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Volumn 10, Issue 1, 2012, Pages

Development of a new humanized mouse model to study acute inflammatory arthritis

Author keywords

Etanercept; Humanized mouse; Leukocytes; Rheumatoid arthritis

Indexed keywords

ANTIBODY; CD34 ANTIGEN; CD45 ANTIGEN; ETANERCEPT; FREUND ADJUVANT; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PHOSPHATE BUFFERED SALINE; THIOGLYCOLIC ACID;

EID: 84866096104     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-190     Document Type: Article
Times cited : (28)

References (44)
  • 1
    • 33847783057 scopus 로고    scopus 로고
    • Macrophage biology and immunology: man is not a mouse
    • discussion 580
    • Schneemann M, Schoeden G. Macrophage biology and immunology: man is not a mouse. J Leukoc Biol 2007, 81:579. discussion 580.
    • (2007) J Leukoc Biol , vol.81 , pp. 579
    • Schneemann, M.1    Schoeden, G.2
  • 2
    • 54349089048 scopus 로고    scopus 로고
    • Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
    • Hegen M, Keith JCJ, Collins M, Nickerson-Nutter CL. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Annals Rheum Dis 2008, 67:1505-1515.
    • (2008) Annals Rheum Dis , vol.67 , pp. 1505-1515
    • Hegen, M.1    Keith, J.C.J.2    Collins, M.3    Nickerson-Nutter, C.L.4
  • 4
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • 10.1038/nri2017, 17259968
    • Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007, 7:118-130. 10.1038/nri2017, 17259968.
    • (2007) Nat Rev Immunol , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 5
    • 33646836119 scopus 로고    scopus 로고
    • Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis
    • Moritz F, Distler O, Ospelt C, Gay RE, Gay S. Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis. Nature Clin Prac Rheum 2006, 2:153-162.
    • (2006) Nature Clin Prac Rheum , vol.2 , pp. 153-162
    • Moritz, F.1    Distler, O.2    Ospelt, C.3    Gay, R.E.4    Gay, S.5
  • 6
    • 77949739003 scopus 로고    scopus 로고
    • Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint
    • 10.3899/jrheum.090317, 20110518
    • Chang NH, Inman RD, Dick JE, Wither JE. Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint. J Rheumatol 2010, 37:496-502. 10.3899/jrheum.090317, 20110518.
    • (2010) J Rheumatol , vol.37 , pp. 496-502
    • Chang, N.H.1    Inman, R.D.2    Dick, J.E.3    Wither, J.E.4
  • 7
    • 84863981921 scopus 로고    scopus 로고
    • Macrophages from nonobese diabetic mouse have a selective defect in IFN-gamma but not IFN-alpha/beta receptor pathway
    • 10.1007/s10875-012-9682-3, 22396045
    • Lee MS, Kwon HJ, Kim HS. Macrophages from nonobese diabetic mouse have a selective defect in IFN-gamma but not IFN-alpha/beta receptor pathway. J Clin Immunol 2012, 32:753-761. 10.1007/s10875-012-9682-3, 22396045.
    • (2012) J Clin Immunol , vol.32 , pp. 753-761
    • Lee, M.S.1    Kwon, H.J.2    Kim, H.S.3
  • 8
    • 79953773519 scopus 로고    scopus 로고
    • Opportunistic bacterial infections in breeding colonies of the NSG mouse strain
    • Foreman O, Kavirayani AM, Griffey SM, Reader R, Shultz LD. Opportunistic bacterial infections in breeding colonies of the NSG mouse strain. Vet Path 2011, 48:495-499.
    • (2011) Vet Path , vol.48 , pp. 495-499
    • Foreman, O.1    Kavirayani, A.M.2    Griffey, S.M.3    Reader, R.4    Shultz, L.D.5
  • 9
    • 70349918640 scopus 로고    scopus 로고
    • The utilization of humanized mouse models for the study of human retroviral infections
    • 10.1186/1742-4690-6-76, 2743631, 19674458
    • Van Duyne R, Pedati C, Guendel I, Carpio L, Kehn-Hall K, Saifuddin M, Kashanchi F. The utilization of humanized mouse models for the study of human retroviral infections. Retrovirology 2009, 6:76. 10.1186/1742-4690-6-76, 2743631, 19674458.
    • (2009) Retrovirology , vol.6 , pp. 76
    • Van Duyne, R.1    Pedati, C.2    Guendel, I.3    Carpio, L.4    Kehn-Hall, K.5    Saifuddin, M.6    Kashanchi, F.7
  • 10
    • 69449084286 scopus 로고    scopus 로고
    • Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice
    • 10.1189/jlb.1008615, 2726769, 19369639
    • Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol 2009, 86:219-227. 10.1189/jlb.1008615, 2726769, 19369639.
    • (2009) J Leukoc Biol , vol.86 , pp. 219-227
    • Unsinger, J.1    McDonough, J.S.2    Shultz, L.D.3    Ferguson, T.A.4    Hotchkiss, R.S.5
  • 11
    • 57549093082 scopus 로고    scopus 로고
    • Creation of "humanized" mice to study human immunity
    • Chapter 15:Unit 15 21.
    • Pearson T, Greiner DL, Shultz LD. Creation of "humanized" mice to study human immunity. Curr Protoc Immunol 2008, Chapter 15:Unit 15 21..
    • (2008) Curr Protoc Immunol
    • Pearson, T.1    Greiner, D.L.2    Shultz, L.D.3
  • 14
    • 33750302629 scopus 로고    scopus 로고
    • Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis
    • 10.1002/art.22133, 17009248
    • Scatizzi JC, Bickel E, Hutcheson J, Haines GK3, Perlman H. Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis. Arthritis Rheum 2006, 54:3182-3193. 10.1002/art.22133, 17009248.
    • (2006) Arthritis Rheum , vol.54 , pp. 3182-3193
    • Scatizzi, J.C.1    Bickel, E.2    Hutcheson, J.3    Haines, G.K.3.4    Perlman, H.5
  • 15
    • 33646505131 scopus 로고    scopus 로고
    • P21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis
    • 10.2353/ajpath.2006.050555, 1606593, 16651620
    • Scatizzi JC, Hutcheson J, Bickel E, Woods JM, Klosowska K, Moore TL, Haines GK3, Perlman H. p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis. Am J Pathol 2006, 168:1531-1541. 10.2353/ajpath.2006.050555, 1606593, 16651620.
    • (2006) Am J Pathol , vol.168 , pp. 1531-1541
    • Scatizzi, J.C.1    Hutcheson, J.2    Bickel, E.3    Woods, J.M.4    Klosowska, K.5    Moore, T.L.6    Haines, G.K.3.7    Perlman, H.8
  • 16
    • 34347219754 scopus 로고    scopus 로고
    • Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis
    • Scatizzi JC, Hutcheson J, Bickel E, Haines GK3, Perlman H. Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis. Arthritis Res Ther 2007, 9:49.
    • (2007) Arthritis Res Ther , vol.9 , pp. 49
    • Scatizzi, J.C.1    Hutcheson, J.2    Bickel, E.3    Haines, G.K.3.4    Perlman, H.5
  • 17
    • 75749091858 scopus 로고    scopus 로고
    • Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis
    • 10.1002/art.27198, 2848986, 20112357
    • Scatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M, Smason A, Agrawal H, Haines GK3, Chandel NS, et al. Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum 2010, 62:441-451. 10.1002/art.27198, 2848986, 20112357.
    • (2010) Arthritis Rheum , vol.62 , pp. 441-451
    • Scatizzi, J.C.1    Hutcheson, J.2    Pope, R.M.3    Firestein, G.S.4    Koch, A.E.5    Mavers, M.6    Smason, A.7    Agrawal, H.8    Haines, G.K.3.9    Chandel, N.S.10
  • 18
    • 84860876434 scopus 로고    scopus 로고
    • Current advances in humanized mouse models
    • 10.1038/cmi.2012.2, 22327211
    • Ito R, Takahashi T, Katano I, Ito M. Current advances in humanized mouse models. Cell Mol Immunol 2012, 9:208-214. 10.1038/cmi.2012.2, 22327211.
    • (2012) Cell Mol Immunol , vol.9 , pp. 208-214
    • Ito, R.1    Takahashi, T.2    Katano, I.3    Ito, M.4
  • 19
    • 70349314352 scopus 로고    scopus 로고
    • Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice
    • Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J, Ablamunits V, Kirkiles-Smith N, Herold KC, Donis RO, et al. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Human Immunol 2009, 70:790-802.
    • (2009) Human Immunol , vol.70 , pp. 790-802
    • Lepus, C.M.1    Gibson, T.F.2    Gerber, S.A.3    Kawikova, I.4    Szczepanik, M.5    Hossain, J.6    Ablamunits, V.7    Kirkiles-Smith, N.8    Herold, K.C.9    Donis, R.O.10
  • 20
    • 79952814422 scopus 로고    scopus 로고
    • Mice with human immune system components as in vivo models for infections with human pathogens
    • 10.1038/icb.2010.151, 3087174, 21301484
    • Ramer PC, Chijioke O, Meixlsperger S, Leung CS, Munz C. Mice with human immune system components as in vivo models for infections with human pathogens. Immunol Cell Biol 2011, 89:408-416. 10.1038/icb.2010.151, 3087174, 21301484.
    • (2011) Immunol Cell Biol , vol.89 , pp. 408-416
    • Ramer, P.C.1    Chijioke, O.2    Meixlsperger, S.3    Leung, C.S.4    Munz, C.5
  • 21
    • 84862596451 scopus 로고    scopus 로고
    • Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice
    • 10.4049/jimmunol.1103660, 22611244
    • Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 2012, 188:6145-6155. 10.4049/jimmunol.1103660, 22611244.
    • (2012) J Immunol , vol.188 , pp. 6145-6155
    • Tanaka, S.1    Saito, Y.2    Kunisawa, J.3    Kurashima, Y.4    Wake, T.5    Suzuki, N.6    Shultz, L.D.7    Kiyono, H.8    Ishikawa, F.9
  • 22
    • 0042890415 scopus 로고    scopus 로고
    • Characterisation of a Freund's complete adjuvant-induced model of chronic arthritis in mice
    • 10.1016/S0165-0270(03)00147-X, 12948547
    • Chillingworth NL, Donaldson LF. Characterisation of a Freund's complete adjuvant-induced model of chronic arthritis in mice. J Neurosci Methods 2003, 128:45-52. 10.1016/S0165-0270(03)00147-X, 12948547.
    • (2003) J Neurosci Methods , vol.128 , pp. 45-52
    • Chillingworth, N.L.1    Donaldson, L.F.2
  • 23
    • 57449096122 scopus 로고    scopus 로고
    • A prescription for human immunology
    • 10.1016/j.immuni.2008.12.003, 2905652, 19100694
    • Davis MM. A prescription for human immunology. Immunity 2008, 29:835-838. 10.1016/j.immuni.2008.12.003, 2905652, 19100694.
    • (2008) Immunity , vol.29 , pp. 835-838
    • Davis, M.M.1
  • 25
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol 2004, 172:2731-2738.
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 27
    • 84859201276 scopus 로고    scopus 로고
    • Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/gammacnull mouse
    • Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K. Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/gammacnull mouse. Int Immunol 2012, 24:243-252.
    • (2012) Int Immunol , vol.24 , pp. 243-252
    • Suzuki, M.1    Takahashi, T.2    Katano, I.3    Ito, R.4    Ito, M.5    Harigae, H.6    Ishii, N.7    Sugamura, K.8
  • 29
    • 67649838584 scopus 로고    scopus 로고
    • The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice)
    • 10.1093/intimm/dxp050, 19515798
    • Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, et al. The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 2009, 21:843-858. 10.1093/intimm/dxp050, 19515798.
    • (2009) Int Immunol , vol.21 , pp. 843-858
    • Watanabe, Y.1    Takahashi, T.2    Okajima, A.3    Shiokawa, M.4    Ishii, N.5    Katano, I.6    Ito, R.7    Ito, M.8    Minegishi, M.9    Minegishi, N.10
  • 30
    • 79956073079 scopus 로고    scopus 로고
    • Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells
    • Danner R, Chaudhari SN, Rosenberger J, Surls J, Richie TL, Brumeanu TD, Casares S. Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One 2011, 6:19826.
    • (2011) PLoS One , vol.6 , pp. 19826
    • Danner, R.1    Chaudhari, S.N.2    Rosenberger, J.3    Surls, J.4    Richie, T.L.5    Brumeanu, T.D.6    Casares, S.7
  • 32
    • 80051988436 scopus 로고    scopus 로고
    • Transgenic expression of human signal regulatory protein alpha in Rag2-/-{gamma}c-/- mice improves engraftment of human hematopoietic cells in humanized mice
    • 10.1073/pnas.1109769108, 3156175, 21788509
    • Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA. Transgenic expression of human signal regulatory protein alpha in Rag2-/-{gamma}c-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A 2011, 108:13218-13223. 10.1073/pnas.1109769108, 3156175, 21788509.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13218-13223
    • Strowig, T.1    Rongvaux, A.2    Rathinam, C.3    Takizawa, H.4    Borsotti, C.5    Philbrick, W.6    Eynon, E.E.7    Manz, M.G.8    Flavell, R.A.9
  • 35
    • 0033016267 scopus 로고    scopus 로고
    • Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data
    • 10.1002/1529-0131(199904)42:3<498::AID-ANR15>3.0.CO;2-A, 10088773
    • Bendele A, McAbee T, Sennello G, Frazier J, Chlipala E, McCabe D. Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data. Arthritis Rheum 1999, 42:498-506. 10.1002/1529-0131(199904)42:3<498::AID-ANR15>3.0.CO;2-A, 10088773.
    • (1999) Arthritis Rheum , vol.42 , pp. 498-506
    • Bendele, A.1    McAbee, T.2    Sennello, G.3    Frazier, J.4    Chlipala, E.5    McCabe, D.6
  • 36
    • 0034544946 scopus 로고    scopus 로고
    • Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis
    • 10.1002/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M, 11145022
    • Bendele AM, Chlipala ES, Scherrer J, Frazier J, Sennello G, Rich WJ, Edwards CK3. Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis. Arthritis Rheum 2000, 43:2648-2659. 10.1002/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M, 11145022.
    • (2000) Arthritis Rheum , vol.43 , pp. 2648-2659
    • Bendele, A.M.1    Chlipala, E.S.2    Scherrer, J.3    Frazier, J.4    Sennello, G.5    Rich, W.J.6    Edwards, C.K.3.7
  • 37
    • 0032873289 scopus 로고    scopus 로고
    • Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats
    • 10.1007/s000110050486, 10493163
    • Bendele AM, McComb J, Gould T, Frazier J, Chlipala ES, Seely J, Kieft G, Wolf J, Edwards CK3. Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats. Inflamm Res 1999, 48:453-460. 10.1007/s000110050486, 10493163.
    • (1999) Inflamm Res , vol.48 , pp. 453-460
    • Bendele, A.M.1    McComb, J.2    Gould, T.3    Frazier, J.4    Chlipala, E.S.5    Seely, J.6    Kieft, G.7    Wolf, J.8    Edwards, C.K.3.9
  • 38
    • 0033067522 scopus 로고    scopus 로고
    • Antiarthritic activity of soluble tumor necrosis factor receptor type I forms in adjuvant arthritis: correlation of plasma levels with efficacy
    • McComb J, Gould T, Chlipala E, Sennelo G, Frazier J, Kieft G, Seely J, Edwards CK3, Bendele A. Antiarthritic activity of soluble tumor necrosis factor receptor type I forms in adjuvant arthritis: correlation of plasma levels with efficacy. J Rheumatol 1999, 26:1347-1351.
    • (1999) J Rheumatol , vol.26 , pp. 1347-1351
    • McComb, J.1    Gould, T.2    Chlipala, E.3    Sennelo, G.4    Frazier, J.5    Kieft, G.6    Seely, J.7    Edwards, C.K.3.8    Bendele, A.9
  • 39
    • 0032884904 scopus 로고    scopus 로고
    • Effects of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) alone and in combination with methotrexate in adjuvant arthritic rats
    • Bendele AM, McComb J, Gould T, Frazier J, Chlipala E, Seely J, Kieft G, Edwards CK3. Effects of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) alone and in combination with methotrexate in adjuvant arthritic rats. Clin Exper Rheum 1999, 17:553-560.
    • (1999) Clin Exper Rheum , vol.17 , pp. 553-560
    • Bendele, A.M.1    McComb, J.2    Gould, T.3    Frazier, J.4    Chlipala, E.5    Seely, J.6    Kieft, G.7    Edwards, C.K.3.8
  • 40
    • 79959484284 scopus 로고    scopus 로고
    • HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells
    • 10.2337/db10-1287, 3114397, 21521873
    • Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, et al. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 2011, 60:1726-1733. 10.2337/db10-1287, 3114397, 21521873.
    • (2011) Diabetes , vol.60 , pp. 1726-1733
    • Whitfield-Larry, F.1    Young, E.F.2    Talmage, G.3    Fudge, E.4    Azam, A.5    Patel, S.6    Largay, J.7    Byrd, W.8    Buse, J.9    Calikoglu, A.S.10
  • 41
    • 77956384921 scopus 로고    scopus 로고
    • Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice
    • 10.2337/db10-0323, 2927949, 20570944
    • Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, et al. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes 2010, 59:2265-2270. 10.2337/db10-0323, 2927949, 20570944.
    • (2010) Diabetes , vol.59 , pp. 2265-2270
    • Brehm, M.A.1    Bortell, R.2    Diiorio, P.3    Leif, J.4    Laning, J.5    Cuthbert, A.6    Yang, C.7    Herlihy, M.8    Burzenski, L.9    Gott, B.10
  • 42
    • 80052314685 scopus 로고    scopus 로고
    • Engraftment of PBMC from SLE and APS donors into BALB-Rag2-/-IL2Rgc-/- mice: A promising model for studying human disease
    • 10.1002/art.30424, 3168580, 21560114
    • Andrade D, Redecha PB, Vukelic M, Qing X, Perino G, Salmon JE, Koo GC. Engraftment of PBMC from SLE and APS donors into BALB-Rag2-/-IL2Rgc-/- mice: A promising model for studying human disease. Arthritis Rheum 2011, 63:2764-2773. 10.1002/art.30424, 3168580, 21560114.
    • (2011) Arthritis Rheum , vol.63 , pp. 2764-2773
    • Andrade, D.1    Redecha, P.B.2    Vukelic, M.3    Qing, X.4    Perino, G.5    Salmon, J.E.6    Koo, G.C.7


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