Salivary hormone measurement using LC/MS/MS: Specific and patient-friendly tool for assessment of endocrine function

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 9, 2012, Pages 1401-1408

  Higashi, Tatsuya ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Derivatization; Endocrine function; Hormone; LC MS MS; Saliva

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; ADRENALIN; BILE ACID; CALCIFEDIOL; CHENODEOXYCHOLIC ACID; CORTISONE; FLUDROCORTISONE; GLUCOCORTICOID; HOMOVANILLIC ACID; HORMONE; HYDROCORTISONE; HYDROXYPROGESTERONE; MELATONIN; MINERALOCORTICOID; NORADRENALIN; PRASTERONE; PRASTERONE SULFATE; STEROID HORMONE; TESTOSTERONE; THYROXINE;

ARTICLE; CONGENITAL ADRENAL HYPERPLASIA; ELECTROSPRAY MASS SPECTROMETRY; ENDOCRINE FUNCTION TEST; HORMONE DETERMINATION; HORMONE SUBSTITUTION; HORMONE TRANSPORT; HUMAN; HYPOGONADISM; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; SALIVA; SALIVA ANALYSIS; SENSITIVITY AND SPECIFICITY;

EID: 84866039651     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b212009     Document Type: Article

References (48)

1. Pitt JJ. Principles and applications of liquid chromatography-mass spectrometry in clinical biochemistry. Clin. Biochem. Rev., 30, 19-34 (2009).
2. Kushnir MM, Rockwood AL, Bergquist J. Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrom. Rev., 29, 480-502 (2010).
3. Kushnir MM, Rockwood AL, Roberts WL, Yue B, Bergquist J, Meikle AW. Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories. Clin. Biochem., 44, 77-88 (2011).
4. Vining RF, McGinley RA. The measurement of hormones in saliva: possibilities and pitfalls. J. Steroid Biochem., 27, 81-94 (1987).
5. Chiappin S, Antonelli G, Gatti R, De Palo EF. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin. Chim. Acta, 383, 30-40 (2007).
6. Gröschl M. Current status of salivary hormone analysis. Clin. Chem., 54, 1759-1769 (2008).
7. Higashi T, Shimada K. Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry. Anal. Bioanal. Chem., 378, 875-882 (2004).
8. Santa T. Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry. Biomed. Chromatogr., 25, 1-10 (2011).
9. Xu F, Zou L, Liu Y, Zhang Z, Ong CN. Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications. Mass Spectrom. Rev., 30, 1143-1172 (2011).
10. Schwartz EB, Granger DA. Transferrin enzyme immunoassay for quantitative monitoring of blood contamination in saliva. Clin. Chem., 50, 654-656 (2004).
11. Gröschl M, Rauh M. Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids, 71, 1097-1100 (2006).
12. Gröschl M, Köhler H, Topf HG, Rupprecht T, Rauh M. Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J. Pharm. Biomed. Anal., 47, 478-486 (2008).
13. Atkinson KR, Lo KR, Payne SR, Mitchell JS, Ingram JR. Rapid saliva processing techniques for near real-time analysis of salivary steroids and protein. J. Clin. Lab. Anal., 22, 395-402 (2008).
14. Mylonas PG, Makri M, Georgopoulos NA, Theodoropoulou A, Leglise M, Vagenakis AG, Markou KB. Adequacy of saliva 17-hydroxyprogesterone determination using various collection methods. Steroids, 71, 273-276 (2006).
15. Higashi T, Shibayama Y, Shimada K. Determination of salivary dehydroepiandrosterone using liquid chromatography-tandem mass spectrometry combined with charged derivatization. J. Chromatogr. B, 846, 195-201 (2007).
16. Higashi T, Shibayama Y, Ichikawa T, Ito K, Toyo'oka T, Shimada K, Mitamura K, Ikegawa S, Chiba H. Salivary chenodeoxycholic acid and its glycine-conjugate: their determination method using LC/MS/MS and variation of their concentrations with increased saliva flow rate. Steroids, 75, 338-345 (2010).
17. Popa M, Simionescu L, Dumitriu E, Dimitriu V, Giurcãneanu M, Bartoc R, Dinulescu E. Serum-to-saliva transfer of the immunoreactive insulin (IRI) in children with obesity associated with insulin-resistance. Endocrinologie, 25, 149-155 (1987).
18. Griffiths WJ. Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids. Mass Spectrom. Rev., 22, 81-152 (2003).
19. Higashi T, Ito K, Narushima M, Sugiura T, Inagaki S, Min JZ, Toyo'oka T. Development and validation of stable-isotope dilution liquid chromatography-tandem mass spectrometric method for determination of salivary progesterone. Biomed. Chromatogr., 25, 1175-1180 (2011).
20. Higashi T. Trace determination of steroids causing age-related diseases using LC/MS combined with detection-oriented derivatization. Chem. Pharm. Bull., 54, 1479-1485 (2006).
21. Yamashita K, Okuyama M, Nakagawa R, Honma S, Satoh F, Morimoto R, Ito S, Takahashi M, Numazawa M. Development of sensitive derivatization method for aldosterone in liquid chromatography-electrospray ionization tandem mass spectrometry of corticosteroids. J. Chromatogr. A, 1200, 114-121 (2008).
22. Arai S, Miyashiro Y, Shibata Y, Kashiwagi B, Tomaru Y, Kobayashi M, Watanabe Y, Honma S, Suzuki K. New quantification method for estradiol in the prostatic tissues of benign prostatic hyperplasia using liquid chromatography-tandem mass spectrometry. Steroids, 75, 13-19 (2010).
23. Jönsson BAG, Malmberg B, Amilon Å, Helene Garde A, Ørbaek P. Determination of cortisol in human saliva using liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B, 784, 63-68 (2003).
24. Turpeinen U, Välimäki MJ, Hämäläinen E. Determination of salivary cortisol by liquid chromatography-tandem mass spectrometry. Scand. J. Clin. Lab. Invest., 69, 592-597 (2009).
25. Perogamvros I, Owen LJ, Newell-Price J, Ray DW, Trainer PJ, Keevil BG. Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions. J. Chromatogr. B, 877, 3771-3775 (2009).
26. Owen LJ, Haslam S, Adaway JE, Wood P, Glenn C, Keevil BG. A simplified liquid chromatography tandem mass spectrometry assay, using on-line solid-phase extraction, for the quantitation of cortisol in saliva and comparison with a routine DELFIA method. Ann. Clin. Biochem., 47, 131-136 (2010).
27. McWhinney BC, Briscoe SE, Ungerer JP, Pretorius CJ. Measurement of cortisol, cortisone, prednisolone, dexamethasone and 11-deoxycortisol with ultra high performance liquid chromatography-tandem mass spectrometry: Application for plasma, plasma ultrafiltrate, urine and saliva in a routine laboratory. J. Chromatogr. B, 878, 2863-2869 (2010).
28. Lee S, Kwon S, Shin HJ, Lim HS, Singh RJ, Lee KR, Kim YJ. Simultaneous quantitative analysis of salivary cortisol and cortisone in Korean adults using LC/MS/MS. BMB Rep., 43, 506-511 (2010).
29. Smith RE, Maguire JA, Stein-Oakley AN, Sasano H, Takahashi K, Fukushima K, Krozowski ZS. Localization of 11β-hydroxysteroid dehydrogenase type II in human epithelial tissues. J. Clin. Endocrinol. Metab., 81, 3244-3248 (1996).
30. Perogamvros I, Keevil BG, Ray DW, Trainer PJ. Salivary cortisone is a potential biomarker for serum free cortisol. J. Clin. Endocrinol. Metab., 95, 4951-4958 (2010).
31. Witchel SF, Azziz R. Congenital adrenal hyperplasia. J. Pediatr. Adolesc. Gynecol., 24, 116-126 (2011).
32. Shibayama Y, Higashi T, Shimada K, Kashimada K, Onishi T, Ono M, Miyai K, Mizutani S. Liquid chromatography-tandem mass spectrometric method for determination of salivary 17α-hydroxyprogesterone: a noninvasive tool for evaluating efficacy of hormone replacement therapy in congenital adrenal hyperplasia. J. Chromatogr. B, 867, 49-56 (2008).
33. Higashi T, Nishio T, Hayashi N, Shimada K. Alternative procedure for charged derivatization to enhance detection responses of steroids in electrospray ionization-MS. Chem. Pharm. Bull., 55, 662-665 (2007).
34. Yasuda M, Honma S, Furuya K, Yoshii T, Kamiyama Y, Ide H, Muto S, Horie S. Diagnostic significance of salivary testosterone measurement revisited: using liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay. J. Men's Health, 5, 56-63 (2008).
35. Shibayama Y, Higashi T, Shimada K, Odani A, Mizokami A, Konaka H, Koh E, Namiki M. Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC/MS/MS: Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism. J. Chromatogr. B, 877, 2615-2623 (2009).
36. Matsui F, Koh E, Yamamoto K, Sugimoto K, Sin HS, Maeda Y, Honma S, Namiki M. Liquid chromatography-tandem mass spectrometry (LC/MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males. Endocr. J., 56, 1083-1093 (2009).
37. Nieschlag E, Swerdloff R, Behre HM, Gooren LJ, Kaufman JM, Legros J-J, Lunenfeld B, Morley JE, Schulman C, Wang C, Weidner W, Wu FCW. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J. Androl., 27, 135-137 (2006).
38. Arlt W. Dehydroepiandrosterone and ageing. Best Pract. Res. Clin. Endocrinol. Metab., 18, 363-380 (2004).
39. Higashi T, Yamauchi A, Shimada K. 2-Hydrazino-1-methylpyridine: a highly sensitive derivatization reagent for oxosteroids in liquid chromatography- electrospray ionization-mass spectrometry. J. Chromatogr. B, 825, 214-222 (2005).
40. Higashi T, Shimada K, Toyo'oka T. Advances in determination of vitamin D related compounds in biological samples using liquid chromatography-mass spectrometry: a review. J. Chromatogr. B, 878, 1654-1661 (2010).
41. Higashi T, Shibayama Y, Fuji M, Shimada K. Liquid chromatography-tandem mass spectrometric method for the determination of salivary 25-hydroxyvitamin D3: a noninvasive tool for the assessment of vitamin D status. Anal. Bioanal. Chem., 391, 229-238 (2008).
42. Kennedy B, Dillon E, Mills PJ, Ziegler MG. Catecholamines in human saliva. Life Sci., 69, 87-99 (2001).
43. Drebing CJ, Freedman R, Waldo M, Gerhardt GA. Unconjugated methoxylated catecholamine metabolites in human saliva. Quantitation methodology and comparison with plasma levels. Biomed. Chromatogr., 3, 217-220 (1989).
44. Yang RK, Yehuda R, Holland DD, Knott PJ. Relationship between 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in saliva and plasma of healthy volunteers. Biol. Psychiatry, 42, 821-826 (1997).
45. Higashi T, Ichikawa T, Inagaki S, Min JZ, Fukushima T, Toyo'oka T. Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal., 52, 809-818 (2010).
46. Jensen MA, Hansen AM, Abrahamsson P, Nørgaard AW. Development and evaluation of a liquid chromatography tandem mass spectrometry method for simultaneous determination of salivary melatonin, cortisol and testosterone. J. Chromatogr. B, 879, 2527-2532 (2011).
47. Schussler GC. The thyroxine-binding proteins. Thyroid, 10, 141-149 (2000).
48. Higashi T, Ichikawa T, Shimizu C, Nagai S, Inagaki S, Min JZ, Chiba H, Ikegawa S, Toyo'oka T. Stable isotope-dilution liquid chromatography/tandem mass spectrometry method for determination of thyroxine in saliva. J. Chromatogr. B, 879, 1013-1017 (2011).