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Volumn 23, Issue 4, 2009, Pages 486-491

20(S)-Ginsenoside rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain

Author keywords

20(S) ginsenoside Rg3; Brain ischemia; Energy metabolism; Mitochondrial permeability transition pore; Neuroprotection; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYCLOSPORIN A; GINSENOSIDE RG 3; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; CALCIUM; CARRIER PROTEIN; GINSENOSIDE; NEUROPROTECTIVE AGENT;

EID: 64549087639     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2653     Document Type: Article
Times cited : (46)

References (29)
  • 1
    • 0034668791 scopus 로고    scopus 로고
    • Mitochondrial intermembrane junctional complexes and their role in cell death
    • Crompton M. 2000. Mitochondrial intermembrane junctional complexes and their role in cell death. J Physiol 529: 11-21.
    • (2000) J Physiol , vol.529 , pp. 11-21
    • Crompton, M.1
  • 2
    • 0036141158 scopus 로고    scopus 로고
    • Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation
    • De Cristobal J, Cardenas A, Lizasoain I et al. 2002. Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation. Stroke 33: 261-267.
    • (2002) Stroke , vol.33 , pp. 261-267
    • De Cristobal, J.1    Cardenas, A.2    Lizasoain, I.3
  • 3
    • 29244470801 scopus 로고    scopus 로고
    • T- 817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons
    • Fukushima T, Koide M, Ago Y, Baba A, Matsuda T. 2006. T- 817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons. Neurochem Int 48: 124-130.
    • (2006) Neurochem Int , vol.48 , pp. 124-130
    • Fukushima, T.1    Koide, M.2    Ago, Y.3    Baba, A.4    Matsuda, T.5
  • 4
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis CN. 1997. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 54: 1-8.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 5
    • 0036478989 scopus 로고    scopus 로고
    • The permeability transition pore complex: Another view
    • Halestrap AP, McStay GP, Clarke SJ. 2002. The permeability transition pore complex: another view. Biochimie 84: 15-166.
    • (2002) Biochimie , vol.84 , pp. 15-166
    • Halestrap, A.P.1    McStay, G.P.2    Clarke, S.J.3
  • 6
    • 0033837006 scopus 로고    scopus 로고
    • The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats
    • Hsieh MT, Peng WH, Wu CR, Wang WH. 2000. The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res 14: 375-377.
    • (2000) Phytother Res , vol.14 , pp. 375-377
    • Hsieh, M.T.1    Peng, W.H.2    Wu, C.R.3    Wang, W.H.4
  • 7
    • 0344813717 scopus 로고    scopus 로고
    • Platelet activating factor antagonist activity of ginsenosides
    • Jung KY, Kim DS, Oh SR et al. 1998. Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull 21: 79-80.
    • (1998) Biol Pharm Bull , vol.21 , pp. 79-80
    • Jung, K.Y.1    Kim, D.S.2    Oh, S.R.3
  • 8
    • 15644373563 scopus 로고    scopus 로고
    • Inhibition of stress- induced plasma corticosterone levels by ginsenosides in mice: Involvement of nitric oxide
    • Kim DH, Jung JS, Suh HW et al. 1998a. Inhibition of stress- induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide. Neuroreport9: 2261-2264.
    • (1998) Neuroreport9 , pp. 2261-2264
    • Kim, D.H.1    Jung, J.S.2    Suh, H.W.3
  • 9
    • 0032587041 scopus 로고    scopus 로고
    • The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: Role of K+ channels
    • Kim ND, Kang SY, Kim MJ, Park JH, Schini-Kerth VB. 1999a. The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels. Eur J Pharmacol 367: 51-57.
    • (1999) Eur J Pharmacol , vol.367 , pp. 51-57
    • Kim, N.D.1    Kang, S.Y.2    Kim, M.J.3    Park, J.H.4    Schini-Kerth, V.B.5
  • 10
    • 0032587043 scopus 로고    scopus 로고
    • Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: Role of K+ channels
    • Kim ND, Kang SY, Park JH, Schini-Kerth VB. 1999b. Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of K+ channels. Eur J Pharmacol 367: 41-49.
    • (1999) Eur J Pharmacol , vol.367 , pp. 41-49
    • Kim, N.D.1    Kang, S.Y.2    Park, J.H.3    Schini-Kerth, V.B.4
  • 12
    • 0242492625 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 140: 661-670.
    • Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 140: 661-670.
  • 13
    • 0036386954 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons
    • Kim S, Ahn K, Oh TH Nah SY, Rhim H. 2002. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun 296: 247-254.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 247-254
    • Kim, S.1    Ahn, K.2    Oh, T.H.3    Nah, S.Y.4    Rhim, H.5
  • 14
    • 0031596324 scopus 로고    scopus 로고
    • Ginsenosides Rb1, Rg3 protect cultured rat cortical cells from glutamate- induced neurodegeneration
    • Kim YC, Kim SR, Markelonis GJ, Oh TH. 1998b. Ginsenosides Rb1, Rg3 protect cultured rat cortical cells from glutamate- induced neurodegeneration. J Neurosci Res 53: 426-432.
    • (1998) J Neurosci Res , vol.53 , pp. 426-432
    • Kim, Y.C.1    Kim, S.R.2    Markelonis, G.J.3    Oh, T.H.4
  • 15
    • 0030836532 scopus 로고    scopus 로고
    • Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: Amelioration by platelet-activating factor antagonist BN 50739
    • Kintner DB, Fitzpatrick JH Jr, Gilboe DD. 1997. Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. J Neurochem 69: 1219-1227.
    • (1997) J Neurochem , vol.69 , pp. 1219-1227
    • Kintner, D.B.1    Fitzpatrick Jr, J.H.2    Gilboe, D.D.3
  • 16
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • Kroemer G, Reed JC. 2000. Mitochondrial control of cell death. Nat Med 6: 513-519.
    • (2000) Nat Med , vol.6 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 17
    • 0032719808 scopus 로고    scopus 로고
    • Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: Evidence for an antioxidant intervention
    • Maffei Facino R, Carini M, Aldini G, Berti F, Rossoni G. 1999. Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant intervention. Planta Med 65: 614-619.
    • (1999) Planta Med , vol.65 , pp. 614-619
    • Maffei Facino, R.1    Carini, M.2    Aldini, G.3    Berti, F.4    Rossoni, G.5
  • 18
    • 0036138458 scopus 로고    scopus 로고
    • Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells
    • Park JW, Youn YC, Kwon OS, Jang YY, Han ES, Lee CS. 2002. Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells. Neurochem Int 40: 223-233.
    • (2002) Neurochem Int , vol.40 , pp. 223-233
    • Park, J.W.1    Youn, Y.C.2    Kwon, O.S.3    Jang, Y.Y.4    Han, E.S.5    Lee, C.S.6
  • 19
    • 0033556544 scopus 로고    scopus 로고
    • The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187
    • Qian T, Herman B, Lemasters JJ. 1999. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol 154: 117-125.
    • (1999) Toxicol Appl Pharmacol , vol.154 , pp. 117-125
    • Qian, T.1    Herman, B.2    Lemasters, J.J.3
  • 21
    • 34247368958 scopus 로고    scopus 로고
    • Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain
    • Takayasu Y, Nakaki J, Kawasaki T et al. 2007. Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain. J Pharmacol Sci 103: 434-437.
    • (2007) J Pharmacol Sci , vol.103 , pp. 434-437
    • Takayasu, Y.1    Nakaki, J.2    Kawasaki, T.3
  • 22
    • 0035930505 scopus 로고    scopus 로고
    • Anti-apoptotic effect of cGMP in cultured astrocytes: Inhibition by cGMP-dependent protein kinase of mitochon- drial permeable transition pore
    • Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T. 2001. Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochon- drial permeable transition pore. J Biol Chem 276: 48093-48099.
    • (2001) J Biol Chem , vol.276 , pp. 48093-48099
    • Takuma, K.1    Phuagphong, P.2    Lee, E.3    Mori, K.4    Baba, A.5    Matsuda, T.6
  • 23
    • 66749139546 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rg(3) increases ischemia- induced cell proliferation and survival in the dentate gyrus of adult gerbils
    • Tian J, Fu F. 2005. 20(S)-ginsenoside Rg(3) increases ischemia- induced cell proliferation and survival in the dentate gyrus of adult gerbils. Ann Neurol 58: S10-S11.
    • (2005) Ann Neurol , vol.58
    • Tian, J.1    Fu, F.2
  • 24
    • 11844298464 scopus 로고    scopus 로고
    • Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats
    • Tian J, Fu F, Geng M et al. 2005. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 374: 92-97.
    • (2005) Neurosci Lett , vol.374 , pp. 92-97
    • Tian, J.1    Fu, F.2    Geng, M.3
  • 25
    • 33646243771 scopus 로고    scopus 로고
    • Protective effect of 20(S)-ginsenoside Rg3 against rat cortex mitochondrial injuries induced by cerebral ischemia
    • article in Chinese
    • Tian J, Fu F, Yang J. 2006. Protective effect of 20(S)-ginsenoside Rg3 against rat cortex mitochondrial injuries induced by cerebral ischemia. Chin Pharmacol Bul l22: 220-223 (article in Chinese).
    • (2006) Chin Pharmacol Bul l , vol.22 , pp. 220-223
    • Tian, J.1    Fu, F.2    Yang, J.3
  • 26
    • 0029655506 scopus 로고    scopus 로고
    • Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
    • Wen TC, Yoshimura H, Matsuda S, Lim JH, Sakanaka M. 1996. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Acta Neuropathol 91: 15-22.
    • (1996) Acta Neuropathol , vol.91 , pp. 15-22
    • Wen, T.C.1    Yoshimura, H.2    Matsuda, S.3    Lim, J.H.4    Sakanaka, M.5
  • 27
    • 0033662614 scopus 로고    scopus 로고
    • The memory enhancing effects of a Ginkgo biloba/Panaxginseng combination in healthy middle-aged volunteers
    • Wesnes KA, Ward T, McGinty A, Petrini O. 2000. The memory enhancing effects of a Ginkgo biloba/Panaxginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl) 152: 353-361.
    • (2000) Psychopharmacology (Berl) , vol.152 , pp. 353-361
    • Wesnes, K.A.1    Ward, T.2    McGinty, A.3    Petrini, O.4
  • 28
    • 0035650950 scopus 로고    scopus 로고
    • Brief introduction of Panax ginseng C.A. Meyer
    • Yun TK. 2001. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 16Suppl: S3-S5.
    • (2001) J Korean Med Sci , vol.16 , Issue.SUPPL.
    • Yun, T.K.1
  • 29
    • 0034210123 scopus 로고    scopus 로고
    • Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats
    • Zhong YM, Nishijo H, Uwano T, Tamura R, Kawanishi K, Ono T. 2000. Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav 69: 511-525.
    • (2000) Physiol Behav , vol.69 , pp. 511-525
    • Zhong, Y.M.1    Nishijo, H.2    Uwano, T.3    Tamura, R.4    Kawanishi, K.5    Ono, T.6


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