DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking patients: Correlations between tissues and detection by 32P-postlabelling and immunoassay

Carcinogenesis

Volumn 25, Issue 7, 2004, Pages 1201-1209

  Gyorffy, Erika ^a   Anna, Lívia ^a   Gyori, Zoltán ^b   Segesdi, Judit ^b   Minárovits, János ^b   Soltész, Ibolya ^c   Kostič, Szilárd ^c   Csekeo, Atilla ^c   Poirier, Miriam C ^d   Schoket, Bernadette ^a  

^a Jozsef Fodor National Center for Public Health   (Hungary)

^b NATIONAL CENTER FOR EPIDEMIOLOGY   (Hungary)

^c NATIONAL KORANYI INSTITUTE OF PULMONOLOGY   (Hungary)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; CARCINOGEN; DNA; PHOSPHORUS 32; POLYCYCLIC AROMATIC HYDROCARBON;

AUTORADIOGRAPHY; BRONCHUS; CANCER CLASSIFICATION; CANCER RISK; CHEMOLUMINESCENCE; CIGARETTE SMOKING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DNA ADDUCT; DNA DAMAGE; FEMALE; GENDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; LUNG CANCER; LUNG PARENCHYMA; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVIEW;

ADULT; AGED; BRONCHI; DNA ADDUCTS; FEMALE; HUMANS; IMMUNOASSAY; LUNG; LUNG NEOPLASMS; LYMPHOCYTES; MALE; MIDDLE AGED; PHOSPHORUS RADIOISOTOPES; SMOKING;

EID: 3242794371     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh131     Document Type: Review

References (42)

1. Doll,R. and Peto,R. (1981) The Causes of Cancer. Oxford University Press, Oxford.
2. IARC (1986) Tobacco Smoking. IARC Scientific Publications, IARC, Lyon.
3. Miller,E.C. and Miller,J.A. (1981) Searches for ultimate chemical carcinogens and their reaction with cellular macromolecules. Cancer, 47, 2327-2345.
4. Pelkonen,O. and Nebert,D.W. (1982) Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol. Rev., 34, 189-222.
5. Poirier,M.C. and Beland,F.A. (1992) DNA adduct measurement and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol., 5, 749-755.
6. Phillips,D.H. and Farmer,P.B. (1995) Protein and DNA adducts as biomarkers of exposure to environmental mutagens. In Phillips,D.H. and Venitt,S. (eds), Environmental Mutagenesis. Bios Scientific Publishers Limited, Oxford, pp. 367-395.
7. Poirier,M.C., Santella,R.M. and Weston,A. (2000) Carcinogen macromolecular adducts and their measurement. Carcinogenesis, 21, 353-359.
8. 32P-postlabelling assay. Mutat. Res., 378, 1-12.
9. Weston,A., Manchester,D.K., Poirier,M.C., Choi,J.-S., Trivers,G.E., Mann,D.L. and Harris,C.C. (1989) Derivative fluorescence spectral analysis of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Chem. Res. Toxicol., 2, 104-108.
10. Godschalk,R., Nair,J., van Schooten,F.J., Risch,A., Drings,P., Kayser,K., Dienemann,H. and Bartsch,H. (2002) Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking. Carcinogenesis, 23, 2081-2086.
11. Boysen,G. and Hecht,S.S. (2003) Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutat. Res., 543, 17-30.
12. Divi,R.L., Beland,F.A., Fu,P.P., Von Tungeln,L.S., Schoket,B., Eltz,J., Rothman,N., Sinha,R. and Poirier,M.C. (2002) Highly-sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods and use in human biomonitoring. Carcinogenesis, 23, 2043-2049.
13. Phillips,D.H. (2002) Smoking-related DNA and protein adducts in human tissues. Carcinogenesis, 23, 1979-2004.
14. Wiencke,J.D. (2002) DNA adduct burden and tobacco carcinogenesis. Oncogene, 21, 7376-7391.
15. Schoket,B., Phillips,D.H., Kostic,S. and Vincze,I. (1998) Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. Carcinogenesis, 19, 841-846.
16. Schoket,B., Horkay,I., Kósa,Á., Páldeák,L., Hewer,A., Grover,P.L. and Phillips,D.H. (1990) Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture and in mouse skin and lung following topical application of coal-tar and juniper tar. J. Invest. Dermatol., 94, 241-246.
17. Phillips,D.H. and Castegnaro,M. (1999) Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis, 14, 301-315.
18. van Schooten,F.J., Hillebrand,M.J.X., Leeuwen,F.E., van Zandwijk,N., den Engelse,L. and Kriek,E. (1992) Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung. Carcinogenesis, 13, 987-993.
19. Tang,D., Santella,R.M., Blackwood,A.M., Young,T.L., Mayer,J., Jaretzki,A., Grantham,S., Tsai,W.Y. and Perera,F.P. (1995) A molecular epidemiological case-control study of lung cancer. Cancer Epidemiol. Biomarkers Prev., 4, 341-346.
20. Banaszewski,J., Szmeja,Z., Szyfter,W., Szyfter,K., Baranczewski,P. and Moller,L. (2000) Analyses of aromatic DNA adducts in laryngeal biopsies. Eur. Arch. Otorhinolaryngol., 257, 149-153.
21. Szyfter,K., Hemminki,K., Szyfter,W., Szmeja,Z., Banaszewski,J. and Yang,K. (1994) Aromatic DNA adducts in larynx biopsies and leukocytes. Carcinogenesis, 15, 2195-2199.
22. Faraglia,B., Chen,S.Y., Gammon,M.D. et al. (2003) Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke. Carcinogenesis, 24, 719-725.
23. Chen,S.Y., Wang,L.Y., Lunn,R.M., Tsai,W.Y., Lee,P.H., Lee,C.S., Ahsan,H., Zhang,Y.J., Chen,C.J. and Santella,R.M. (2002) Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. Int. J. Cancer, 99, 14-21.
24. Lee,B.M., Jang,J.J. and Kim,H.S. (1998) Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma. Cancer Lett., 125, 61-68.
25. 32P-postlabelling in human cholangiocarcinoma. Gut, 52, 586-591.
26. Phillips,D.H., Schoket,B., Hewer,A., Bailey,E., Kostic,S. and Vincze,I. (1990) Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells. Int. J. Cancer, 46, 569-575.
27. 32P-postlabelling assay. Carcinogenesis, 12, 503-508.
28. Godschalk,R.W., Maas,L.M., Van Zandwijk,N., van't Veer,L.J., Breedijk,A., Borm,P.J., Verhaert,J., Kleinjans,J.C. and van Schooten,F.J. (1998) Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers. Carcinogenesis, 19, 819-825.
29. Duell,E.J., Wiencke,J.K., Cheng,T.J., Varkonyi,A., Fa Zuo,Z., Ashok,T.D.S., Mark,E.J., Wain,J.C., Christiani,D.C. and Kelsey,K.T. (2000) Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis, 21, 963-971.
30. 32P-DNA adducts in a sample of healthy subjects. Carcinogenesis, 22, 1437-1445.
31. Schoket,B. (1999) DNA damage in humans exposed to environmental and dietary polycyclic aromatic hydrocarbons. Mutat. Res., 424, 143-153.
32. Wiencke,J.K., Thurston,S.W., Kelsey,K.T., Várkonyi,A., Wain,J.C., Mark,E.J. and Christiani,D.C. (1999) Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J. NCI, 91, 614-619.
33. 32P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA. Carcinogenesis, 14, 151-154.
34. 32P-Postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures. Mutat. Res., 378, 65-75.
35. Zhao,C., Georgellis,A., Flato,S., Palmberg,L., Thunberg,E. and Hemminki,K. (1997) DNA adducts in human nasal mucosa and white blood cells from smokers and non-smokers. Carcinogenesis, 18, 2205-2208.
36. Godschalk,R.W.L., Ostertag,J.U., Moonen,E.J.C., Neumann,H.A.M., Kleinjans,J.C.S. and van Schooten,F.J. (1998) Aromatic DNA adducts in human white blood cells and skin after dermal application of coal tar. Cancer Epidemiol. Biomarkers Prev., 7, 767-773.
37. Lewtas,J., Walsh,D., Williams,R. and Dobiás,L. (1977) Air pollution exposure-DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses. Mutat. Res., 378, 51-63.
38. Kriek,E., Rojas,M., Alexandrov,K. and Bartsch,H. (1998) Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk. Mutat. Res., 400, 215-231.
39. 32P-postlabelling and by enzyme-linked immunosorbent assay (ELISA). Environ. Health Perspect., 99, 307-309.
40. Poirier,M.C., Weston,A., Schoket,B. et al. (1998) Biomarkers of susceptibility and polycyclic aromatic hydrocarbon (PAH) exposure in United States Army soldiers. Cancer Epidemiol. Biomarkers Prev., 7, 545-551.
41. Hemminki,K., Randerath,K., Reddy,M.V., Putman,K.L., Santella,R.M., Perera,F.P., Young,T.L., Phillips,D.H., Hewer,A. and Savela,K. (1990) Postlabelling and immunoassay analysis of polycyclic aromatic hydrocarbons - adducts of deoxyribonucleic acid in white blood cells of foundry workers. Scand. J. Work Environ. Health, 16, 158-162.
42. 32P-postlabeling and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation and peroxidation. Mutat. Res., 378, 97-112.