Specific repression of mutant K-RAS by 10-23 DNAzyme: Sensitizing cancer cell to anti-cancer therapies

Biochemical and Biophysical Research Communications

Volumn 378, Issue 2, 2009, Pages 230-234

  Yu, Szu Hsien ^a   Wang, Tong Hong ^a,b   Au, Lo Chun ^a,b  

^a Institute of Biotechnology in Medicine   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Colon cancer; Combinational therapy; DNAzyme; Doxorubicin; K Ras; Mutant; Oncogenic; Radiation; Selective cleavage; Transfection

Indexed keywords

DNAZYME[10-23]; DOXORUBICIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE DERIVATIVE; RIBONUCLEASE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CANCER ADJUVANT THERAPY; CATALYSIS; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVE SITE; ENZYME REPRESSION; ENZYME SPECIFICITY; ENZYME THERAPY; HOMOZYGOSITY; HUMAN; HUMAN CELL; METASTASIS; ONCOGENE K RAS; POINT MUTATION; PRIORITY JOURNAL; RADIOSENSITIZATION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DNA, CATALYTIC; DNA, SINGLE-STRANDED; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASMS; ONCOGENE PROTEIN P21(RAS); POINT MUTATION; RNA, MESSENGER; TRANSFECTION;

EID: 57049137079     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.027     Document Type: Article

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