메뉴 건너뛰기




Volumn 26, Issue 9, 2012, Pages 1301-1307

Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells

Author keywords

Airway; MUC5AC; silibinin

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR; MUCIN 5AC; PHORBOL 13 ACETATE 12 MYRISTATE; SILIBININ; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84866062909     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3727     Document Type: Article
Times cited : (22)

References (38)
  • 1
    • 77953023898 scopus 로고    scopus 로고
    • Downregulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis
    • Bannwart CF, Nakaira-Takahagi E, Golim MA, et al., 2010. Downregulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis. Life Sci 86 (23-24): 880-886.
    • (2010) Life Sci , vol.86 , Issue.2324 , pp. 880-886
    • Bannwart, C.F.1    Nakaira-Takahagi, E.2    Golim, M.A.3
  • 2
    • 33744824356 scopus 로고    scopus 로고
    • Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway
    • Chen PN, Hsieh YS, Chiang CL, Chiou HL, Yang SF, Chu SC,. 2006. Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway. J Dent Res 85 (3): 220-225.
    • (2006) J Dent Res , vol.85 , Issue.3 , pp. 220-225
    • Chen, P.N.1    Hsieh, Y.S.2    Chiang, C.L.3    Chiou, H.L.4    Yang, S.F.5    Chu, S.C.6
  • 3
    • 0038688427 scopus 로고    scopus 로고
    • Cytokine regulation of mucus production in a model of allergic asthma
    • Cohn L, Whittaker L, Niu N, Homer RJ,. 2002. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp 248: 201-213.
    • (2002) Novartis Found Symp , vol.248 , pp. 201-213
    • Cohn, L.1    Whittaker, L.2    Niu, N.3    Homer, R.J.4
  • 4
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam JD, Lebovitz RM, Roeder RG,. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11 (5): 1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , Issue.5 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 5
    • 0033089160 scopus 로고    scopus 로고
    • TNF-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro
    • Fischer BM, Rochelle LG, Voynow JA, Akley NJ, Adler KB,. 1999. TNF-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. Am J Respir Cell Mol Biol 20: 413-422.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 413-422
    • Fischer, B.M.1    Rochelle, L.G.2    Voynow, J.A.3    Akley, N.J.4    Adler, K.B.5
  • 6
    • 0022629214 scopus 로고
    • Extracellular ATP: Effects, sources and fate
    • Gordon JL,. 1986. Extracellular ATP: effects, sources and fate. Biochem J 233 (2): 309-319.
    • (1986) Biochem J , vol.233 , Issue.2 , pp. 309-319
    • Gordon, J.L.1
  • 7
    • 34248220602 scopus 로고    scopus 로고
    • Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells
    • Heo HJ, Kim C, Lee HJ, et al., 2007a. Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. Phytother Res 21 (5): 462-465.
    • (2007) Phytother Res , vol.21 , Issue.5 , pp. 462-465
    • Heo, H.J.1    Kim, C.2    Lee, H.J.3
  • 8
    • 37849050920 scopus 로고    scopus 로고
    • Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells
    • Heo HJ, Lee HJ, Kim YS, et al., 2007b. Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells. Phytother Res 21 (12): 1130-1134
    • (2007) Phytother Res , vol.21 , Issue.12 , pp. 1130-1134
    • Heo, H.J.1    Lee, H.J.2    Kim, Y.S.3
  • 9
    • 70349918769 scopus 로고    scopus 로고
    • Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells
    • Heo HJ, Lee SY, Lee MN, Lee HJ, Seok JH, Lee CJ,. 2009. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother Res 23 (10): 1458-1461.
    • (2009) Phytother Res , vol.23 , Issue.10 , pp. 1458-1461
    • Heo, H.J.1    Lee, S.Y.2    Lee, M.N.3    Lee, H.J.4    Seok, J.H.5    Lee, C.J.6
  • 10
    • 7944225451 scopus 로고    scopus 로고
    • PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells via PKC, EGF/TGF-alpha, Ras/Raf, MEK, REK and Sp1-dependent mechanisms
    • Hewson CA, Edbrooke MR, Johnston SL,. 2004. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells via PKC, EGF/TGF-alpha, Ras/Raf, MEK, REK and Sp1-dependent mechanisms. J Mol Biol 344: 683-695.
    • (2004) J Mol Biol , vol.344 , pp. 683-695
    • Hewson, C.A.1    Edbrooke, M.R.2    Johnston, S.L.3
  • 11
    • 35248818831 scopus 로고    scopus 로고
    • Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer
    • Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS,. 2007. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 143 (1): 58-65.
    • (2007) J Surg Res , vol.143 , Issue.1 , pp. 58-65
    • Hogan, F.S.1    Krishnegowda, N.K.2    Mikhailova, M.3    Kahlenberg, M.S.4
  • 12
    • 0032739875 scopus 로고    scopus 로고
    • Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon
    • Hong DH, Petrovics G, Anderson WB, Forstner J, Forstner G,. 1999. Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon. Am J Physiol 277: G1041-G1047.
    • (1999) Am J Physiol , vol.277
    • Hong, D.H.1    Petrovics, G.2    Anderson, W.B.3    Forstner, J.4    Forstner, G.5
  • 13
    • 77956569078 scopus 로고    scopus 로고
    • Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation
    • Hou YC, Liou KT, Chern CM, et al., 2010. Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. Phytomedicine 17 (12): 963-973.
    • (2010) Phytomedicine , vol.17 , Issue.12 , pp. 963-973
    • Hou, Y.C.1    Liou, K.T.2    Chern, C.M.3
  • 15
    • 0031472174 scopus 로고    scopus 로고
    • Airway goblet cell mucin: Its structure and regulation of secretion
    • Kim KC, McCracken K, Lee BC, et al., 1997. Airway goblet cell mucin: its structure and regulation of secretion. Eur Respir J 10: 2644-2649.
    • (1997) Eur Respir J , vol.10 , pp. 2644-2649
    • Kim, K.C.1    McCracken, K.2    Lee, B.C.3
  • 16
    • 0006643756 scopus 로고    scopus 로고
    • Inhibition of mucin release from airway goblet cells by polycationic peptides
    • Ko KH, Lee CJ, Shin CY, Jo M, Kim KC,. 1999. Inhibition of mucin release from airway goblet cells by polycationic peptides. Am J Physiol 277: L811-L815.
    • (1999) Am J Physiol , vol.277
    • Ko, K.H.1    Lee, C.J.2    Shin, C.Y.3    Jo, M.4    Kim, K.C.5
  • 17
    • 0036846453 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor
    • Kohri K, Ueki IF, Shim JJ, et al., 2002. Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J 20 (5): 1263-1270.
    • (2002) Eur Respir J , vol.20 , Issue.5 , pp. 1263-1270
    • Kohri, K.1    Ueki, I.F.2    Shim, J.J.3
  • 18
    • 0038502409 scopus 로고    scopus 로고
    • Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells
    • Lee CJ, Lee JH, Seok JH, et al., 2003. Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. Planta Med 69: 523-526.
    • (2003) Planta Med , vol.69 , pp. 523-526
    • Lee, C.J.1    Lee, J.H.2    Seok, J.H.3
  • 19
    • 2442540251 scopus 로고    scopus 로고
    • Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells
    • Lee CJ, Lee JH, Seok JH, et al., 2004a. Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells. Phytother Res 18: 301-305.
    • (2004) Phytother Res , vol.18 , pp. 301-305
    • Lee, C.J.1    Lee, J.H.2    Seok, J.H.3
  • 20
    • 11944254206 scopus 로고    scopus 로고
    • Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells
    • Lee CJ, Seok JH, Hur GM, et al., 2004b. Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. Planta Med 70: 1119-1122.
    • (2004) Planta Med , vol.70 , pp. 1119-1122
    • Lee, C.J.1    Seok, J.H.2    Hur, G.M.3
  • 21
    • 33846326821 scopus 로고    scopus 로고
    • Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells
    • Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS,. 2007. Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochem Biophys Res Commun 354 (1): 165-171.
    • (2007) Biochem Biophys Res Commun , vol.354 , Issue.1 , pp. 165-171
    • Lee, S.O.1    Jeong, Y.J.2    Im, H.G.3    Kim, C.H.4    Chang, Y.C.5    Lee, I.S.6
  • 22
    • 0031029855 scopus 로고    scopus 로고
    • Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease
    • Li JD, Dohrman AF, Gallup M, et al., 1997. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A 94 (3): 967-972.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.3 , pp. 967-972
    • Li, J.D.1    Dohrman, A.F.2    Gallup, M.3
  • 23
    • 53949096956 scopus 로고    scopus 로고
    • Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
    • Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y,. 2008. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 272 (1): 61-69.
    • (2008) Cancer Lett , vol.272 , Issue.1 , pp. 61-69
    • Li, L.1    Gao, Y.2    Zhang, L.3    Zeng, J.4    He, D.5    Sun, Y.6
  • 24
    • 37349012896 scopus 로고    scopus 로고
    • Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury
    • Ligeret H, Brault A, Vallerand D, Haddad Y, Haddad PS,. 2008. Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury. J Ethnopharmacol 115 (3): 507-514.
    • (2008) J Ethnopharmacol , vol.115 , Issue.3 , pp. 507-514
    • Ligeret, H.1    Brault, A.2    Vallerand, D.3    Haddad, Y.4    Haddad, P.S.5
  • 25
    • 76649085810 scopus 로고    scopus 로고
    • Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
    • Momeny M, Malehmir M, Zakidizaji M, et al., 2010. Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9. Anticancer Drugs 21 (3): 252-260.
    • (2010) Anticancer Drugs , vol.21 , Issue.3 , pp. 252-260
    • Momeny, M.1    Malehmir, M.2    Zakidizaji, M.3
  • 26
    • 0035989732 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells
    • Park SJ, Kang SY, Kim NS, Kim HM,. 2002. Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells. Immunopharmacol Immunotoxicol 24 (2): 211-226.
    • (2002) Immunopharmacol Immunotoxicol , vol.24 , Issue.2 , pp. 211-226
    • Park, S.J.1    Kang, S.Y.2    Kim, N.S.3    Kim, H.M.4
  • 27
    • 77950540443 scopus 로고    scopus 로고
    • Identification of hepatoprotective flavonolignans from silymarin
    • Polyak SJ, Morishima C, Lohmann V, et al., 2010. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci USA 107 (13): 5995-5999.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.13 , pp. 5995-5999
    • Polyak, S.J.1    Morishima, C.2    Lohmann, V.3
  • 28
    • 33645519443 scopus 로고    scopus 로고
    • Treatment of airway mucus hypersecretion
    • Rogers DF, Barnes PJ,. 2006. Treatment of airway mucus hypersecretion. Ann Med 38 (2): 116-125.
    • (2006) Ann Med , vol.38 , Issue.2 , pp. 116-125
    • Rogers, D.F.1    Barnes, P.J.2
  • 29
    • 0141816747 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells
    • Shao MX, Ueki IF, Nadel JA,. 2003. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci USA 100: 11618-11623.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11618-11623
    • Shao, M.X.1    Ueki, I.F.2    Nadel, J.A.3
  • 30
    • 0041874952 scopus 로고    scopus 로고
    • In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells
    • Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y,. 2003. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am J Respir Crit Care Med 168 (5): 581-587.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.5 , pp. 581-587
    • Shimizu, T.1    Shimizu, S.2    Hattori, R.3    Gabazza, E.C.4    Majima, Y.5
  • 31
    • 36949029439 scopus 로고    scopus 로고
    • Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft
    • Singh RP, Deep G, Blouin MJ, Pollak MN, Agarwal R,. 2007. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis 28 (12): 2567-2574.
    • (2007) Carcinogenesis , vol.28 , Issue.12 , pp. 2567-2574
    • Singh, R.P.1    Deep, G.2    Blouin, M.J.3    Pollak, M.N.4    Agarwal, R.5
  • 32
    • 59449085306 scopus 로고    scopus 로고
    • Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
    • Singh RP, Raina K, Sharma G, Agarwal R,. 2008. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 14 (23): 7773-7780.
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7773-7780
    • Singh, R.P.1    Raina, K.2    Sharma, G.3    Agarwal, R.4
  • 33
    • 0037593635 scopus 로고    scopus 로고
    • IL-1beta and TNF-alpha induced MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinase-MSK1-CREB activation in human airway epithelial cells
    • Song KS, Lee WJ, Chung KC, et al., 2003. IL-1beta and TNF-alpha induced MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinase-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 278 (26): 23243-23250.
    • (2003) J Biol Chem , vol.278 , Issue.26 , pp. 23243-23250
    • Song, K.S.1    Lee, W.J.2    Chung, K.C.3
  • 34
    • 0033020245 scopus 로고    scopus 로고
    • Epidermal growth factor system regulates mucin production in airways
    • Takeyama K, Dabbagh K, Lee HM, et al., 1999. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 96: 3081-3086.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3081-3086
    • Takeyama, K.1    Dabbagh, K.2    Lee, H.M.3
  • 35
    • 0034141938 scopus 로고    scopus 로고
    • Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: Role of neutrophils
    • Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA,. 2000. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol 164 (3): 1546-1552.
    • (2000) J Immunol , vol.164 , Issue.3 , pp. 1546-1552
    • Takeyama, K.1    Dabbagh, K.2    Jeong Shim, J.3    Dao-Pick, T.4    Ueki, I.F.5    Nadel, J.A.6
  • 36
    • 67349165577 scopus 로고    scopus 로고
    • Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
    • Trappoliere M, Caligiuri A, Schmid M, et al., 2009. Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. J Hepatol 50 (6): 1102-1111.
    • (2009) J Hepatol , vol.50 , Issue.6 , pp. 1102-1111
    • Trappoliere, M.1    Caligiuri, A.2    Schmid, M.3
  • 37
    • 60249095813 scopus 로고    scopus 로고
    • Mucins, mucus and sputum
    • Voynow JA, Rubin BK,. 2009. Mucins, mucus and sputum. Chest 135 (2): 505-512.
    • (2009) Chest , vol.135 , Issue.2 , pp. 505-512
    • Voynow, J.A.1    Rubin, B.K.2
  • 38
    • 0023874613 scopus 로고
    • Membrane differentiation markers of airway epithelial secretory cells
    • Wasano K, Kim KC, Niles RM, Brody JS,. 1988. Membrane differentiation markers of airway epithelial secretory cells. J Histochem Cytochem 36: 167-178.
    • (1988) J Histochem Cytochem , vol.36 , pp. 167-178
    • Wasano, K.1    Kim, K.C.2    Niles, R.M.3    Brody, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.