Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-κB-dependent pathway

Endocrinology

Volumn 145, Issue 4, 2004, Pages 1889-1897

  Death, Alison K ^a   McGrath, Kristine C Y ^a   Sader, Mark A ^b   Nakhla, Shirley ^b   Jessup, Wendy ^c   Handelsman, David J ^d   Celermajer, David S ^a,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d ANZAC RESEARCH INSTITUTE   (Australia)

^e ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; ESTROGEN; HORMONE RECEPTOR BLOCKING AGENT; HYDROXYFLUTAMIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CATTLE; CELL ADHESION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; FEMALE; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA STABILITY; SEX DIFFERENCE; UMBILICAL VEIN;

ADULT; AGED; AGED, 80 AND OVER; ANDROGENS; CELL ADHESION; CELLS, CULTURED; DIHYDROTESTOSTERONE; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOCYTES; NF-KAPPA B; PROMOTER REGIONS (GENETICS); RECEPTORS, ANDROGEN; RNA STABILITY; RNA, MESSENGER; SEX CHARACTERISTICS; TRANS-ACTIVATION (GENETICS); VASCULAR CELL ADHESION MOLECULE-1;

EID: 1642464782     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0789     Document Type: Article

References (46)

1. Kalin MF, Zumoff B 1990 Sex hormones and coronary disease: a review of the clinical studies. Steroids 55:330-352
2. Assmann G, Carmena R, Cullen P, Fruchart JC, Jossa F, Lewis B, Mancini M, Paoletti R 1999 Coronary heart disease: reducing the risk: a worldwide view. International Task Force for the Prevention of Coronary Heart Disease. Circulation 100:1930-1938
3. Mendelsohn ME, Karas RH 1999 The protective effects of estrogen on the cardiovascular system. N Engl J Med 340:1801-1811
4. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/ progestin Replacement Study (HERS) Research Group. JAMA 280:605-613
5. Simon JA, Hsia J, Cauley JA, Richards C, Harris F, Fong J, Barrett-Connor E, Hulley SB 2001 Postmenopausal hormone therapy and risk of stroke: the Heart and Estrogen-Progestin Replacement Study (HERS). Circulation 103: 638-642
6. Bhasin S, Bremner WJ 1997 Clinical review 85: emerging issues in androgen replacement therapy. J Clin Endocrinol Metab 82:3-8
7. Rockhold RW 1993 Cardiovascular toxicity of anabolic steroids. Annu Rev Pharmacol Toxicol 33:497-520
8. Sullivan ML, Martinez CM, Gennis P, Gallagher EJ 1998 The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 41:1-15
9. Liu PY, Death AK, Handelsman DJ 2003 Androgens and cardiovascular disease. Endocr Rev 24:313-340
10. Wu FC, Von Eckardstein A 2003 Androgens and coronary artery disease. Endocr Rev 24:183-217
11. Bruck B, Brehme U, Gugel N, Hanke S, Finking G, Lutz C, Benda N, Schmahl FW, Haasis R, Hanke H 1997 Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 17:2192-2199
12. Toda T, Toda Y, Cho BH, Kummerow FA 1984 Ultrastructural changes in the comb and aorta of chicks fed excess testosterone. Atherosclerosis 51:47-57
13. von Dehn G, von Dehn O, Volker W, Langer C, Weinbauer GF, Behre HM, Nieschlag E, Assmann G, von Eckardstein A 2001 Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Horm Metab Res 33:110-114
14. Adams MR, Williams JK, Kaplan JR 1995 Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness. Arterioscler Thromb Vasc Biol 15:562-570
15. Obasanjo IO, Clarkson TB, Weaver DS 1996 Effects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgus macaques. Metabolism 45:463-468
16. Elhage R, Arnal JF, Pieraggi MT, Duverger N, Fievet C, Faye JC, Bayard F 1997 17 β-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 17:2679-2684
17. Alexandersen P, Haarbo J, Byrjalsen I, Lawaetz H, Christiansen C 1999 Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circ Res 84:813-819
18. Nathan L, Shi W, Dinh H, Mukherjee TK, Wang X, Lusis AJ, Chaudhuri G 2001 Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci USA 98:3589-3593
19. Fogelberg M, Bjorkhem I, Diczfalusy U, Henriksson P 1990 Stanozolol and experimental atherosclerosis: atherosclerotic development and blood lipids during anabolic steroid therapy of New Zealand white rabbits. Scand J Clin Lab Invest 50:693-696
20. Mukherjee T, Dinh H, Chaudhuri G, Nathan L 2002 Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis. Proc Natl Acad Sci USA 99:4055-4060
21. McCredie RJ, McCrohon JA, Turner L, Griffiths KA, Handelsman DJ, Celermajer DS 1998 Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 32:1331-1335
22. Webb CM, Adamson DL, de Zeigler D, Collins P 1999 Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol 83:437-439, A9
23. Thompson PD, Ahlberg AW, Moyna NM, Duncan B, Ferraro-Borgida M, White CM, McGill CC, Heller GV 2002 Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease. Am Heart J 143: 249-256
24. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, Bonfigli B, Volpe M, Chierchia SL 1999 Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99: 1666-1670
25. Alexandersen P, Haarbo J, Christiansen C 1996 The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 125: 1-13
26. Beato M, Klug J 2000 Steroid hormone receptors: an update. Hum Reprod Update 6:225-236
27. Libby P 2001 Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104:365-372
28. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J, Cybulsky MI, Smith JD 2001 Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 21:1662-1667
29. McCrohon JA, Jessup W, Handelsman DJ, Celermajer DS 1999 Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation 99:2317-2322
30. Neish AS, Williams AJ, Palmer HJ, Whitley MZ, Collins T 1992 Functional analysis of the human vascular cell adhesion molecule 1 promoter. J Exp Med 176:1583-1593
31. Meagher L, Mahiouz D, Sugars K, Burrows N, Norris P, Yarwood H, Becker-Andre M, Haskard DO 1994 Measurement of mRNA for E-selectin, VCAM-1 and ICAM-1 by reverse transcription and the polymerase chain reaction. J Immunol Methods 175:237-246
32. Melhus H, Gobi A, Ljunghall S 1994 Competitive PCR demonstrates that 9-cis retinoic acid induces cellular retinoic acid-binding protein-II more efficiently than all-rrans retinoic acid in human osteosarcoma cells. Biochem Biophys Res Commun 200:1125-1129
33. Zhang X, Wang LY, Jiang TY, Zhang HP, Dou Y, Zhao JH, Zhao H, Qiao ZD, Qiao JT 2002 Effects of testosterone and 17-β-estradiol on TNF-α-induced E-selecrin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways. Life Sci 71:15-29
34. Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Uchida K 2002 Testosterone inhibits tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. FEBS Lett 530:129-132
35. Simoncini T, Maffei S, Basta G, Barsacchi G, Genazzani AR, Liao JK, De Caterina R 2000 Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res 87:19-25
36. Sasano H, Murakami H, Shizawa S, Satomi S, Nagura H, Harada N 1999 Aromatase and sex steroid receptors in human vena cava. Endocr J 46:233-242
37. Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F 1999 Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause 6:21-28
38. Milewich L, Kaimal V, Johnson AR 1987 Steroid 5 α-reductase activity in endothelial cells from human umbilical cord vessels. J Steroid Biochem 26: 561-567
39. McKay LI, Cidlowski JA 1998 Crosstalk between nuclear factor-κB and the steroid hormone receptor mechanisms of mutual antagonism. Mol Endocrinol 12:45-56
40. Palvimo JJ, Reinikainen P, Ikonen T, Kallio PJ, Moilanen A, Janne OA 1996 Mutual transcriptional interference between RelA and androgen receptor. J Biol Chem 271:24151-24156
41. Iiyama K, Hajra L, Iiyama M, DiChiara M, Medoff BD, Cybulsky MI 1999 Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 85:199-207
42. Holm P, Andersen HL, Arroe G, Stender S 1998 Gender gap in aortic cholesterol accumulation in cholesterol-clamped rabbits: role of the endothelium and mononuclear-endothelial cell interaction. Circulation 98:2731-2737
43. Ling S, Dai A, Williams MR, Myles K, Dilley RJ, Komesaroff PA, Sudhir K 2002 Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells. Endocrinology 143:1119-1125
44. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y, Eto S 1994 Androgen receptors, 5 α-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 50:169-174
45. Ajayi AA, Mathur R, Halushka PV 1995 Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 91:2742-2747
46. Rosenblum WI, el-Sabban F, Nelson GH, Allison TB 1987 Effects in mice of testosterone and dihydrotestosterone on platelet aggregation in injured arterioles and ex vivo. Thromb Res 45:719-728