The genetic toxicology of methylphenidate hydrochloride in non-human primates

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 673, Issue 1, 2009, Pages 59-66

  Morris, Suzanne M ^a   Dobrovolsky, Vasily N ^a   Shaddock, Joseph G ^a   Mittelstaedt, Roberta A ^a   Bishop, Michelle E ^a   Manjanatha, Mugimane G ^a   Shelton, Sharon D ^a   Doerge, Daniel R ^a   Twaddle, Nathan C ^a   Chen, James J ^a   Lin, Chien Ju ^a   Paule, Merle G ^a   Slikker Jr , William ^a   Hotchkiss, Charlotte E ^b   Petibone, Dayton ^c   Tucker, James D ^c   Mattison, Donald R ^d  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Washington National Primate Research Center   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d Eunice Kennedy Shriver National Institute   (United States)

Author keywords

Chromosome aberrations; HPRT mutations; Methylphenidate; Micronuclei; Non human primates

Indexed keywords

ALANINE AMINOTRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METHYLPHENIDATE; RITALINIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BLOOD CELL COUNT; BLOOD SAMPLING; CELL MUTANT; CHROMOSOME ABERRATION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXPOSURE; ERYTHROCYTE SHAPE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC TOXICOLOGY; GENOTOXICITY; LONG TERM EXPOSURE; LYMPHOCYTE CLONE; MALE; MICRONUCLEUS; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY;

ANIMALS; BODY WEIGHT; CELLS, CULTURED; CHROMOSOME ABERRATIONS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METHYLPHENIDATE; MICRONUCLEUS TESTS; MUTATION; PRIMATES; TANDEM MASS SPECTROMETRY;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 58649104663     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.12.001     Document Type: Article

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