메뉴 건너뛰기




Volumn 4, Issue 5, 2012, Pages 1104-1108

Endogenous cGMP-dependent protein kinase reverses EGF-induced MAPK/ERK signal transduction through phosphorylation of VASP at Ser239

Author keywords

CGMP dependent protein kinase; Endogenous; MAPK ERK; Small cell lung carcinoma; VASP

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SERINE; SOS PROTEIN; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 84866094136     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.851     Document Type: Article
Times cited : (9)

References (31)
  • 2
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • Wheeler DL, Dunn EF and Harari PM: Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 7: 493-507, 2010.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 493-507
    • Wheeler, D.L.1    Dunn, E.F.2    Harari, P.M.3
  • 3
    • 0032915392 scopus 로고    scopus 로고
    • Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
    • Hackel PO, Zwick E, Prenzel N and Ullrich A: Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Curr Opin Cell Biol 11: 184-189, 1999.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 184-189
    • Hackel, P.O.1    Zwick, E.2    Prenzel, N.3    Ullrich, A.4
  • 4
    • 78650977190 scopus 로고    scopus 로고
    • EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
    • Jiang H, Grenley MO, Bravo MJ, Blumhagen RZ and Edgar BA: EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8: 84-95, 2011.
    • (2011) Cell Stem Cell , vol.8 , pp. 84-95
    • Jiang, H.1    Grenley, M.O.2    Bravo, M.J.3    Blumhagen, R.Z.4    Edgar, B.A.5
  • 6
    • 0031127304 scopus 로고    scopus 로고
    • Cell cycle: Routine role for Ras
    • Downward J: Cell cycle: routine role for Ras. Curr Biol 7: 258-260, 1997.
    • (1997) Curr Biol , vol.7 , pp. 258-260
    • Downward, J.1
  • 7
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W: Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. BiochemJ2: 289-305, 2000.
    • (2000) BiochemJ , vol.2 , pp. 289-305
    • Kolch, W.1
  • 8
    • 0037230196 scopus 로고    scopus 로고
    • Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling
    • Stockand JD and Meszaros JG: Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am J Physiol Heart Circ Physiol 284: H176-H184, 2003.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Stockand, J.D.1    Meszaros, J.G.2
  • 9
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • Martindale JL and Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192: 1-15, 2002.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 10
    • 0031172791 scopus 로고    scopus 로고
    • Characterization of the human gene encoding the type Ialpha and type Ibeta cGMP-dependent protein kinase (PRKG1)
    • Orstavik S, Natarajan V, Taskén K, Jahnsen T and Sandberg M: Characterization of the human gene encoding the type Ialpha and type Ibeta cGMP-dependent protein kinase (PRKG1). Genomics 42: 311-318, 1997.
    • (1997) Genomics , vol.42 , pp. 311-318
    • Orstavik, S.1    Natarajan, V.2    Taskén, K.3    Jahnsen, T.4    Sandberg, M.5
  • 11
    • 0029114468 scopus 로고
    • Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator
    • Markert T, Vaandrager AB, Gambaryan S, Pöhler D, HäuslerC, Walter U, De Jonge HR, Jarchau T and Lohmann SM: Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. J Clin Invest 96: 822-830, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 822-830
    • Markert, T.1    Vaandrager, A.B.2    Gambaryan, S.3    Pöhler, D.4    Häusler, C.5    Walter, U.6    De Jonge, H.R.7    Jarchau, T.8    Lohmann, S.M.9
  • 12
    • 0032725027 scopus 로고    scopus 로고
    • Cyclic nucleotides and phosphodiesterases in platelets
    • Haslam RJ, Dickinson NT and Jang EK: Cyclic nucleotides and phosphodiesterases in platelets. Thromb Haemost 82: 412-423, 1999.
    • (1999) Thromb Haemost , vol.82 , pp. 412-423
    • Haslam, R.J.1    Dickinson, N.T.2    Jang, E.K.3
  • 14
    • 0035968197 scopus 로고    scopus 로고
    • Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta
    • Ammendola A, Geiselhöringer A, Hofmann F and SchlossmannJ: Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. J Biol Chem 276: 24153-24159, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 24153-24159
    • Ammendola, A.1    Geiselhöringer, A.2    Hofmann, F.3    Schlossmann, J.4
  • 15
    • 4644269783 scopus 로고    scopus 로고
    • The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents
    • Russo I, Doronzo G, De Salve A, Mattiello L, Trovati M and Anfossi G: The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents. Thromb Res 114: 265-273, 2004.
    • (2004) Thromb Res , vol.114 , pp. 265-273
    • Russo, I.1    Doronzo, G.2    De Salve, A.3    Mattiello, L.4    Trovati, M.5    Anfossi, G.6
  • 16
    • 69849089410 scopus 로고    scopus 로고
    • Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines
    • Swartling FJ, Ferletta M, Kastemar M, Weiss WA and Westermark B: Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. Oncogene 28: 3121-3131, 2009.
    • (2009) Oncogene , vol.28 , pp. 3121-3131
    • Swartling, F.J.1    Ferletta, M.2    Kastemar, M.3    Weiss, W.A.4    Westermark, B.5
  • 17
    • 77950845594 scopus 로고    scopus 로고
    • Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823
    • Chen YC, Ren F, Sang JR, Tao Y and Xu WX: Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823. Mol Med Report 3: 361-366, 2010.
    • (2010) Mol Med Report , vol.3 , pp. 361-366
    • Chen, Y.C.1    Ren, F.2    Sang, J.R.3    Tao, Y.4    Xu, W.X.5
  • 18
    • 84862907707 scopus 로고    scopus 로고
    • Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells
    • Wu Y, Chen YC, Qu R, Lan T and Sang JR: Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. Oncol Rep 27: 553-558, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 553-558
    • Wu, Y.1    Chen, Y.C.2    Qu, R.3    Lan, T.4    Sang, J.R.5
  • 19
    • 0036320467 scopus 로고    scopus 로고
    • Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization
    • Geese M, Loureiro JJ, Bear JE, Wehland J, Gertler FB and SechiAS: Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Mol Biol Cell13: 2383-2396, 2002.
    • (2002) Mol Biol Cell , vol.13 , pp. 2383-2396
    • Geese, M.1    Loureiro, J.J.2    Bear, J.E.3    Wehland, J.4    Gertler, F.B.5    Sechi, A.S.6
  • 20
    • 0036468677 scopus 로고    scopus 로고
    • Germline transmission and tissue-specific expression of transgenes delivered by lentiviralvectors
    • Lois C, Hong EJ, Pease S, Brown EJ and Baltimore D: Germline transmission and tissue-specific expression of transgenes delivered by lentiviralvectors. Science 295: 868-872, 2002.
    • (2002) Science , vol.295 , pp. 868-872
    • Lois, C.1    Hong, E.J.2    Pease, S.3    Brown, E.J.4    Baltimore, D.5
  • 21
    • 0347003599 scopus 로고    scopus 로고
    • Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins
    • Zhang XY, La Russa VF and Reiser J: Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins. J Virol 78: 1219-1229, 2004.
    • (2004) J Virol , vol.78 , pp. 1219-1229
    • Zhang, X.Y.1    La Russa, V.F.2    Reiser, J.3
  • 22
    • 0031055415 scopus 로고    scopus 로고
    • Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
    • de Rooij J and Bos JL: Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene14: 623-625, 1997.
    • (1997) Oncogene , vol.14 , pp. 623-625
    • de Rooij, J.1    Bos, J.L.2
  • 23
    • 0028869124 scopus 로고
    • Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin
    • Draijer R, Vaandrager AB, Nolte C, de Jonge HR, Walter U and van Hinsbergh VW: Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin. Circ Res 77: 897-905, 1995.
    • (1995) Circ Res , vol.77 , pp. 897-905
    • Draijer, R.1    Vaandrager, A.B.2    Nolte, C.3    de Jonge, H.R.4    Walter, U.5    van Hinsbergh, V.W.6
  • 24
    • 0028303913 scopus 로고
    • cAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets
    • Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J and WalterU: cAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J Biol Chem 269: 14509-14517, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 14509-14517
    • Butt, E.1    Abel, K.2    Krieger, M.3    Palm, D.4    Hoppe, V.5    Hoppe, J.6    Walter, U.7
  • 25
    • 0030592559 scopus 로고    scopus 로고
    • Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    • Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P: Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell 87: 227-239, 1996.
    • (1996) Cell , vol.87 , pp. 227-239
    • Gertler, F.B.1    Niebuhr, K.2    Reinhard, M.3    Wehland, J.4    Soriano, P.5
  • 26
    • 0034680938 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains
    • Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C and Gertler FB: cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. J Biol Chem 275: 36143-36151, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 36143-36151
    • Lambrechts, A.1    Kwiatkowski, A.V.2    Lanier, L.M.3    Bear, J.E.4    Vandekerckhove, J.5    Ampe, C.6    Gertler, F.B.7
  • 27
    • 0035803494 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: A novel regulatory mechanism for tyrosine kinase signaling
    • Li S, Couvillon AD, Brasher BB and Van Etten RA: Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. EMBO J 20: 6793-6804, 2001.
    • (2001) EMBO J , vol.20 , pp. 6793-6804
    • Li, S.1    Couvillon, A.D.2    Brasher, B.B.3    Van Etten, R.A.4
  • 28
    • 0033959896 scopus 로고    scopus 로고
    • A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
    • Rodrigues GA, Falasca M, Zhang Z, Ong SH and Schlessinger J: A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol 20: 1448-1459, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 1448-1459
    • Rodrigues, G.A.1    Falasca, M.2    Zhang, Z.3    Ong, S.H.4    Schlessinger, J.5
  • 29
    • 18944380695 scopus 로고    scopus 로고
    • Insights into cGMP signalling derived from cGMP kinase knockout mice
    • Schlossmann J, Feil R and Hofmann F: Insights into cGMP signalling derived from cGMP kinase knockout mice. Front Biosci 10: 1279-1289, 2005.
    • (2005) Front Biosci , vol.10 , pp. 1279-1289
    • Schlossmann, J.1    Feil, R.2    Hofmann, F.3
  • 30
    • 0344014113 scopus 로고    scopus 로고
    • Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells
    • Cook AL and Haynes JM: Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cell Signal 16: 253-261, 2004.
    • (2004) Cell Signal , vol.16 , pp. 253-261
    • Cook, A.L.1    Haynes, J.M.2
  • 31
    • 33751424711 scopus 로고    scopus 로고
    • Phosphorylation of the PKG substrate, vasodilator-stimulated phosphoprotein (VASP), in human cultured prostatic stromal cells
    • Cook AL and Haynes JM: Phosphorylation of the PKG substrate, vasodilator-stimulated phosphoprotein (VASP), in human cultured prostatic stromal cells. Nitric Oxide 16: 10-17, 2007.
    • (2007) Nitric Oxide , vol.16 , pp. 10-17
    • Cook, A.L.1    Haynes, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.