Biomonitoring of diesel exhaust-exposed workers. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure

Toxicology Letters

Volumn 86, Issue 1, 1996, Pages 27-37

  Nielsen, Per Sabro ^a   Andreassen, Åshild ^b   Farmer, Peter B ^c   ØVrebø, Steinar ^b   Autrup, Herman ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

1 Hydroxypyrene; 32P Postlabelling; Biomonitoring; DNA adducts; HOEtVal hemoglobin adducts; PAH

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN; PYRENE DERIVATIVE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA ADDUCT; EXHAUST GAS; HUMAN; MALE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0012079876     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(96)83963-4     Document Type: Article

References (47)

1. International Agency for Research on Cancer (1989) Diesel and gasoline engine exhausts and some nitroarenes. Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 40., IARC, Lyon.
2. Gustavsson, P., Plato, N., Lidström, E.B. and Hogstedt, C. (1990) Lung cancer and exposure to diesel exhaust among bus garage workers. Scand. J. Work Environ. Health 16, 348-354.
3. Hayes, R.B., Thomas, T., Silverman, D.T., Vineis, P., Blot, W.J., Mason, T.J., Pickle, L.W., Correa, P., Fontham, E.T. and Schoenberg, J.B. (1989) Lung cancer in motor exhaust-related occupations. Am. J. Ind. Med. 16, 685-695.
4. Steenland, N.K., Silverman, D.T. and Hornung, R.W. (1990) Case-control study of lung cancer and truck driving in the Teamsters Union. Am. J. Public Health 80, 670-674.
5. Guberan, E., Usel, M., Raymond, L., Bolay, J., Fioretta, G. and Puissant, J. (1992) Increased risk for lung cancer and for cancer of the gastrointestinal tract among Geneva professional drivers. Br. J. Ind. Med. 49, 337-344.
6. Hemminki, K., Autrup, H. and Haugen, A. (1993) Environmental carcinogens: assessment of exposure and effect. In: L. Tomatis (Ed.), Indoor and Outdoor Air Pollution and Human Cancer, Springer Verlag, Berlin, pp. 89-102.
7. 32P-postlabelling assay. Carcinogenesis 13, 1053-1074.
8. Törnquist, M. and Ehrenberg, L. (1990) Approaches to risk assessment of automotive engine exhaust. In: H. Vainio, M. Sorsa and A.J. McMichael (Eds.), IARC Scientific Publications, Vol. 104, IARC, Lyon, pp. 277-287.
9. Jongeneelen, F.J., Scheepers, P.T.J., Groenendijk, A., van Aerts, L.A.G.J.M., Anzion, R.B.M., Bos, R.P. and Veenstra, S.J. (1988) Airborne concentrations, skin contamination, and urinary metabolite excretion of polycyclic aromatic hydrocarbons among paving workers exposed to coal tar derived road tars. Am. Ind. Hyg. Assoc. J. 49, 600-607.
10. 32P)cGMP and their use in assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterases. Adv. Cyclic Nucleotide Res. 10, 135-167.
11. 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis 3, 1081-1092.
12. 32P-Labeling test for DNA damage. Proc. Natl. Acad. Sci. 78, 6126-6129.
13. 32P-postlabeling analysis of aromatic carcinogen: DNA adducts. Cancer Res. 45, 5656-5662.
14. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7, 1543-1551.
15. Johnston, R.F., Pickett, S.C. and Barker, D.L. (1990) Autoradiography using storage phosphor technology. Electrophoresis 11, 355-360.
16. Törnquist, M., Osterman-Golkar, S., Kautiainen, A., Jensen, S., Farmer, P.B. and Ehrenberg, L. (1986) Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin. Carcinogenesis 7, 1519-1521.
17. Bailey, E., Farmer, P.B., Tang, Y.-S., Vangikar, H., Gray, A., Sle, D., Ings, R.M.J., Campell, B., McVie, J.G. and Dubbelman, R. (1991) Hydroxyethylation of hemoglobin by 1-(2-chloroethyl)-1-nitrosoureas. Chem. Res. Toxicol. 4, 462-466.
18. Lewtas, J. (1993) Complex mixtures of urban air pollutants: characterizing the cancer risk of polycyclic organic matter. Environ. Health Perspect. 100, 211-218.
19. Autrup, H. (1990) Carcinogen metabolism in cultured human tissues and cells. Carcinogenesis 11, 707-712.
20. 6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents. Mutat. Res. 110, 181-219.
21. Jeffrey, A.M., Santella, R.M., Wong, D., Ling-Ling, H., Heisig, V., Doskocil, G. and Ghayourmanesh, S. (1990) Metabolic activation of nitropyrenes and diesel particulate extracts. Health Effects Inst., Res. Report 34, 1990.
22. Gallagher, J.E., Jackson, M.A., George, M.H. and Lewtas, J. (1990) Dose-related differences in DNA adduct levels in rodent tissues following skin application of complex mixtures from air pollution sources. Carcinogenesis 11, 63-68.
23. Bond, J.A., Mauderly, J.L. and Wolff, R.K. (1990) Concentration- and time-dependent formation of DNA adducts in lungs of rats exposed to diesel exhaust. Toxicology 60, 127-135.
24. 32P-Postlabellling analysis of DNA adducts in the skin of mice treated with petrol and diesel engine lubricating oils and exhaust condensates. Carcinogenesis 10, 1485-1490.
25. 32P-postlabelling of aromatic DNA adducts in white blood cells from foundry workers. Mutat. Res. 204, 531-534.
26. Hemminki, K., Grzybowska, E., Chorazy, M., Twarkowska-Saucha, K., Sroczynski, J.W., Putman, K.L., Randerath, K., Phillips, D.H. and Hewer, A. (1990) Aromatic DNA adducts in white blood cells of coke workers. Int. Arch. Occup. Environ. Health 62, 467-470.
27. 32P-postlabelling. Scand. J. Work Environ. Health 16, 135-143.
28. Phillips, D.H., Schoket, B., Hewer, A., Bailey, E., Kostic, S. and Vincze, I. (1990) Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells. Int. J. Cancer 46, 569-575.
29. 32P-postlabelling assay. Carcinogenesis 12, 503-508.
30. Mustonen, R. and Hemminki, K. (1992) 7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes. Carcinogenesis 13, 1951-1955.
31. Hemminki, K., Söderling, J., Ericson, P., Norbeck, H.E. and Segerbäck, D. (1994) DNA adducts among personnel servicing and loading diesel vehicles. Carcinogenesis 15, 767-769.
32. Perera, P.P., Hemminki, K., Gryzbowska, E., Motykiewicz, G., Michalska, J., Santella, R.M., Young, T.L., Dickey, C., Brandt-Rauf, P., De Vivo, I, Blaner, W., Tsai, W.Y. and Chorazy, M. (1992) Molecular and genetic damage in humans from environmental pollution in Poland. Nature 360, 256-258.
33. Autrup, H., Vestergaard, A.B. and Okkels, H. (1995) Transplacental transfer of environmental genotoxins -benzo[a]pyrene-albumin in non-smoking women and effect of maternal GSTMI genotype. Carcinogenesis (accepted).
34. 32P-postlabeling assay. Carcinogenesis 14, 2463-2469.
35. Gallagher, J., Heinrich, U., George, M., Hendee, L., Phillips, D.H. and Lewtas, J. (1994) Formatiom of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles. Carcinogenesis 15, 1291-1299.
36. 32P-postlabelling analysis demonstrated by the selective formation and comparative analysis of nitrated-PAH-derived adducts arising from diesel particle extracts. Carcinogenesis 12, 1685-1691.
37. 32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures. Carcinogenesis 9, 1687-1693.
38. Sherson, D., Sigsgård, T., Overgaard, E., Loft, S., Poulsen, H.E. and Jongeneelen, F.J. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons and cytochrome P4501A2 activity among foundry workers. Br. J. Ind. Med. 49, 197-202.
39. Jongeneelen, F.J., van Leeuwen, F.E., Oosterink, S., Anzion, R.B.M., van der Loop, F., Bos, R.P. and van Veen, H.G. (1990) Ambient and biological monitoring of cokeoven workers: determinants of the internal dose of polycyclic aromatic hydrocarbons. Br. J. Ind. Med. 47, 454-461.
40. Burgaz, S., Borm, P.J.A. and Jongeneelen, F.J. (1992) Evaluation of urinary excretion of 1-hydrocypyrene and thioethers in workers exposed to bitumen fumes. Int. Arch. Occup. Environ. Health 63, 397-401.
41. Ferreira, M., Buchet, J.P., Burrion, J.B., Moro, J., Cupers, L., Delavignette, J. P., Jaques, J. and Lauwerys, R. (1994) Determinants of urinary thioethers, D-glucaric acid and mutagenicity after exposure to polycyclic aromatic hydrocarbons assessed by air monitoring and measurement of 1-hydroxypyrene in urine: a cross-sectional study in workers of coke and graphite-electrode-producing plants. Int. Arch. Occup. Environ. Health 65, 329-338.
42. Bailey, E., Brooks, A.G.F., Dollery, C.T., Farmer, P.B., Passingham, B.J., Sleightholm, M.A. and Yates, D.W. (1988) Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake. Arch. Toxicol. 62, 247-253.
43. Tavares, R., Ramos, P., Palminha, J., Bispo, M.A., Paz, I., Bras, A., Rueff, J., Farmer, P.B. and Bailey, E. (1994) Transplacental exposure to genotoxins. Evaluation in haemoglobin of hydroxyethylvaline adduct levels in smoking and non-smoking mothers and their newborns. Carcinogenesis 15, 1271-1274.
44. Hammond, S.K., Coghlin, J., Gann, P.H., Paul, M., Taghizadeh, K., Skipper, P.L. and Tannenbaum, S.R. (1993) Relationship between environmental tobacco smoke exposure and carcinogen-hemoglobin adduct levels in nonsmokers. J. Natl. Cancer Inst. 85, 474-478.
45. Ribeiro, L.R., Salvadori, D.M., Rios, A.C., Costa, S.L., Tates, A.D., Törnquist, M. and Natarajan, A.T. (1994) Biological monitoring of workers ocupationally exposed to ethylene oxide. Mutat. Res. 313, 81-87.
46. Filser, J.G., Denk, B., Törnquist, M., Kessler, W. and Ehrenberg, L. (1992) Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch. Toxicol. 66, 157-163.
47. Santella, R.M., Hemminki, K., Tang, D.L., Paik, M., Ottman, R., Young, T.L., Savela, K., Vodickova, L., Dickey, C., Whyatt, R. and Perera, F.P. (1993) Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hydroxypyrene in foundry workers. Cancer Epidemiol. Biomarkers Prev. 2, 59-62.