Improved dorsal random-pattern skin flap survival in rats with a topically applied combination of nonivamide and nicoboxil

Plastic and Reconstructive Surgery

Volumn 111, Issue 3, 2003, Pages 1207-1211

  Huemer, Georg M ^a   Wechselberger, Gottfried ^a   Otto Schoeller, Angela ^a   Gurunluoglu, Raffi ^a   Piza Katzer, Hildegunde ^a   Schoeller, Thomas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FINALGON; PETROLATUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; GANGRENE; GRAFT FAILURE; HISTOPATHOLOGY; MALE; NONHUMAN; OINTMENT; PRIORITY JOURNAL; PROPHYLAXIS; RAT; SKIN FLAP SURVIVAL; SKIN NECROSIS; TISSUE PERFUSION;

ADMINISTRATION, TOPICAL; ANIMALS; CAPSAICIN; DRUG THERAPY, COMBINATION; GRAFT SURVIVAL; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; NICOTINIC ACIDS; RATS; RATS, WISTAR; SURGICAL FLAPS;

EID: 0037334472     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PRS.0000047404.28025.C5     Document Type: Article

References (26)

1. Morris, S. F., and Taylor, G. I. The time sequence of the delay phenomenon: When is surgical delay effective? An experimental study. Plast. Reconstr. Surg. 95: 526, 1995.
2. Kerrigan, C. L., and Daniel, R. K. Pharmacologic treatment of the failing skin flap. Plast. Reconstr. Surg. 70: 541, 1982.
3. Davis, R. E., Wachholz, J. H., Jassir, D., Perlyn, C. A., and Agrama, M. H. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch. Facial Plast. Surg. 1: 27, 1999.
4. Emery, F. M., Kodey, T. R., Bomberger, R. A., and McGregor, D. B. The effect of nifedipine on skin-flap survival. Plast. Reconstr. Surg. 85: 61, 1990.
5. Shalom, A., Herbert, M., and Westreich, M. Effect of aspirin on random pattern flap survival in rats. Eur. J. Plast. Surg. 23: 21, 2000.
6. Miyawaki, T., Jackson, I. T., Bier, U. C., Andrus, L., Williams, F., and Bradford, M. The effect of capsaicin ointment on skin for the survival of a cutaneous flap. Eur. J. Plast. Surg. 24: 28, 2001.
7. 1 as a topical ointment: An experimental study of application over a rat skin flap. Ann. Plast. Surg. 40: 44, 1998.
8. Karacaoǧlan, N., and Akbaş, H. Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival. Otolaryngol. Head Neck Surg. 120: 272, 1999.
9. Folkman, J., and Klagsbrun, M. Angiogenic factors. Science 235: 442, 1987.
10. Folkman, J. Tumor angiogenesis. Adv. Cancer Res. 43: 175, 1985.
11. Kull, F. C., Jr., Brent, D. A., Parikh, I., and Cuatrecasas, P. Chemical identification of a tumor-derived angiogenic factor. Science 236: 843, 1987.
12. + channel opening and vasorelaxant properties. J. Pharmacol. Exp. Ther. 281: 253, 1997.
13. Suzuki, T., Tomizawa, N., Kamata, R., et al. A possible role of nitric oxide formation in the vasodilatation of rabbit ear artery induced by a topically applied capsaicin analogue. J. Vet. Med. Sci. 60: 691, 1998.
14. Collins, T. M., Caimi, R., Lynch, P. R., et al. The effects of nicotinamide and hyperbaric oxygen on skin flap survival. Scand. J. Plast. Reconstr. Surg. Hand Surg. 25: 5, 1991.
15. Weiner, M., and Van Eys, J. Nicotinic Acid: Nutrient Cofactor Drug. New York: Marcel Dekker, 1983.
16. McFarlane, R. M., DeYoung, G., and Henry, R. A. The design of a pedicle flap in the rat to study necrosis and its prevention. Plast. Reconstr. Surg. 35: 177, 1965.
17. Rohrich, R. J., Cherry, G. W., and Spira, M. Enhancement of skin-flap survival using nitroglycerin ointment. Plast. Reconstr. Surg. 73: 943, 1984.
18. Kerrigan, C. L. Skin flap failure: Pathophysiology. Plast. Reconstr. Surg. 72: 766, 1983.
19. Manzini, S., Perretti, F., De Benedetti, L., Pradelles, P., Maggi, C. A., and Geppetti, P. A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea pig: Involvement of substance P and calcitonin gene-related peptide release. Br. J. Pharmacol. 97: 303, 1989.
20. Smith, Y. R., Klitzman, B., Ellis, M. N., and Kull, F. C. The effects of nicotinamide on microvascular density and thermal injury in rats. J. Surg. Res. 47: 465, 1989.
21. Collins, T. M., Denish, A., Sheffield, J., Mitra, A., Stueber, K., and Smith, Y. R. Nicotinamide enhances skin flap survival. Scand. J. Plast. Reconstr. Surg. Hand Surg. 23: 177, 1989.
22. Im, M.J., and Hoopes, J. E. Improved skin flap survival with nicotinic acid and nicotinamide in rats. J. Surg. Res. 47: 453, 1989.
23. Nunez, R., Calva, E., Briones, E., and Lopez-Soriano, F. Nicotinamide coenzymes in heart and coronary blood during myocardial infarction. Am. J. Physiol. 226: 73, 1974.
24. Klein, H. H., Schaper, J., Puschmann, S., Nienaber, C., Kreuzer, H., and Schaper, W. Loss of canine myocardial nicotinamide adenine dinucleotides determined the transition from reversible to irreversible ischemic damage of myocardial cells. Basic Res. Cardiol. 76: 612, 1981.
25. Gholson, R. K. The pyridine nucleotide cycle. Nature 212: 933, 1966.
26. Seifart, H. I., Delabar, V., and Siess, M. The influence of various precursors on the concentration of energy rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival. Basic Res. Cardiol. 75: 57, 1980.