Drug-induced hepatotoxicity test using γ-glutamylcysteine synthetase knockdown rat

Toxicology Letters

Volumn 189, Issue 2, 2009, Pages 159-165

  Morita, Mayu ^a   Akai, Sho ^a   Hosomi, Hiroko ^a   Tsuneyama, Koichi ^b   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Glutathione; Idiosyncratic drug induced liver injury; Knockdown rat model

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; BILIRUBIN; DICLOFENAC; FLUTAMIDE; GLUTAMATE CYSTEINE LIGASE; SHORT HAIRPIN RNA;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG INDUCED DISEASE; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANDROGEN ANTAGONISTS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUTAMIDE; GENE SILENCING; GLUTAMATE-CYSTEINE LIGASE; HEPATITIS, TOXIC; MALE; RATS; TOXICITY TESTS;

ADENOVIRIDAE; RATTUS; RODENTIA;

EID: 67649408722     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.05.016     Document Type: Article

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