023 1:CAS:528:DC%2BD2sXnslWhsbg%3D 17184953
24. AV Mee PY Wong C Sun L Oei S Elliott N Naik, et al. 1991 Monitoring of cyclosporine concentrations by using dry blood-spot samples J Clin Lab Analysis 5 74 7 10.1002/jcla.1860050114 1:CAS:528:DyaK3MXktVSisr8%3D
25. R Kawai M Lemaire J-L Steimer A Bruelisauer W Niederberger M Rowland 1994 Physiologically-based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125 J Pharmacokin Pharmacodyn 22 327 65 1:CAS:528:DyaK2MXls1Cnsrk%3D
26. HLJ Fleuren M van Rossum 1977 Nonlinear relationship between plasma and red blood cell pharmacokinetics of chlorthalidone in man J Pharmacokin Pharmacodyn 5 359 75 1:CAS:528:DyaE1cXhsFOjsw%3D%3D
27. B Legg M Rowland 1988 Saturable binding of cyclosporin A to erythrocytes: estimation of binding parameters in renal transplant patients and implications for bioavailability assessment Pharm Res 5 80 5 10.1023/A:1015932032609 1:CAS:528:DyaL1cXhs1Sru7g%3D 3073383