Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury

Journal of Controlled Release

Volumn 162, Issue 3, 2012, Pages 636-645

  Manickam, Devika S ^a   Brynskikh, Anna M ^a   Kopanic, Jennifer L ^a   Sorgen, Paul L ^a   Klyachko, Natalia L ^a,b   Batrakova, Elena V ^a   Bronich, Tatiana K ^a   Kabanov, Alexander V ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Antioxidant enzymes; Block ionomer complexes; Blood brain barrier; Cross linked nanozymes; Stroke therapy

Indexed keywords

ANTIOXIDANT ENZYME; BLOCK IONOMERS; BLOOD-BRAIN BARRIER; CROSS-LINKED NANOZYMES; STROKE THERAPY;

AMINO ACIDS; BLOCK COPOLYMERS; ENDOTHELIAL CELLS; OXYGEN; POLYETHYLENE OXIDES; SYNTHESIS (CHEMICAL); TISSUE;

POLYETHYLENE GLYCOLS;

ANTIOXIDANT; CATALASE; CATALASE NANOZYME; COPOLYMER; COPPER ZINC SUPEROXIDE DISMUTASE; COPPER ZINC SUPEROXIDE DISMUTASE NANOZYME; MACROGOL; METHOXYPOLY(ETHYLENE GLYCOL) BLOCK POLY(LYSINE); NANOPARTICLE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; CYTOTOXICITY; DENATURING GRADIENT GEL ELECTROPHORESIS; DISPERSION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXPERIMENTAL MODEL; FAST PROTEIN LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MALE; MASS SPECTROMETRY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR WEIGHT; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; REPERFUSION INJURY; SENSORIMOTOR FUNCTION; SINGLE DRUG DOSE; ZETA POTENTIAL;

ANIMALS; ANTIOXIDANTS; CATALASE; CATTLE; CELL LINE; CROSS-LINKING REAGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; POLYETHYLENE GLYCOLS; POLYLYSINE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUCCINIMIDES; SUPEROXIDE DISMUTASE;

EID: 84865811163     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.044     Document Type: Article

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