-
1
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
DOI 10.1074/jbc.273.10.5858
-
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858-5868. (Pubitemid 28124064)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.10
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
2
-
-
77649190441
-
A histone code for DNA repair
-
Scully R (2010) A histone code for DNA repair. Nat Rev Mol Cell Biol 11:164.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 164
-
-
Scully, R.1
-
3
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
DOI 10.1038/nature01446
-
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421:961-966. (Pubitemid 36288029)
-
(2003)
Nature
, vol.421
, Issue.6926
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bigneli, C.R.3
Taylor, A.M.R.4
Elledge, S.J.5
-
4
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
DOI 10.1016/j.cell.2005.09.038, PII S0092867405011657
-
Stucki M, et al. (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123:1213-1226. (Pubitemid 41821780)
-
(2005)
Cell
, vol.123
, Issue.7
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
5
-
-
30744465308
-
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
-
DOI 10.1016/j.molcel.2005.11.025, PII S1097276505018137
-
Lou Z, et al. (2006) MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21:187-200. (Pubitemid 43099935)
-
(2006)
Molecular Cell
, vol.21
, Issue.2
, pp. 187-200
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Franco, S.3
Gostissa, M.4
Rivera, M.A.5
Celeste, A.6
Manis, J.P.7
Van Deursen, J.8
Nussenzweig, A.9
Paull, T.T.10
Alt, F.W.11
Chen, J.12
-
6
-
-
58149242430
-
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
-
Xiao A, et al. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457:57-62.
-
(2009)
Nature
, vol.457
, pp. 57-62
-
-
Xiao, A.1
-
7
-
-
63849187827
-
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
-
Cook PJ, et al. (2009) Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458:591-596.
-
(2009)
Nature
, vol.458
, pp. 591-596
-
-
Cook, P.J.1
-
8
-
-
67650230540
-
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent
-
Krishnan N, et al. (2009) Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem 284:16066-16070.
-
(2009)
J Biol Chem
, vol.284
, pp. 16066-16070
-
-
Krishnan, N.1
-
9
-
-
75849153738
-
Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1
-
Campbell SJ, Edwards RA, Glover JN (2010) Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1. Structure 18:167-176.
-
(2010)
Structure
, vol.18
, pp. 167-176
-
-
Campbell, S.J.1
Edwards, R.A.2
Glover, J.N.3
-
10
-
-
0036302105
-
Identification of microcephalin, a protein implicated in determining the size of the human brain
-
DOI 10.1086/341283
-
Jackson AP, et al. (2002) Identification of microcephalin, a protein implicated in determining the size of the human brain. Am J Hum Genet 71:136-142. (Pubitemid 34734714)
-
(2002)
American Journal of Human Genetics
, vol.71
, Issue.1
, pp. 136-142
-
-
Jackson, A.P.1
Eastwood, H.2
Bell, S.M.3
Adu, J.4
Toomes, C.5
Carr, I.M.6
Roberts, E.7
Hampshire, D.J.8
Crow, Y.J.9
Mighell, A.J.10
Karbani, G.11
Jafri, H.12
Rashid, Y.13
Mueller, R.F.14
Markham, A.F.15
Woods, C.G.16
-
11
-
-
27244445051
-
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
-
DOI 10.1073/pnas.0507722102
-
Lin SY, Rai R, Li K, Xu ZX, Elledge SJ (2005) BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci USA 102:15105-15109. (Pubitemid 41513342)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.42
, pp. 15105-15109
-
-
Lin, S.-Y.1
Rai, R.2
Li, K.3
Xu, Z.-X.4
Elledge, S.J.5
-
12
-
-
33746857684
-
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
-
DOI 10.1016/j.ccr.2006.07.002, PII S1535610806002133
-
Rai R, et al. (2006) BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 10:145-157. (Pubitemid 44175904)
-
(2006)
Cancer Cell
, vol.10
, Issue.2
, pp. 145-157
-
-
Rai, R.1
Dai, H.2
Multani, A.S.3
Li, K.4
Chin, K.5
Gray, J.6
Lahad, J.P.7
Liang, J.8
Mills, G.B.9
Meric-Bernstam, F.10
Lin, S.-Y.11
-
13
-
-
33751218297
-
BRIT1/MCPH1: A guardian of genome and an enemy of tumors
-
Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin SY (2006) BRIT1/MCPH1: A guardian of genome and an enemy of tumors. Cell Cycle 5:2579-2583. (Pubitemid 44785800)
-
(2006)
Cell Cycle
, vol.5
, Issue.22
, pp. 2579-2583
-
-
Chaplet, M.1
Rai, R.2
Jackson-Bernitsas, D.3
Li, K.4
Lin, S.-Y.5
-
14
-
-
33746847691
-
Microcephalin guards against small brains, genetic instability, and cancer
-
Bartek J (2006) Microcephalin guards against small brains, genetic instability, and cancer. Cancer Cell 10:91-93.
-
(2006)
Cancer Cell
, vol.10
, pp. 91-93
-
-
Bartek, J.1
-
15
-
-
67650034511
-
BRIT1/MCPH1 links chromatin remodelling to DNA damage response
-
Peng G, et al. (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 11:865-872.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 865-872
-
-
Peng, G.1
-
16
-
-
36849000716
-
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage
-
DOI 10.1074/jbc.M705245200
-
Wood JL, Singh N, Mer G, Chen J (2007) MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 282:35416-35423. (Pubitemid 350232410)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.48
, pp. 35416-35423
-
-
Wood, J.L.1
Singh, N.2
Mer, G.3
Chen, J.4
-
17
-
-
37848999008
-
Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
-
Jeffers LJ, Coull BJ, Stack SJ, Morrison CG (2008) Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene 27:139-144.
-
(2008)
Oncogene
, vol.27
, pp. 139-144
-
-
Jeffers, L.J.1
Coull, B.J.2
Stack, S.J.3
Morrison, C.G.4
-
18
-
-
84857033669
-
Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
-
Shao Z, et al. (2012) Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. J Struct Biol 177:459-468.
-
(2012)
J Struct Biol
, vol.177
, pp. 459-468
-
-
Shao, Z.1
-
19
-
-
0142240342
-
BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting
-
DOI 10.1126/science.1088877
-
Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003) BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302:636-639. (Pubitemid 37310918)
-
(2003)
Science
, vol.302
, Issue.5645
, pp. 636-639
-
-
Manke, I.A.1
Lowery, D.M.2
Nguyen, A.3
Yaffe, M.B.4
-
20
-
-
0142147272
-
The BRCT Domain Is a Phospho-Protein Binding Domain
-
DOI 10.1126/science.1088753
-
Yu X, Chini CC, He M, Mer G, Chen J (2003) The BRCT domain is a phospho-protein binding domain. Science 302:639-642. (Pubitemid 37310919)
-
(2003)
Science
, vol.302
, Issue.5645
, pp. 639-642
-
-
Yu, X.1
Chini, C.C.S.2
He, M.3
Mer, G.4
Chen, J.5
-
21
-
-
79953020734
-
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control
-
Leung CC, Gong Z, Chen J, Glover JN (2011) Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem 286:4292-4301.
-
(2011)
J Biol Chem
, vol.286
, pp. 4292-4301
-
-
Leung, C.C.1
Gong, Z.2
Chen, J.3
Glover, J.N.4
-
22
-
-
3142608985
-
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains
-
DOI 10.1016/j.str.2004.06.002, PII S0969212604002072
-
Botuyan MV, et al. (2004) Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12:1137-1146. (Pubitemid 38900756)
-
(2004)
Structure
, vol.12
, Issue.7
, pp. 1137-1146
-
-
Botuyan, M.V.E.1
Nomine, Y.2
Yu, X.3
Juranic, N.4
Macura, S.5
Chen, J.6
Mer, G.7
-
23
-
-
2342484423
-
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: Implications for signaling
-
DOI 10.1016/S1097-2765(04)00238-2, PII S1097276504002382
-
Shiozaki EN, Gu L, Yan N, Shi Y (2004) Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: Implications for signaling. Mol Cell 14:405-412. (Pubitemid 38591411)
-
(2004)
Molecular Cell
, vol.14
, Issue.3
, pp. 405-412
-
-
Shiozaki, E.N.1
Gu, L.2
Yan, N.3
Shi, Y.4
-
24
-
-
2542490186
-
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
-
DOI 10.1038/nsmb776
-
Williams RS, Lee MS, Hau DD, Glover JN (2004) Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat Struct Mol Biol 11:519-525. (Pubitemid 38691918)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.6
, pp. 519-525
-
-
Williams, R.S.1
Lee, M.S.2
Hau, D.D.3
Glover, J.N.M.4
-
25
-
-
2542489188
-
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
-
DOI 10.1038/nsmb775
-
Clapperton JA, et al. (2004) Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol 11:512-518. (Pubitemid 38691917)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.6
, pp. 512-518
-
-
Clapperton, J.A.1
Manke, I.A.2
Lowery, D.M.3
Ho, T.4
Haire, L.F.5
Yaffe, M.B.6
Smerdon, S.J.7
-
26
-
-
48749102974
-
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
-
Kilkenny ML, et al. (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev 22:2034-2047.
-
(2008)
Genes Dev
, vol.22
, pp. 2034-2047
-
-
Kilkenny, M.L.1
-
27
-
-
77949550655
-
GammaH2A binds Brc1 to maintain genome integrity during S-phase
-
Williams JS, et al. (2010) gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J 29:1136-1148.
-
(2010)
EMBO J
, vol.29
, pp. 1136-1148
-
-
Williams, J.S.1
-
28
-
-
11144245309
-
A computational method for the analysis and prediction of protein: Phosphopeptide-binding sites
-
DOI 10.1110/ps.04964705
-
Joughin BA, Tidor B, Yaffe MB (2005) A computational method for the analysis and prediction of protein:phosphopeptide-binding sites. Protein Sci 14:131-139. (Pubitemid 40054124)
-
(2005)
Protein Science
, vol.14
, Issue.1
, pp. 131-139
-
-
Joughin, B.A.1
Tidor, B.2
Yaffe, M.B.3
-
29
-
-
4544269236
-
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
-
DOI 10.1074/jbc.C400139200
-
Xu X, Lee J, Stern DF (2004) Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem 279:34091-34094. (Pubitemid 39318029)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.33
, pp. 34091-34094
-
-
Xu, X.1
Lee, J.2
Stern, D.F.3
-
30
-
-
67649576600
-
Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
-
Tibelius A, et al. (2009) Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. J Cell Biol 185:1149-1157.
-
(2009)
J Cell Biol
, vol.185
, pp. 1149-1157
-
-
Tibelius, A.1
-
31
-
-
79960984438
-
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling
-
Passemard S, et al. (2011) VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest 121:3071-3087.
-
(2011)
J Clin Invest
, vol.121
, pp. 3071-3087
-
-
Passemard, S.1
-
32
-
-
80455177095
-
MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway
-
Gruber R, et al. (2011) MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol 13:1325-1334.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1325-1334
-
-
Gruber, R.1
-
33
-
-
67650458507
-
Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair
-
Wu X, et al. (2009) Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res 69:5531-5536.
-
(2009)
Cancer Res
, vol.69
, pp. 5531-5536
-
-
Wu, X.1
-
34
-
-
57649223685
-
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair
-
Wood JL, Liang Y, Li K, Chen J (2008) Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem 283:29586-29592.
-
(2008)
J Biol Chem
, vol.283
, pp. 29586-29592
-
-
Wood, J.L.1
Liang, Y.2
Li, K.3
Chen, J.4
-
35
-
-
80053980085
-
MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
-
Yamashita D, et al. (2011) MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II. J Cell Biol 194:841-854.
-
(2011)
J Cell Biol
, vol.194
, pp. 841-854
-
-
Yamashita, D.1
-
36
-
-
84857037143
-
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain
-
Liu J, et al. (2012) Structural mechanism of the phosphorylation- dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res 40:3898-3912.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 3898-3912
-
-
Liu, J.1
-
37
-
-
84857037148
-
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
-
Jungmichel S, et al. (2012) The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Res 40:3913-3928.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 3913-3928
-
-
Jungmichel, S.1
|