Salivary cortisone is a potential biomarker for serum free cortisol

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 11, 2010, Pages 4951-4958

  Perogamvros, I ^a   Keevil, B G ^b   Ray, D W ^a   Trainer, Peter J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTISONE; HYDROCORTISONE; TETRACOSACTIDE; TRANSCORTIN;

ADRENAL GLAND; ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HORMONAL CONTRACEPTION; HORMONE ACTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; IMMUNOASSAY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SALIVARY GLAND;

EID: 78049500486     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1215     Document Type: Article

References (31)

1. Mendel CM 1989 The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10:232-274
2. Lewis JG, Bagley CJ, Elder PA, Bachmann AW, Torpy DJ 2005 Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin. Clin Chim Acta 359:189-194
3. Hammond GL, Smith CL, Underhill DA 1991 Molecular studies of corticosteroid binding globulin structure, biosynthesis and function. J Steroid Biochem Mol Biol 40:755-762
4. Coolens JL, Van Baelen H, Heyns W 1987 Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem 26:197-202 (Pubitemid 17040122)
5. Vogeser M, Briegel J, Zachoval R 2002 Dialyzable free cortisol after stimulation with Synacthen. Clin Biochem 35:539-543
6. Pugeat M, Bonneton A, Perrot D, Rocle-Nicolas B, Lejeune H, Grenot C, Déchaud H, Brébant C, Motin J, Cuilleron CY 1989 Decreased immunoreactivity and binding activity of corticosteroidbinding globulin in serum in septic shock. Clin Chem 35:1675-1679
7. Hamrahian AH, Oseni TS, Arafah BM 2004 Measurements of serum free cortisol in critically ill patients. N Engl J Med 350:1629-1638 (Pubitemid 38501164)
8. Arafah BM 2006 Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods. J Clin Endocrinol Metab 91:3725-3745
9. Loriaux L 2004 Glucocorticoid therapy in the intensive care unit. N Engl J Med 350:1601-1602
10. Ho JT, Al-Musalhi H, Chapman MJ, Quach T, Thomas PD, Bagley CJ, Lewis JG, Torpy DJ 2006 Septic shock and sepsis: a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 91:105-114
11. Hellhammer DH, Wüst S, Kudielka BM 2009 Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology 34:163-171
12. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM 2008 The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93:1526-1540
13. Perogamvros I, Owen LJ, Keevil BG, Brabant G, Trainer PJ 2010 Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing. Clin Endocrinol (Oxf) 72:17-21
14. Arafah BM, Nishiyama FJ, Tlaygeh H, Hejal R 2007 Measurement of salivary cortisol concentration in the assessment of adrenal function in critically ill subjects: a surrogate marker of the circulating free cortisol. J Clin Endocrinol Metab 92:2965-2971
15. Thomson AH, Devers MC, Wallace AM, Grant D, Campbell K, Freel M, Connell JM 2007 Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clin Endocrinol (Oxf) 66:789-796
16. Wong V, Yan T, Donald A, McLean M 2004 Saliva and bloodspot cortisol: novel sampling methods to assess hydrocortisone replacement therapy in hypoadrenal patients. Clin Endocrinol (Oxf) 61:131-137 (Pubitemid 38951656)
17. Vining RF, McGinley RA, Maksvytis JJ, Ho KY 1983 Salivary cortisol: a better measure of adrenal cortical function than serum cortisol. Ann Clin Biochem 20(Pt 6):329-335
18. Smith RE, Maguire JA, Stein-Oakley AN, Sasano H, Takahashi K, Fukushima K, Krozowski ZS 1996 Localization of 11β-hydroxysteroid dehydrogenase type II in human epithelial tissues. J Clin Endocrinol Metab 81:3244-3248
19. Perogamvros I, Owen LJ, Newell-Price J, Ray DW, Trainer PJ, Keevil BG 2009 Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions. J Chromatogr B Analyt Technol Biomed Life Sci 877:3771-3775
20. Perogamvros I, Underhill C, Henley DE, Hadfield KD, Newman WG, Ray DW, Lightman SL, Hammond GL, Trainer PJ 2010 Novel corticosteroid-binding globulin variant that lacks steroid binding activity. J Clin Endocrinol Metab 95:E142-E150
21. Hammond GL, Langley MS 1986 Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva. Acta Endocrinol (Copenh) 112:603-608
22. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troché G, Chaumet-Riffaud P, Bellissant E 2002 Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871
23. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M 2008 Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36:1937-1949
24. Hammond GL, Smith CL, Paterson NA, Sibbald WJ 1990 A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. J Clin Endocrinol Metab 71:34-39
25. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y 2004 Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev CD002243
26. Klose M, Lange M, Rasmussen AK, Skakkebaek NE, Hilsted L, Haug E, Andersen M, Feldt-Rasmussen U 2007 Factors influencing the adrenocorticotropin test: role of contemporary cortisol assays, body composition, and oral contraceptive agents. J Clin Endocrinol Metab 92:1326-1333
27. Roberts RF, Roberts WL 2004 Performance characteristics of five automated serum cortisol immunoassays. Clin Biochem 37:489-493
28. 2008 Advia Centaur immunoassay systems customer bulletin. Surrey, UK: Siemens Healthcare Diagnostics Ltd.
29. van Uum SH, Walker BR, Hermus AR, Sweep CG, Smits P, de Leeuw PW, Lenders JW 2002 Effect of glycyrrhetinic acid on 11β-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects. Clin Sci (Lond) 102:203-211
30. Quinkler M, Stewart PM 2003 Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88:2384-2392
31. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR 1987 Mineralocorticoid activity of liquorice: 11-β-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 2:821-824