Tumor necrosis factor-α stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 3, 1999, Pages 413-422

  Fischer, Bernard M ^b   Rochelle, Lori G ^b   Voynow, Judith A ^b   Akley, Nancy J ^b   Adler, Kenneth B ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAVIA PORCELLUS; SUS SCROFA;

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; MUCIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLCHOLINE SPECIFIC PHOSPHOLIPASE C; PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C; PHOSPHOLIPASE C; PROTEIN KINASE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; FEMALE; GUINEA PIG; IMMUNOLOGY; MALE; METABOLISM; SECRETION; SIGNAL TRANSDUCTION; TRACHEA;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EPITHELIAL CELLS; FEMALE; GUANYLATE CYCLASE; GUINEA PIGS; MALE; MODELS, BIOLOGICAL; MUCINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033089160     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.3.3393     Document Type: Article

References (53)

1. Prenzetti, L. M., P. M. Paciorek, S. A. Tannu, N. C. Rinaldi, J. E. Tocker, M. A. Wasserman, and P. R. Gater. 1996. Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the lung. J. Pharmacol. Exp. Ther. 278:847-853.
2. Cohn, L. A., B. M. Fischer, T. M. Krunkosky, D. T. Wright, and K. B. Adler. 1997. Airway epithelium in asthma. In Allergy and Allergic Diseases. A. B. Kay, editor. Blackwell Science Ltd., Oxford, UK. 263-283.
3. Suter, P. M., S. Suter, E. Girardin, P. Roux-Lombard, G. E. Grau, and J. M. Dayer. 1992. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am. Rev. Respir. Dis. 145:1016-1022.
4. Adler, K. B., B. M. Fischer, H. Li, N. H. Choe, and D. T. Wright. 1995. Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. Am. J. Respir. Cell Mol. Biol. 13:526-530.
5. Levine, S. J., P. Larivee, C. Logun, C. W. Angus, F. P. Ognibene, and J. H. Shelhamer. 1995. Tumor necrosis factor-α induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 12:196-204.
6. Kharitonov, S. A., D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shinebourne, and P. J. Barnes. 1994. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343:133-135.
7. Hamid, Q., D. R. Springall, V. Riveros-Moreno, P. Chanez, P. Howarth, A. Redington, J. Bousquet, P. Godard, S. Holgate, and J. M. Polak. 1993. Induction of nitric oxide synthase in asthma, Lancet 342:1510-1513.
8. Kharitonov, S. A., A. U. Wells, B. J. O'Connor, P. J. Cole, D. M. Hansell, R. B. Logan-Sinclair, and P. J. Barnes. 1995. Elevated levels of exhaled nitric oxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 151:1889-1893.
9. Tracey, W. R., C. Xue, V. Klinghofer, J. Barlow, J. S. Pollock, U. Fostermann, and R. A. Johns. 1994. Immunochemical detection of inducible NO synthase in human lung. Am. J. Physiol. 266:L722-L727.
10. Nagaki, M., M. N. Shimura, T. Irokawa, T. Sasaki, and K. Shirato. 1995. Nitric oxide regulation of glycoconjugate secretion from feline and human airways in vitro. Respir. Physiol. 102:89-95.
11. Jain, B., I. Rubinstein, R. A. Robbins, K. L. Leisc, and J. H. Sisson. 1993. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem. Biophys. Res. Commun. 191:83-88.
12. Brown, J. F., A. C. Keates, P. J. Hanson, and B. J. Whittle. 1993. Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. Am. J. Physiol. 265:G418-G422.
13. Branka, J.-E., G. Vallette, A. Jarry, and C. L. Laboisse. 1997. Stimulation of mucin exocytosis from human epithelial cells by nitric oxide: evidence for a cGMP-dependent and a cGMP-independent pathway. Biochem. J. 323: 521-524.
14. Geary, C. A., C. W. Davis, A. M. Paradiso, and R. C. Boucher. 1995. Role of CNP in human airways: cGMP-mediated stimulation of ciliary beat frequency. Am. J. Physiol. 268:1.1021-L1028.
15. Lincoln, T. M., and T. L. Cornwell. 1993. Intracellular cyclic GMP receptor proteins. FASEB J. 7:328-338.
16. Adler, K. B., P. W. Cheng, and K. C. Kim. 1990. Characterization of guinea pig tracheal epithelial cells maintained in biphasic organotypic culture: cellular composition and biochemical analysis of released glycoconjugates. Am. J. Respir. Cell Mol. Biol. 2:145-154.
17. Beavo, J. A., N. L. Rogers, O. B. Crofford, J. G. Hardman, E. W. Sutherland, and E. V. Newman. 1970. Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol. Pharmacol. 6:597-603.
18. Wright, D. T., B. M. Fischer, C. Li, L. G. Rochelle, N. J. Akley, and K. B. Adler. 1996. Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. Am. J. Physiol. 271: L854-L861.
19. Kobayashi, E., H. Nakano, M. Morimoto, and T. Tamaoki. 1989. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553.
20. Cox, R. D. 1980. Determination of nitrate and nitrite at the parts per billion level by chemilumincscence. Anal. Chem. 52:332-335.
21. Kleinbaum, D. G., L. L. Kupper, and K. E. Muller. 1988. Applied Regression Analysis and Multivariate Methods. PSW-Kent, Boston, MA.
22. Kawada, T., T. Ishibashi, H. Sasage, K. Kato, and S. Imai. 1994. Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glycerol trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit. Gen. Pharmacol. 25:1361-1371.
23. Grider, J. R. 1993. Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am. J. Physiol. 264:G334-G340.
24. Schutze, S., K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Kronke. 1992. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:765-776.
25. Davis, P. D., L. H. Elliott, W. Harris, C. H. Hill, S. A. Hurst, E. Keech, M. K. Kumar, G. Lawton, J. S. Nixon, and S. E. Wilkonson. 1992. Inhibitors of protein kinase C: 2. Substituted bisindolylmaleimides with improved potency and selectivity. J. Med. Chem. 35:994-1001.
26. Nettesheim, P., and T. Bader. 1996. Tumor necrosis factor alpha stimulates arachidonic acid metabolism and mucus production in rat tracheal epithelial cell cultures. Toxicol. Lett. 88:35-37.
27. Cembrzynska-Nowak, M., E. Szklarz, A. D. Inglot, and J. A. Teodorczyk-Injeyan. 1993. Elevated release of tumor necrosis factor-α and interferon-γ by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis. 147:291-295.
28. Krunkosky, T. M., B. M. Fischer, J. R. Dodam, and K. B. Adler. 1998. Mechanisms of TNF-α signaling in airway epithelial cells in vitro. Am. J. Respir. Crit Care Med. 157:A198. (Abstr.)
29. Bader, T., and P. Nettesheim. 1996. Tumor necrosis factor-alpha modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells. J. Immunol. 157:3089-3096.
30. Olsson, I., T. Gatanaga, U. Gullberg, M. Lantz, and G. A. Granger. 1993. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. Eur. Cytokine Netw. 4:169-180.
31. Schutze, S., D. Berkovic. O. Tomsing, C. Unger, and M. Kronke. 1991. Tumor necrosis factor induces rapid production of 1′2′diacylglycerol by a phosphatidylcholine-spccific phospholipase C. J. Exp. Med. 174:975-988.
32. Rapuano, B. E., and R. S. Bockman. 1991. Tumor necrosis factor-alpha stimulates phosphalidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line. Biochim. Biophys. Acta 1091:374-384.
33. Li, H., N. H. Choe, D. T. Wright, and K. B. Adler. 1995. Histamine provokes turnover of inositol phospholipids in guinea pig and human airway epithelial cells via an H1-receptor/G protein-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 12:416-424.
34. Kim, K. C., Q.-X. Zheng, and I. Van-Seuningen. 1993. Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells. Am. J. Respir. Cell Mol. Biol. 8:121-125.
35. Halstead, J., K. Kemp, and R. Ignotz. 1995. Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-beta signaling. J. Biol. Chem. 270:13600-13603.
36. Reynolds, N. J., H. S. Talwar, J. J. Baldassare, P. A. Henderson, J. T. Elder, J. J. Voorhees, and G. J. Fisher. 1993. Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes. Biochem. J. 294:535-544. [Published erratum appears in Biochem. J. 295:903.]
37. Sands, W. A., J. S. Clark, and F. Y. Liew. 1994. The role of a phosphatidylcholine-specific phospholipase C in the production of diacylglycerol for nitric oxide synthesis in macrophages activated by IFN-gamma and LPS. Biochem. Biophys. Res. Commun. 199:461-466.
38. Spurzem, J. R., H. Ito, T. A. Wyatt, S. Emanuel, and T. Veys. 1996. Tumor necrosis factor-α (TNF-α) modulates bronchial epithelial cell migration through activation of protein kinase C (PKC). Am. J. Respir. Crit. Care Med. 153:A238. (Abstr.)
39. Serfilippi, G., T. J. Ferro, and A. Johnson. 1994. Activation of protein kinase C mediates altered pulmonary vasoreactivity induced by tumor necrosis factor-alpha. Am. J. Physiol. 267:L282-L290.
40. Ferro, T. J., D. M. Parker, L. M. Commins, P. G. Phillips, and A. Johnson. 1993. Tumor necrosis factor-alpha activates pulmonary artery endothelial protein kinase C. Am. J. Physiol. 264:L7-L14.
41. Twomey, B., R. E. Muid, J. S. Nixon, A. D. Sedgwick, S. E. Wilkinson, and M. M. Dale. 1990. The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst. Biochem. Biophys. Res. Commun. 171:1087-1092.
42. Krunkosky, T. M., L. D. Martin, B. M. Fischer, and K B. Adler. 1997. Mechanisms of TNF-alpha-induced ICAM-1 expression in airway epithelium. Am. J. Respir. Crit. Care Med. 155:A207. (Abstr.)
43. Rieves, R. D., J. D. Lundgren, C. Logun, T. Wu, and J. H. Shelhamer. 1991. Effect of protein kinase C activating agents on respiratory glycoconjugate release from feline airways. Am. J. Physiol. 261:L415-L423.
44. Ko, K. O., M. Jo, K. McCracken, and K. C. Kim. 1997. ATP-induced mucin release from cultured airway goblet cells involves, in part, activation of protein kinase C. Am. J. Respir. Cell Mol. Biol. 16:194-198.
45. +2 activation of mucin secretion in airway goblet cells. Am. J. Physiol. 273:L201-L210.
46. Severn, A., M. J. Wakelam, and F. Y. Liew. 1992. The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages, Biochem. Biophys. Res. Commun. 188:997-1002.
47. Nakane, M., J. Mitchell, U. Forstermann, and F. Murad. 1991. Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. Biochem. Biophys. Res. Commun. 180:1396-1406.
48. Sands, W. A., V. Bulut, A. Severn, D. Xu, and F. Y. Liew. 1994. Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon. Eur. J. Immunol. 24:2345-2350.
49. Diaz-Guerra, M. J., O. G. Bodelon, M. Velasco, R. Whelan, P. J. Parker, and E. Bosca. 1996. Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells. J. Biol. Chem. 271:32028-32033.
50. Robbins, R. A., J. H. Sisson, D. R. Springall, K. J. Nelson, J. A. Taylor, N. A. Mason, J. M. Polak, and R. G. Townley. 1997. Human lung mononuclear cells induce nitric oxide synthase in murine airway epithelial cells in vitro: role of TNF-α and IL-1β. Am. J. Respir. Crit. Care Med. 155: 268-273.
51. Wyatt, T. A., T. M. Lincoln, and K. B. Pryzwansky. 1993. Regulation of human neutrophil degranulation by LY-83583 and L-arginine: role of cGMP-dependent protein kinase. Am. J. Physiol. 265:C201-C211.
52. Van Epps-Fung, C., J. P. Williams, T. L. Cornwell, T. M. Lincoln, J. M. McDonald, W. Radding, and H. C. Blair. 1994. Regulation of osteoclastic acid secretion by cGMP-dependent protein kinase. Biochem. Biophys. Res. Commun. 204:565-571.
53. French, P., J. Bijman, M. Edixhoven, A. B. Vaandrager, J. B. Scholte, S. M. Lohmann, A. C. Nairn, and H. R. de Jonge. 1995. Isotype-spccific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II. J. Biol. Chem. 270:26626-26631.