Molecular mechanism of improved structural integrity of protein in polymer based microsphere delivery system

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2403-2414

  Rawat, Sanjay ^a   Kohli, Nandita ^a   Suri, C Raman ^a   Sahoo, Debendra K ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

compactness; macromolecular crowding; molecular confinement; polyethylene glycol; protein integrity; surfactant

Indexed keywords

BOVINE SERUM ALBUMIN; CARBOXYMETHYLCELLULOSE; MICROSPHERE; POLYGLACTIN; POLYSORBATE 20;

ARTICLE; CHEMICAL INTERACTION; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; EMULSION; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MICROENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; THERMODYNAMICS; THERMOSTABILITY;

CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FREEZE DRYING; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OILS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERUM ALBUMIN, BOVINE; SURFACE-ACTIVE AGENTS; WATER;

EID: 84865973895     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2004065     Document Type: Article

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