Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2 -/-IL-2Rγ-/- mice: A promising model for studying human disease

Arthritis and Rheumatism

Volumn 63, Issue 9, 2011, Pages 2764-2773

  Andrade, Danieli ^a   Redecha, Patricia B ^a   Vukelic, Milena ^a   Qing, Xiaoping ^a   Perino, Giorgio ^a   Salmon, Jane E ^a   Koo, Gloria C ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN ANTIBODY; CD45 ANTIGEN; DOUBLE STRANDED DNA ANTIBODY; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN G; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; WARFARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BONE MARROW; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DENSITY; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENGRAFTMENT; FEMALE; GLOMERULUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IRRADIATION; LIVER; LUNG; MALE; MICROTHROMBUS; MONOCYTE; MONONUCLEAR CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; SPLEEN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ANIMALS; ANTIPHOSPHOLIPID SYNDROME; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED;

EID: 80052314685     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30424     Document Type: Article

References (34)

1. Rahman A, Isenberg DA,. Systemic lupus erythematosus. N Engl J Med 2008; 358: 929-39. (Pubitemid 351397092)
2. Salmon JE, Girardi G,. Theodore E. Antiphospholipid syndrome revisited: a disorder initiated by inflammation. Trans Am Clin Climatol Assoc 2007; 118: 99-114.
3. Eisenberg R,. Why can't we find a new treatment for SLE? J Autoimmun 2009; 32: 223-30.
4. Ryan MJ,. The pathophysiology of hypertension in systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 2009; 296: R1258-67.
5. Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004; 304: 104-7. (Pubitemid 38451466)
6. Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992; 68: 855-67.
7. Ito M, Kobayashi K, Nakahata T,. NOD/Shi-scid IL2rγ (null) (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 2008; 324: 53-76.
8. Shultz LD, Ishikawa F, Greiner DL,. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7: 118-30. (Pubitemid 46174859)
9. Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, Riblet R,. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A 1995; 92: 10792-105.
10. Araki R, Fujimori A, Hamatani K, Mita K, Saito T, Mori M, et al. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A 1997; 94: 2438-43. (Pubitemid 27136893)
11. Koo GC, Hasan A, O'Reilly RJ,. Use of humanized severe combined immunodeficient mice for human vaccine development. Expert Rev Vaccines 2009; 8: 113-20.
12. Mosier DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA,. Human immunodeficiency virus infection of human-PBL-SCID mice. Science 1991; 251: 791-4. (Pubitemid 21926171)
13. Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, et al. Highly sensitive model for xenogeneic GVHD using severe immunodeficient NOG mice. Transplantation 2009; 87: 1654-8.
14. Duchosal MA, McConahey PJ, Robinson CA, Dixon FJ,. Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. J Exp Med 1990; 172: 985-8. (Pubitemid 20301248)
15. Mauermann N, Sthoeger Z, Zinger H, Mozes E,. Amelioration of lupus manifestations by a peptide based on the complementarity determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patients. Clin Exp Immunol 2004; 137: 513-20. (Pubitemid 39128077)
16. Bohm I,. Apoptosis: the link between autoantibodies and leuko-/lymphocytopenia in patients with lupus erythematosus. Scand J Rheumatol 2004; 33: 409-16. (Pubitemid 40006891)
17. Vila LM, Alarcon GS, McGwin G Jr, Bastian HM, Fessler BJ, Reveille JD, for the LUMINA Study Group. Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual. Arthritis Rheum 2006; 55: 799-806. (Pubitemid 44619195)
18. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-7. (Pubitemid 13221242)
19. Blanco P, Pitard V, Viallard JF, Taupin JL, Pellegrin JL, Moreau JF,. Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2005; 52: 201-11. (Pubitemid 40129249)
20. Camacho RE, Wnek R, Fischer P, Shah K, Zaller DM, Woods A, et al. Characterization of the NOD/scid-[Tg]DR1 mouse expressing HLA-DRB1*01 transgene: a model of SCID-hu mouse for vaccine development. Exp Hematol 2007; 35: 1219-30. (Pubitemid 47088778)
21. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004; 15: 241-50. (Pubitemid 38140764)
22. Mahajan SK, Ordonez NG, Feitelson PJ, Lim VS, Spargo BH, Katz AI,. Lupus nephropathy without clinical renal involvement. Medicine (Baltimore) 1977; 56: 493-501. (Pubitemid 8229838)
23. Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, et al. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol 2010; 185: 1912-9.
24. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, et al. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor γ chain gene. Clin Immunol 2008; 126: 303-14.
25. Salmon JE, Girardi G, Holers VM,. Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 2002; 61 Suppl II: ii46-50. (Pubitemid 35221713)
26. Seshan SV, Franzke CW, Redecha P, Monestier M, Mackman N, Girardi G,. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Blood 2009; 114: 1675-83.
27. King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, et al. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor γ chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 2009; 157: 104-18.
28. + Treg cells are associated with immunological remission of lupus. J Immunol 2009; 183: 6346-58.
29. Horwitz DA,. Regulatory T cells in systemic lupus erythematosus: past, present and future. Arthritis Res Ther 2008; 10: 227.
30. Zhao W, Thacker SG, Hodgin JB, Zhang H, Wang JH, Park JL, et al. The peroxisome proliferator-activated receptor γ agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus. J Immunol 2009; 183: 2729-40.
31. Triantafyllopoulou A, Franzke CW, Seshan SV, Perino G, Kalliolias GD, Ramanujam M, et al. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A 2010; 107: 3012-7.
32. Liu Z, Bethunaickan R, Huang W, Lodhi U, Solano I, Madaio MP, et al. Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner. Arthritis Rheum 2011; 63: 219-29.
33. Steinmetz OM, Velden J, Kneissler U, Marx M, Klein A, Helmchen U, et al. Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis. Kidney Int 2008; 74: 448-57.
34. Dolff S, Abdulahad WH, van Dijk MC, Limburg PC, Kallenberg CG, Bijl M,. Urinary T cells in active lupus nephritis show an effector memory phenotype. Ann Rheum Dis 2010; 69: 2034-41.