The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model

Microsurgery

Volumn 32, Issue 6, 2012, Pages 475-481

  Shafighi, Maziar ^a   Olariu, Radu ^a   Brun, Claudio ^a   Fathi, Ali R ^b   Djafarzadeh, Siamak ^a   Jakob, Stephan M ^a   Hunger, Robert E ^a   Banic, Andrej ^a   Constantinescu, Mihai A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT PERFUSION; HUMAN; IMMUNOHISTOCHEMISTRY; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; SKIN FLAP SURVIVAL; UMBILICAL VEIN ENDOTHELIAL CELL; WISTAR RAT;

ANDROGENS; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELLS, CULTURED; DIHYDROTESTOSTERONE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LASER-DOPPLER FLOWMETRY; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; ORCHIECTOMY; RATS; RATS, WISTAR; SURGICAL FLAPS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84866028481     PISSN: 07381085     EISSN: 10982752     Source Type: Journal    
DOI: 10.1002/micr.21996     Document Type: Article

References (41)

1. Emery Shalom A, Friedman T, Westreich M,. The effect of postoperative aspirin on random pattern flaps in rats. Am Surg 2007; 73: 1126-1128.
2. Emery FM, Kodey TR, Bomberger RA, McGregor DB,. The effect of nifedipine on skin flap survival. Plast Reconstr Surg 1990; 85: 61-63.
3. Miyawaki T, Jackson IT, Elmazar H, Bier UC, Barakat K, Andrus L, Williams F,. The effect of capsaicin ointment on skin for the survival of a cutaneous flap. Eur J Plast Surg 2001; 24: 28-30.
4. Huemer GM, Wechselberger G, Otto-Schoeller A, Gurunluoglu R, Piza-Katzer H, Schoeller T,. Improved dorsal random-pattern skin flap survival in rats with a topically applied combination of nonivamide and nicoboxil. Plast Reconstr Surg 2003; 111: 1207-1211.
5. Karacaoglan N, Akbas H,. Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival. Otolaryngol Head Neck Surg 1999; 120: 272-274.
6. Carmeliet P,. Angiogenesis in health and disease. Nat Med 2003; 9: 653-660.
7. Park SY, Jang WJ, Yi EY, Jang JY, Jung Y, Jeong JW, Kim YJ,. Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia. J Pineal Res 2010; 48: 178-184.
8. Arnal JF, Fontaine C, Billon-Galés A, Favre J, Laurell H, Lenfant F, Gourdy P,. Estrogen receptors and endothelium. Arterioscler Thromb Vasc Biol 2010; 30: 1506-1512.
9. Gurlek A, Aydogan H, Parlakpinar H, Bay-Karabulut A, Celik M, Sezgin N, Acet A,. Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat. J Pineal Res 2004; 6: 58-63.
10. Toutain CE, Brouchet L, Raymond-Letron I, Vicendo P, Bergès H, Favre J, Fouque MJ, Krust A, Schmitt AM, Chambon P, Gourdy P, Arnal JF, Lenfant F,. Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network. Circ Res 2009; 104: 245-254.
11. Colombel M, Filleur S, Fournier P, Merle C, Guglielmi J, Courtin A, Degeorges A, Serre CM, Bouvier R, Clézardin P, Cabon F,. Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate. Cancer Res 2005; 65: 300-308.
12. Sordello S, Bertrand N, Plouët J,. Vascular endothelial growth factor is up-regulated in vitro and in vivo by androgens. Biochem Biophys Res Commun 1998; 251: 287-290.
13. Singh R, Pervin S, Shryne J, Gorski R, Chaudhuri G,. Castration increases and androgens decrease nitric oxide synthase activity in the brain: Physiologic implications. Proc Natl Acad Sci USA 2000; 97: 3672-3677.
14. Engeland CG, Sabzehei B, Marucha PT,. Sex hormones and mucosal wound healing. Brain Behav Immun 2009; 23: 629-635.
15. Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW,. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res 2003; 9: 2416-2425.
16. 2 sensing. Science 2001; 292: 464-468.
17. Ferrara N,. Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev 2004; 25: 581-611.
18. Forsythe JA, Jiang B-H, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL,. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16: 4604-4613.
19. Sieveking DP, Lim P, Chow RW, Dunn LL, Bao S, McGrath KC, Heather AK, Handelsman DJ, Celermajer DS, Ng MK,. A sex-specific role for androgens in angiogenesis. J Exp Med 2010; 207: 345-352.
20. Schofield CJ, Ratcliffe PJ,. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004; 5: 343-354.
21. Shibata Y, Ito K, Suzuki K, Nakano K, Fukabori Y, Suzuki R, Kawabe Y, Honma S, Yamanaka H,. Changes in the endocrine environment of the human prostate transition zone with aging: Simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate 2000; 42: 45-55.
22. McFarlane RM, DeYoung G, Henry RA,. The design of a pedicle flap in the rat to study necrosis and its prevention. Plast Reconstr Surg 1965; 35: 177-182.
23. Rinsch C, Quinodoz P, Pittet B, Alizadeh N, Baetens D, Montandon D, Aebischer P, Pepper MS,. Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia. Gene Ther 2001; 8: 523-533.
24. Schlapbach C, Yawalkar N, Hunger RE,. Human β-defensin-2 and psoriasin are overexpressed in lesions of acne inversa. J Am Acad Dermatol 2009; 61: 58-65.
25. Kapcińska B, Jagsz S, Sadowska-Krepa E, Gõrski J, Kempa K, Langfort J,. Effects of castration and testosterone replacement on the antioxidant defense system in rat left ventricle. J Physiol Sci 2008; 58: 173-177.
26. Henderson PW, Singh SP, Belkin D, Nagineni V, Weinstein AL, Weissich J, Spector JA,. Hydrogen sulfide protects against ischemia-reperfusion injury in an in vitro model of cutaneous tissue transplantation. J Surg Res 2010; 159: 451-455.
27. Shafighi M, Olariu R, Fathi AR, Djafarzadeh S, Jakob SM, Banic A, Constantinescu MA,. Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo. Plast Reconstr Surg 2011; 128: 415-422.
28. Semenza GL,. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001; 7: 345-350.
29. Gurunluoglu R, Meirer R, Shafighi M, Huemer GM, Yilmaz B, Piza-Katzer H,. Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication. Microsurgery 2005; 25: 433-441.
30. Huemer GM, Shafighi M, Meirer R, Debagge P, Piza-Katzer H, Gurunluoglu R,. Adenovirus-mediated transforming growth factor-β ameliorates ischemic necrosis of epigastric skin flaps in a rat model. J Surg Res 2004; 121: 101-107.
31. Patak P, Jin F, Schäfer ST, Metzen E, Hermann DM,. The ATP-binding cassette transporters ABCB1 and ABCC1 are not regulated by hypoxia in immortalised human brain microvascular endothelial cells. Exp Transl Stroke Med 2011; 3: 12-18.
32. Stiehl DP, Wirthner R, Köditz J, Spielmann P, Camenisch G, Wenger RH,. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J Biol Chem 2006; 281: 23482-23491.
33. Stroka DM, Burkhardt T, Desbaillets I, Wenger RH, Neil DA, Bauer C, Gassmann M, Candinas D,. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 2001; 15: 2445-2453.
34. Wu FC, von Eckardstein A,. Androgens and coronary artery disease. Endocr Rev 2003; 24: 183-217.
35. Wingard DL, Suarez L, Barrett-Connor E,. The sex differential in mortality from all causes and ischemic heart disease. Am J Epidemiol 1983; 117: 165-172.
36. Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N,. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population study. Circulation 2007; 116: 2694-2701.
37. Smith GD, Ben-Shlomo Y, Beswick A, Yamell J, Lightman S, Elwood P,. Cortisol, testosterone, and coronary heart disease: Prospective evidence from the Caerphilly study. Circulation 2005; 112: 332-340.
38. Franck-Lissbrant I, Haggstrom S, Damber JE, Bergh A,. Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology 1998; 139: 451-456.
39. Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR, Harris AL,. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res 2005; 11: 7658-7663.
40. Death AK, McGrath KC, Sader MA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS,. Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-ÎB- dependent pathway. Endocrinology 2004; 145: 1889-1897.
41. Ng MK, Quinn CM, McCrohon JA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS, Death AK,. Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: Molecular insights into gender differences in atherosclerosis. J Am Coll Cardiol 2003; 42: 1306-1313.