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Volumn 32, Issue 10, 2012, Pages 756-764

The genetic toxicity of methylphenidate: A review of the current literature

Author keywords

ADHD; Chromosome damage; Methylphenidate; Mutation

Indexed keywords

METHYLPHENIDATE; PHENOBARBITAL;

EID: 84865809003     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2721     Document Type: Review
Times cited : (9)

References (47)
  • 1
    • 78650259152 scopus 로고    scopus 로고
    • Attention deficit/hyperactivity disorder: a focused overview for children's environmental health researchers
    • Aguiar A, Eubig PA, Schantz SL. 2010. Attention deficit/hyperactivity disorder: a focused overview for children's environmental health researchers. Environ. Health Perspect. 118(12): 1646-1653.
    • (2010) Environ. Health Perspect. , vol.118 , Issue.12 , pp. 1646-1653
    • Aguiar, A.1    Eubig, P.A.2    Schantz, S.L.3
  • 2
    • 0004235298 scopus 로고    scopus 로고
    • American Psychiatric Association. (4th edn, text rev.). APA: Washington, DC.
    • American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders (4th edn, text rev.). APA: Washington, DC.
    • (2000) Diagnostic and Statistical Manual of Mental Disorders
  • 4
    • 53149105108 scopus 로고    scopus 로고
    • Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet
    • Bagnyukova TV, Powell CL, Pavliv O, Tryndyak VP, Pogribny IP. 2008. Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet. Brain Res. 1237: 44-51.
    • (2008) Brain Res. , vol.1237 , pp. 44-51
    • Bagnyukova, T.V.1    Powell, C.L.2    Pavliv, O.3    Tryndyak, V.P.4    Pogribny, I.P.5
  • 6
    • 2642586416 scopus 로고    scopus 로고
    • Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective
    • Bonassi S, Znaor A, Norppa H, Hagmar L. 2004. Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet. Genome Res. 104(1-4): 376-382.
    • (2004) Cytogenet. Genome Res. , vol.104 , Issue.1-4 , pp. 376-382
    • Bonassi, S.1    Znaor, A.2    Norppa, H.3    Hagmar, L.4
  • 10
    • 77249096480 scopus 로고    scopus 로고
    • Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
    • Dobrovolsky VN, Boctor SY, Twaddle NC, Doerge DR, Bishop ME, Manjanatha MG, Kimoto T, Miura D, Heflich RH, Ferguson SA. 2010. Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats. Environ. Mol. Mutagen. 51(2): 138-145.
    • (2010) Environ. Mol. Mutagen. , vol.51 , Issue.2 , pp. 138-145
    • Dobrovolsky, V.N.1    Boctor, S.Y.2    Twaddle, N.C.3    Doerge, D.R.4    Bishop, M.E.5    Manjanatha, M.G.6    Kimoto, T.7    Miura, D.8    Heflich, R.H.9    Ferguson, S.A.10
  • 11
    • 0029559109 scopus 로고
    • Experimental studies on the long-term effects of methylphenidate hydrochloride
    • Dunnick JK, Hailey JR. 1995. Experimental studies on the long-term effects of methylphenidate hydrochloride. Toxicology 103(2): 77-84.
    • (1995) Toxicology , vol.103 , Issue.2 , pp. 77-84
    • Dunnick, J.K.1    Hailey, J.R.2
  • 13
    • 1642514265 scopus 로고    scopus 로고
    • The worldwide prevalence of ADHD: is it an American condition?
    • Faraone SV, Sergeant J, Gillberg C, Biederman J. 2003. The worldwide prevalence of ADHD: is it an American condition? Wld Psychiat. 2(2): 104-113.
    • (2003) Wld Psychiat. , vol.2 , Issue.2 , pp. 104-113
    • Faraone, S.V.1    Sergeant, J.2    Gillberg, C.3    Biederman, J.4
  • 24
  • 25
    • 24644432068 scopus 로고
    • NTP toxicology and carcinogenesis studies of methylphenidate hydrochloride (CAS no. 298-59-9) in F344/N rats and B6C3F1 mice (feed studies)
    • National Toxicology Program.
    • National Toxicology Program. 1995. NTP toxicology and carcinogenesis studies of methylphenidate hydrochloride (CAS no. 298-59-9) in F344/N rats and B6C3F1 mice (feed studies). Natl. Toxicol. Program Tech. Rep. Ser. 439: 1-299.
    • (1995) Natl. Toxicol. Program Tech. Rep. Ser. , vol.439 , pp. 1-299
  • 27
    • 80051512974 scopus 로고    scopus 로고
    • Intra- and interindividual variability in lymphocyte chromosomal aberrations: implications for cancer risk assessment
    • Peters S, Portengen L, Bonassi S, Sram R, Vermeulen R. 2011. Intra- and interindividual variability in lymphocyte chromosomal aberrations: implications for cancer risk assessment. Am. J. Epidemiol. 174(4): 490-493.
    • (2011) Am. J. Epidemiol. , vol.174 , Issue.4 , pp. 490-493
    • Peters, S.1    Portengen, L.2    Bonassi, S.3    Sram, R.4    Vermeulen, R.5
  • 28
    • 0022373483 scopus 로고
    • Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells
    • Pinkel D, Thompson LH, Gray JW, Vanderlaan M. 1985. Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells. Cancer Res. 45(11 Pt 2): 5795-5798.
    • (1985) Cancer Res. , vol.45 , Issue.11 PART 2 , pp. 5795-5798
    • Pinkel, D.1    Thompson, L.H.2    Gray, J.W.3    Vanderlaan, M.4
  • 32
    • 78650110238 scopus 로고    scopus 로고
    • Impact of drugs approved for treating ADHD on the cell survival and energy metabolism: an in-vitro study in human neuronal and immune cells
    • Schmidt AJ, Krieg JC, Clement HW, Gebhardt S, Schulz E, Heiser P. 2010b. Impact of drugs approved for treating ADHD on the cell survival and energy metabolism: an in-vitro study in human neuronal and immune cells. J. Psychopharmacol. 24(12): 1829-1833.
    • (2010) J. Psychopharmacol. , vol.24 , Issue.12 , pp. 1829-1833
    • Schmidt, A.J.1    Krieg, J.C.2    Clement, H.W.3    Gebhardt, S.4    Schulz, E.5    Heiser, P.6
  • 33
    • 0035885262 scopus 로고    scopus 로고
    • Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice
    • Singh VK, Ganesh L, Cunningham ML, Shane BS. 2001. Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14, 643, at the lambdacII locus in Big Blue transgenic mice. Biochem. Pharmacol. 62(6): 685-692.
    • (2001) Biochem. Pharmacol. , vol.62 , Issue.6 , pp. 685-692
    • Singh, V.K.1    Ganesh, L.2    Cunningham, M.L.3    Shane, B.S.4
  • 36
    • 33746275239 scopus 로고    scopus 로고
    • Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test
    • Suter W, Martus HJ, Elhajouji A. 2006. Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. Mutat. Res. 607(2): 153-159.
    • (2006) Mutat. Res. , vol.607 , Issue.2 , pp. 153-159
    • Suter, W.1    Martus, H.J.2    Elhajouji, A.3
  • 38
    • 70350248020 scopus 로고    scopus 로고
    • Neurobiology of ADHD
    • Tripp G, Wickens JR. 2009. Neurobiology of ADHD. Neuropharmacology 57(7-8): 579-589.
    • (2009) Neuropharmacology , vol.57 , Issue.7-8 , pp. 579-589
    • Tripp, G.1    Wickens, J.R.2
  • 39
    • 0022967196 scopus 로고
    • Determination of the baseline sister chromatid exchange frequency in human and mouse peripheral lymphocytes using monoclonal antibodies and very low doses of bromodeoxyuridine
    • Tucker JD, Christensen ML, Strout CL, Carrano AV. 1986. Determination of the baseline sister chromatid exchange frequency in human and mouse peripheral lymphocytes using monoclonal antibodies and very low doses of bromodeoxyuridine. Cytogenet. Cell Genet. 43(1-2): 38-42.
    • (1986) Cytogenet. Cell Genet. , vol.43 , Issue.1-2 , pp. 38-42
    • Tucker, J.D.1    Christensen, M.L.2    Strout, C.L.3    Carrano, A.V.4
  • 40
    • 67650266246 scopus 로고    scopus 로고
    • Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder
    • Tucker JD, Suter W, Petibone DM, Thomas RA, Bailey NL, Zhou Y, Zhao Y, Muniz R, Kumar V. 2009. Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder. Mutat. Res. 677(1-2): 53-58.
    • (2009) Mutat. Res. , vol.677 , Issue.1-2 , pp. 53-58
    • Tucker, J.D.1    Suter, W.2    Petibone, D.M.3    Thomas, R.A.4    Bailey, N.L.5    Zhou, Y.6    Zhao, Y.7    Muniz, R.8    Kumar, V.9
  • 41
    • 34250200786 scopus 로고    scopus 로고
    • Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder?
    • Walitza S, Werner B, Romanos M, Warnke A, Gerlach M, Stopper H. 2007. Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environ. Health Perspect. 115(6): 936-940.
    • (2007) Environ. Health Perspect. , vol.115 , Issue.6 , pp. 936-940
    • Walitza, S.1    Werner, B.2    Romanos, M.3    Warnke, A.4    Gerlach, M.5    Stopper, H.6
  • 42
    • 57649219000 scopus 로고    scopus 로고
    • No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy
    • Walitza S, Kampf K, Artamonov N, Romanos M, Gnana Oli R, Wirth S, Warnke A, Gerlach M, Stopper H. 2009. No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy. Toxicol. Lett. 184(1): 38-43.
    • (2009) Toxicol. Lett. , vol.184 , Issue.1 , pp. 38-43
    • Walitza, S.1    Kampf, K.2    Artamonov, N.3    Romanos, M.4    Gnana Oli, R.5    Wirth, S.6    Warnke, A.7    Gerlach, M.8    Stopper, H.9
  • 43
    • 75949119835 scopus 로고    scopus 로고
    • Prospective follow-up studies found no chromosomal mutagenicity of methylphenidate therapy in ADHD affected children
    • Walitza S, Kampf K, Oli RG, Warnke A, Gerlach M, Stopper H. 2010. Prospective follow-up studies found no chromosomal mutagenicity of methylphenidate therapy in ADHD affected children. Toxicol. Lett. 193(1): 4-8.
    • (2010) Toxicol. Lett. , vol.193 , Issue.1 , pp. 4-8
    • Walitza, S.1    Kampf, K.2    Oli, R.G.3    Warnke, A.4    Gerlach, M.5    Stopper, H.6
  • 45
    • 75149168895 scopus 로고    scopus 로고
    • No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    • Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. 2010. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ. Mol. Mutagen. 51(1): 80-88.
    • (2010) Environ. Mol. Mutagen. , vol.51 , Issue.1 , pp. 80-88
    • Witt, K.L.1    Malarkey, D.E.2    Hobbs, C.A.3    Davis, J.P.4    Kissling, G.E.5    Caspary, W.6    Travlos, G.7    Recio, L.8
  • 46
    • 54049135708 scopus 로고    scopus 로고
    • Oxoguanine glycosylase 1 protects against methamphetamine-enhanced fetal brain oxidative DNA damage and neurodevelopmental deficits
    • Wong AW, McCallum GP, Jeng W, Wells PG. 2008. Oxoguanine glycosylase 1 protects against methamphetamine-enhanced fetal brain oxidative DNA damage and neurodevelopmental deficits. J. Neurosci. 28(36): 9047-9054.
    • (2008) J. Neurosci. , vol.28 , Issue.36 , pp. 9047-9054
    • Wong, A.W.1    McCallum, G.P.2    Jeng, W.3    Wells, P.G.4
  • 47
    • 84856004998 scopus 로고    scopus 로고
    • Stimulant medication use among U.S. children: a twelve-year perspective
    • E-pub ahead of print) doi: 10.1176/appi.ajp.2011.11030387
    • Zuvekas SH, Vitiello B. 2011. Stimulant medication use among U.S. children: a twelve-year perspective. (E-pub ahead of print) Am. J. Psychiat. doi: 10.1176/appi.ajp.2011.11030387
    • (2011) Am. J. Psychiat.
    • Zuvekas, S.H.1    Vitiello, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.