Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice

Environmental and Molecular Mutagenesis

Volumn 49, Issue 8, 2008, Pages 585-593

  Manjanatha, Mugimane G ^a   Shelton, Sharon D ^a   Dobrovolsky, Vasily N ^a   Shaddock, Joseph G ^a   McGarrity, Lynda G ^a   Doerge, Daniel R ^b   Twaddle, Nathan W ^b   Lin, Chien Ju ^b   Chen, James J ^b   Mattison, Donald R ^c   Morris, Suzanne M ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Hprt mutation; Methylphenidate hydrochloride; Micronucleus assay; Ritalinic acid

Indexed keywords

METHYLPHENIDATE; RITALINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; GENE MUTATION; GENOTOXICITY; KIDNEY MASS; LIVER HYPERTROPHY; LIVER WEIGHT; LYMPHOCYTE; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; ORGAN WEIGHT; PERIPHERAL LYMPHOCYTE; SEMINAL VESICLE; TESTIS WEIGHT; THYMUS;

ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIVER; MALE; METHYLPHENIDATE; MICE; MUTAGENICITY TESTS; ORGAN SIZE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; MUS;

EID: 54249167393     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20407     Document Type: Article

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