Use of DNAzymes for cancer research and therapy

Chinese Science Bulletin

Volumn 57, Issue 26, 2012, Pages 3404-3408

  Xu, ZhiJie ^a,b   Yang, LiFang ^a,b   Sun, LunQuan ^b   Cao, Ya ^a,b  

^a Central South University   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

cancer; DNAzymes; gene silencing technologies; interference strategy

Indexed keywords

EID: 84865830167     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-012-5380-z     Document Type: Review

References (37)

1. Breaker R R, Joyce G F. A DNA enzyme that cleaves RNA. Chem Biol, 1994, 1: 223-229.
2. Baum D A, Silverman S K. Deoxyribozymes: Useful DNA catalysts in vitro and in vivo. Cell Mol Life Sci, 2008, 65: 2156-2174.
3. Santoro S W, Joyce G F. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA, 1997, 94: 4262-4266.
4. Dass C R, Choong P F M. Sequence-related off-target effect of Dz13 against human tumor cells and safety in adult and fetal mice following systemic administration. Oligonucleotides, 2010, 20: 51-60.
5. Bhindi R, Fahmy R G, Lowe H C, et al. Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies. Am J Pathol, 2007, 171: 1079-1088.
6. Pecot C V, Calin G A, Coleman R L, et al. RNA interference in the clinic: Challenges and future directions. Nat Rev Cancer, 2011, 11: 59-67.
7. Yang L F, Lu Z X, Ma X Q, et al. A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene. Molecules, 2010, 15: 6127-6139.
8. Lu Z X, Ma X Q, Yang L F, et al. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett, 2008, 265: 226-238.
9. Mitchell A, Crispin R D, Sun L Q, et al. Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumor growth by DNAzymes targeting the zinc finger transcription factor EGR-1. Nucleic Acids Res, 2004, 32: 3065-3069.
10. Zeng W Z, Deng L Y, Zhou R. Experimental study of targeting MMP-9 deoxyribozyme role of adhesion and migration in human lung adenocarcinoma cancer cell (in Chinese). Chin J Lung Cancer, 2008, 11: 765-768.
11. Yang L F, Zeng W Z, Li D, et al. Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cells. Oncol Rep, 2009, 22: 121-126.
12. Min Z, Zhao H, Luo F Y, et al. IGF-II inhibitory DNAzymes inhibit the invasion and migration of hepatocarcinoma cells. Biotechnol Lett, 2011, 33: 911-917.
13. Liang Z Y, Wei S Z, Guan J, et al. DNAzyme-mediated cleavage of survivin mRNA and inhibition of the growth of PANC-1 cells. J Gastroen Hepatol, 2005, 20: 1595-1602.
14. Wiktorska M, Papiewska-Pajak L, Okruszek A, et al. DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells. Acta Biochim Pol, 2010, 57: 269-275.
15. Choi B R, Gwak J, Kwon H M, et al. Oligodeoxyribozymes that cleave β-catenin messenger RNA inhibit growth of colon cells via reduction of β-catenin response transcription. Mol Cancer Ther, 2010, 9: 1894-1902.
16. Yu S H, Wang T H, Au L C. Specific repression of mutant K-RAS by 10-23 DNAzyme: Sensitizing cancer cell to anti-cancer therapies. Biochem Biophys Res Commun, 2009, 378: 230-234.
17. Qu Y, Zhang L, Mao M, et al. Effects of DNAzymes targeting aurora kinase A on the growth of human prostate cancer. Cancer Gene Ther, 2008, 15: 517-525.
18. Zhang G, Luo X, Sumithran E, et al. Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression. Oncogene, 2006, 25: 7260-7266.
19. Wu Y P, Yu L J, Mcmahon R, et al. Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum Gene Ther, 1999, 10: 2847-2857.
20. Kabuli M, Yin J A L, Tobal K. Targeting PML/RARα transcript with DNAzymes results in reduction of proliferation and induction of apoptosis in APL cells. Hematol J, 2004, 5: 426-433.
21. Dass C R, Galloway S J, Jonathan C M, et al. Involvement of c-jun in human liposarcoma growth: Supporting data from clinical immunohistochemistry and DNAzyme efficacy. Cancer Biol Ther, 2008, 7: 1297-1301.
22. de Bock C E, Lin Z, Itoh T, et al. Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. FEBS J, 2005, 272: 3572-3582.
23. Wang Y F, Shen J N, Shang X F, et al. Ezrin mRNA target site selection for DNAzymes using secondary structure and hybridization thermodynamics. Tumor Biol, 2011, 32: 809-817.
24. Dass C R, Galloway S J, Choong P F M. Dz13, a c-Jun DNAzyme, is a potent inducer of caspase-2 activation. Oligonucleotides, 2010, 20: 137-145.
25. Quaranta V. Motility cues in the tumor microenvironment. Differentiation, 2002, 70: 590-598.
26. Stec M J, Niewiarowska J, Nawrot M, et al. DNAzyme to β1 and β3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel. J Biol Chem, 2002, 277: 6779-6787.
27. Zhang L, Gasper W J, Sanford A, et al. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res, 2002, 62: 5463-5469.
28. Zhang G S, Dass C R, Sun L Q, et al. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. J Natl Cancer Inst, 2004, 96: 683-696.
29. Baylin S B, Herman J G, Graff J R, et al. Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res, 1998, 72: 141-196.
30. Brueckner B, Lyko F. DNA methyltransferase inhibitors: Old and new drugs for an epigenetic cancer therapy. Trends Pharmacol Sci, 2004, 25: 551-554.
31. Li W, Liu Z L, Yao S Z, et al. Label-free colorimetric assay for methyl-transferase activity based on a novel methylation-responsive DNAzyme strategy. Anal Chem, 2010, 82: 1935-1941.
32. Benson V L, Khachigian L M, Lowe H C. DNAzymes and cardiovascular disease. Brit J Pharmacol, 2008, 154: 741-748.
33. Tan M L, Choong P F M, Dass C R. DNAzyme delivery systems: Getting past first base. Expert Opin Drug Del, 2009, 6: 127-138.
34. Tan M L, Dunstan D E, Friedhuber A M, et al. A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site. J Control Release, 2010, 144: 196-202.
35. Dass C R, Choong P F M, Khachigian L M. DNAzyme technology and cancer therapy: Cleave and let die. Mol Cancer Ther, 2008, 7: 243-251.
36. Chan C W S, Khachigian L M. DNAzymes and their therapeutic possibilities. Intern Med J, 2009, 39: 249-251.
37. Dass C R. Deoxyribozymes: Cleaving a path to clinical trials. Trends Pharmacol Sci, 2004, 25: 395-397.