Biomarkers of Exposure: Adducts

Molecular Epidemiology of Chronic Diseases

Volumn , Issue , 2008, Pages 111-125

  Phillips, David H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Accelerator mass spectrometry (AMS); Adduct detection methods; Aristolochic acid and renal disease; Balkan endemic nephropathy (BEN) and fungal metabolite ochratoxin A (OTA); DNA sources and biomonitoring; Exposure biomarkers adducts; P postlabelling and BPDE DNA immunoassay; Smoking related adducts

Indexed keywords

EID: 84865852064     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470725726.ch9     Document Type: Chapter

References (78)

1. Abdel-Rahman AG, Allam MF, Mansour MT et al. 2001. PAH-DNA adducts in a petrol refinery in Egypt. Eur J Cancer Prevent 10: 469-472.
2. Arlt VM. 2006. Traditional herbal medicines containing plant species of the genus Aristolochia are carcinogenic to human. Eur J Gen Mol Toxicol: http://www. swan.ac.uk/cget/ejgt/issues.htm
3. Arlt VM, Stiborova M, Schmeiser HH. 2002. Aristolochic acid as a probable human cancer hazard in herbal remedies:a review. Mutagenesis 17: 265-277.
4. Arnould JP, Pfohl-Leszkowicz A, Bach V et al. 1999. Biological monitoring exposure of workers from plant producing carbon electrodes: quantification of benzo(α)pyrene-DNA adducts in leukocytes, by a 32Ppostlabelling method and an immunoassay. Hum Exp Toxicol 18: 314-321.
5. Bak H, Autrup H, Thomsen BL et al. 2006. Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study. Int J Cancer 118: 1618-1622.
6. Beland FA, Churchwell MI, Von Tungeln LS et al. 2005. High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo(a)pyrene-DNA adducts. Chem Res Toxicol 18: 1306-1315.
7. Besaratinia A, Maas LM, Brouwer EM et al. 2000. Comparison between smoking-related DNA adduct analysis in induced sputum and peripheral blood lymphocytes. Carcinogenesis 21: 1335-1340.
8. Binkova B, Lewtas J, Miskova I et al. 1995. DNA adducts and personal air monitoring of carcinogenic polycyclic aromatic hydrocarbons in an environmentally exposed population. Carcinogenesis 16: 1037-1046.
9. Binkova B, Topinka J, Mrackova G et al. 1998. Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32Ppostlabelling. Mutat Res 416: 67-84.
10. Boogaard PJ. 2002. Use of haemoglobin adducts in exposure monitoring and risk assessment. J Chromatogr B Analyt Technol Biomed Life Sci 778: 309-322.
11. Divi RL, Beland FA, Fu PP et al. 2002. Highly sensitive chemiluminescence immunoassay for benzo(a)pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring. Carcinogenesis 23: 2043-2049.
12. Dybing E, Farmer PB, Andersen M et al. 2005. Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 43: 365-410.
13. ESCODD. 2002. Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus. Carcinogenesis 23: 2129-2133.
14. Fairbairn DW, Olive PL, O'Neill KL. 1995. The comet assay: a comprehensive review. Mutation Res 339: 37-59.
15. Farmer PB. 2004. Exposure biomarkers for the study of toxicological impact on carcinogenic processes. IARC Sci Publ 157: 71-90.
16. Farmer PB, Emeny JM (eds). 2006. Biomarkers of Carcinogen Exposure and Early Effects. ECNIS: Lodz.
17. Foiles PG, Akerkar SA, Carmella SG et al. 1991. Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers. Chem Res Toxicol 4: 364-368.
18. Friesen MD, Kaderlik K, Lin D et al. 1994. Analysis of DNA adducts of 2-amino-1-methyl-6-phenylimidazo( 4,5-b)pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectrometry: validation by comparison with 32Ppostlabeling. Chem Res Toxicol 7: 733-739.
19. Galati R, Zijno A, Crebelli R et al. 2001. Detection of antibodies to the benzo(a)pyrene diol epoxide-DNA adducts in sera from individuals exposed to low doses of polycyclic aromatic hydrocarbons. J Exp Clin Cancer Res 20: 359-364.
20. Godschalk RW, Ostertag JU, Moonen EJ et al. 1998. Aromatic DNA adducts in human white blood cells and skin after dermal application of coal tar. Cancer Epidemiol Biomarkers Prevent 7: 767-773.
21. Godschalk RW, Van Schooten FJ, Bartsch H. 2003. A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds. J Biochem Mol Biol 36: 1-11.
22. Groopman JD, Jiaqi Z, Donahue PR et al. 1992. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Cancer Res 52: 45-52.
23. Gyorffy E, Anna L, Gyori Z et al. 2004. DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and nonsmoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassay. Carcinogenesis 25: 1201-1209.
24. Haugen A, Becher G, Benestad C et al. 1986. Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Res 46: 4178-4183.
25. Hemminki K, Randerath K, Reddy MV et al. 1990. Postlabeling and immunoassay analysis of polycyclic aromatic hydrocarbons-adducts of deoxyribonucleic acid in white blood cells of foundry workers. Scand J Work Environ Health 16: 158-162.
26. Hemminki K, Soderling J, Ericson P et al. 1994. DNA adducts among personnel servicing and loading diesel vehicles. Carcinogenesis 15: 767-769.
27. Herbert R, Marcus M, Wolff MS et al. 1990. Detection of adducts of deoxyribonucleic acid in white blood cells of roofers by 32P-postlabeling. Relationship of adduct levels to measures of exposure to polycyclic aromatic hydrocarbons. Scand J Work Environ Health 16: 135-143.
28. IARC. 2004. Tobacco Smoke and Involuntary Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans No. 83. IARC: Lyon.
29. Ichiba M, Hagmar L, Rannug A et al. 1994. Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps. Carcinogenesis 15: 1347-1352.
30. Jonsson BA, Wishnok JS, Skipper PL et al. 1995. Lysine adducts between methyltetrahydrophthalic anhydride and collagen in guinea pig lung. Toxicol Appl Pharmacol 135: 156-162.
31. Kanaly RA, Hanaoka T, Sugimura H et al. 2006. Development of the adductome approach to detect DNA damage in humans. Antioxid Redox Signal 8: 993-1001.
32. Kennedy DO, Agrawal M, Shen J et al. 2005. DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. J Natl Cancer Inst 97: 127-132.
33. Lin D, Lay JO Jr, Bryant MS et al. 1994. Analysis of 4-aminobiphenyl-DNA adducts in human urinary bladder and lung by alkaline hydrolysis and negative ion gas chromatography-mass spectrometry. Environ Health Perspect 102(suppl 6): 11-16.
34. Mumford JL, Lee X, Lewtas J et al. 1993. DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality. Environ Health Perspect 99: 83-87.
35. Nielsen PS, Andreassen A, Farmer PB et al. 1996. Biomonitoring of diesel exhaust-exposed worker. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure. Toxicol Lett 86: 27-37.
36. Peluso M, Munnia A, Hoek G et al. 2005. DNA adducts and lung cancer risk: a prospective study. Cancer Res 65: 8042-8048.
37. Perera FP, Hemminki K, Gryzbowska E et al. 1992. Molecular and genetic damage in humans from environmental pollution in Poland. Nature 360: 256-258.
38. Pfohl-Leszkowicz A, Castegnaro M. 2005. Further arguments in favour of direct covalent binding of ochratoxin A (OTA) after metabolic biotransformation. Food Addit Contam 22(suppl 1): 75-87.
39. Phillips DH. 1996. DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke. Environ Health Perspect 104(suppl 3): 453-458.
40. Phillips DH. 1997. Detection of DNA modifications by the 32P-postlabelling assay. Mutation Res 378: 1-12.
41. Phillips DH. 2002. Smoking-related DNA and protein adducts in human tissues. Carcinogenesis 23: 1979-2004.
42. Phillips DH. 2005. DNA adducts as markers of exposure and risk. Mutat Res 577: 284-292.
43. Phillips DH. 2005. Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons. In The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons, Luch A (ed.). Imperial College Press: London; 137-169.
44. Phillips DH. 2007. The formation of DNA adducts. In The Cancer Handbook, Allison MR (ed.). Wiley:Chichester.
45. Phillips DH, Farmer PB. 1995. Protein and DNA adducts as biomarkers of exposure to environmental mutagens. In Environmental Mutagenesis, Phillips DH, Venitt S (eds). Bios: Oxford; 367-395.
46. Phillips DH, Hemminki K, Alhonen A et al. 1988. Monitoring occupational exposure to carcinogens:detection by 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers. Mutat Res 204: 531-541.
47. Poirier MC. 2004. Chemical-induced DNA damage and human cancer risk. Nat Rev Cancer 4: 630-637.
48. Poirier MC, Santella RM, Weston A. 2000. Carcinogen macromolecular adducts and their measurement. Carcinogenesis 21: 353-359.
49. Poirier MC, Weston A, Schoket B et al. 1998. Biomonitoring of United States Army soldiers serving in Kuwait in 1991. Cancer Epidemiol Biomarkers Prevent 7: 545-551.
50. Qian GS, Ross RK, Yu MC et al. 1994. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prevent 3: 3-10.
51. Rojas M, Cascorbi I, Alexandrov K et al. 2000. Modulation of benzo(a)pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. Carcinogenesis 21: 35-41.
52. Rothman N, Correa-Villaseñor A, Ford DP et al. 1993. Contribution of occupation and diet to white blood cell polycyclic aromatic hydrocarbon-DNA adducts in wildland firefighters. Cancer Epidemiol Biomarkers Prevent 2: 341-347.
53. Ruchirawat M, Mahidol C, Tangjarukij C et al. 2002. Exposure to genotoxins present in ambient air in Bangkok, Thailand-particle-associated polycyclic aromatic hydrocarbons and biomarkers. Sci Total Environ 287: 121-132.
54. Ruchirawat M, Settachan D, Navasumrit P et al. 2007. Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand. Toxicol Lett 168: 200-209.
55. Santella RM, Gammon M, Terry M et al. 2005. DNA adducts, DNA repair genotype/phenotype and cancer risk. Mutat Res 592: 29-35.
56. Santella RM, Perera FP, Young TL et al. 1995. Polycyclic aromatic hydrocarbon-DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione S-transferase genotype. Mutat Res 334: 117-124.
57. Scheepers PT, Coggon D, Knudsen LE et al. 2002. BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)-a study in underground mining. Toxicol Lett 134: 305-317.
58. Schilter B, Marin-Kuan M, Delatour T et al. 2005. Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity. Food Addit Contam 22(suppl 1): 88-93.
59. Schmitz OJ, Worth CC, Stach D et al. 2002. Capillary electrophoresis analysis of DNA adducts as biomarkers for carcinogenesis. Angew Chem Int Ed Engl 41: 445-448.
60. Schoket B, Doty WA, Vincze I et al. 1993. Increased sensitivity for determination of polycyclic aromatic-DNA adducts in human DNA samples by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA). Cancer Epidemiol Biomarkers Prevent 2: 349-353.
61. Schoket B, Phillips DH, Poirier MC et al. 1993. DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay. Environ Health Perspect 99: 307-309.
62. Shi Q, Wang LE, Bondy ML et al. 2004. Reduced DNA repair of benzo(a)pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. Carcinogenesis 25: 1695-700.
63. Shuker DEG, Farmer PB. 1992. Relevance of urinary DNA adducts as markers of carcinogen exposure. Chem Res Toxicol 5: 450-460.
64. Singh R, Farmer PB. 2006. Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection. Carcinogenesis 27: 178-196.
65. Skipper PL, Peng X, Soohoo CK et al. 1994. Protein adducts as biomarkers of human carcinogen exposure. Drug Metab Rev 26: 111-124.
66. SooHoo CK, Singh K, Skipper PL et al. 1994. Characterization of benzo(a)pyrene anti-diol epoxide adducts to human histones. Chem Res Toxicol 7: 134-138.
67. Strickland PT, Routledge MN, Dipple A. 1993. Methodologies for measuring carcinogen adducts in humans. Cancer Epidemiol Biomarkers Prev 2: 607-619.
68. Tang D, Phillips DH, Stampfer M et al. 2001. Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the Physicians Health Study. Cancer Res 61: 6708-6712.
69. Tornqvist M, Fred C, Haglund J et al. 2002. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B Analyt Technol Biomed Life Sci 778: 279-308.
70. Tornqvist M, Landin HH. 1995. Hemoglobin adducts for in vivo dose monitoring and cancer risk estimation. J Occup Environ Med 37: 1077-1085.
71. Turteltaub KW, Dingley KH. 1998. Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification. Toxicol Lett 102-103: 435-439.
72. Vahakangas K, Trivers G, Rowe M et al. 1985. Benzo(a)pyrene diolepoxide-DNA adducts detected by synchronous fluorescence spectrophotometry. Environ Health Perspect 62: 101-104.
73. van Schooten FJ, van Leeuwen FE, Hillebrand MJ et al. 1990. Determination of benzo(a)pyrene diol epoxide-DNA adducts in white blood cell DNA from cokeoven workers: the impact of smoking. J Natl Cancer Inst 82: 927-933.
74. Veglia F, Matullo G, Vineis P. 2003. Bulky DNA adducts and risk of cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prevent 12: 157-160.
75. Vodicka P, Tvrdik T, Osterman-Golkar S et al. 1999. An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of handlamination workers. Mutat Res 445: 205-224.
76. Weston A. 1993. Physical methods for the detection of carcinogen-DNA adducts in humans. Mutation Res 288: 19-29.
77. Wild CP, Pisani P. 1998. Carcinogen DNA and protein adducts as biomarkers of human exposure in environmental cancer epidemiology. Cancer Detect Prevent 22: 273-283.
78. Xiong P, Bondy ML, Li D et al. 2001. Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study. Cancer Res 61: 8465-8469.