Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS: Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 25, 2009, Pages 2615-2623

  Shibayama, Yujin ^a   Higashi, Tatsuya ^a   Shimada, Kazutake ^a   Odani, Akira ^a   Mizokami, Atsushi ^a   Konaka, Hiroyuki ^a   Koh, Eitetsu ^a   Namiki, Mikio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Dehydroepiandrosterone; Late onset hypogonadism; Liquid chromatography electrospray ionization tandem mass spectrometry; Saliva; Simultaneous quantification; Testosterone

Indexed keywords

DEHYDROEPIANDROSTERONE; LATE-ONSET HYPOGONADISM; SALIVA; SIMULTANEOUS QUANTIFICATION; TESTOSTERONE;

ACETONITRILE; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DEUTERIUM; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY;

ELECTROSPRAY IONIZATION;

2 HYDRAZINO 1 METHYLPYRIDINE; ACETONITRILE; ANDROGEN; PRASTERONE; PYRIDINE DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; ARTICLE; CALIBRATION; CHEMICAL STRUCTURE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION RESEARCH; HUMAN; HUMAN EXPERIMENT; HYPOGONADISM; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SALIVA ANALYSIS; SENSITIVITY AND SPECIFICITY;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, LIQUID; DEHYDROEPIANDROSTERONE; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; SALIVA; TANDEM MASS SPECTROMETRY; TESTOSTERONE; YOUNG ADULT;

EID: 67651183951     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.10.051     Document Type: Article

References (21)

1. Nieschlag E., Swerdloff R., Behre H.M., Gooren L.J., Kaufman J.M., Legros J.-J., Lunenfeld B., Morley J.E., Schulman C., Wang C., Weidner W., and Wu F.C.W. J. Androl. 27 (2006) 135
2. Dunn J.F., Nisula B.C., and Rodbard D. J. Clin. Endocrinol. Metab. 53 (1981) 58
3. Harman S.M., Metter E.J., Tobin J.D., Pearson J., and Blackman M.R. J. Clin. Endocrinol. Metab. 86 (2001) 724
4. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., Bremner W.J., and McKinlay J.B. J. Clin. Endocrinol. Metab. 87 (2002) 589
5. Iwamoto T., Yanase T., Koh E., Horie H., Baba K., Namiki M., and Nawata H. Nippon Hinyokika Gakkai Zasshi 95 (2004) 751
6. Morley J.E., Perry III H.M., Patrick P., Dollbaum C.M., and Kells J.M. Aging Male 9 (2006) 165
7. Arregger A.L., Contreras L.N., Tumilasci O.R., Aquilano D.R., and Cardoso E.M.L. Clin. Endocrinol. 67 (2007) 656
8. Yasuda M., Honma S., Furuya K., Yoshii T., Kamiyama Y., Ide H., Muto S., and Horie S. J. Men's Health 5 (2008) 56
9. Arlt W. Best Pract. Res. Clin. Endocrinol. Metab. 18 (2004) 363
10. Granger D.A., Schwartz E.B., Booth A., Curran M., and Zakaria D. Psychoneuroendocrinology 24 (1999) 567
11. Ahn R.-S., Lee Y.-J., Choi J.-Y., Kwon H.-B., and Chun S.-I. Yonsei Med. J. 48 (2007) 379
12. Lewis J.G. Clin. Biochem. Rev. 27 (2006) 139
13. Rey F., Chiodoni G., Braillard K., Berthod C., and Lemarchand-Béraud T. Clin. Chim. Acta 191 (1990) 21
14. Griffiths W.J. Mass Spectrom. Rev. 22 (2003) 81
15. Higashi T., Yamauchi A., and Shimada K. J. Chromatogr. B 825 (2005) 214
16. Higashi T., Shibayama Y., and Shimada K. J. Chromatogr. B 846 (2007) 195
17. Baba S., Shinohara Y., and Kasuya Y. J. Labeled Compd. Radiopharm. 14 (1978) 783
18. Mitamura K., Nakagawa T., Shimada K., Namiki M., Koh E., Mizokami A., and Honma S. J. Chromatogr. A 961 (2002) 97
19. Choo R.E., and Huestis M.A. Clin. Chem. Lab. Med. 42 (2004) 1273
20. Gröschl M., Köhler H., Topf H.-G., Rupprecht T., and Rauh M. J. Pharm. Biomed. Anal. 47 (2008) 478
21. Namiki M., Akaza H., Shimazui T., Ito N., Iwamoto T., Baba K., Kumano H., Koh E., Tsujimura A., Matsumiya K., Horie S., Maruyama O., Marumo K., Yamase T., and Kumamoto Y. Int. J. Urol. 15 (2008) 377