Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Sabri, Mohammed ^a,b,c   Ai, Jinglu ^a,b,c   Marsden, Philip A ^b,c   Macdonald, R Loch ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRINOGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURON SPECIFIC NUCLEAR PROTEIN; NITRIC OXIDE; SIMVASTATIN; SUPEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; BRAIN VASOSPASM; CONTROLLED STUDY; CROSS COUPLING REACTION; DIMERIZATION; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FEMALE; MALE; MICROTHROMBUS; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SUBARACHNOID HEMORRHAGE; TREATMENT DURATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG SCREENING; GENETICS; LACTOSE OPERON; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; TRANSGENIC MOUSE;

MUS;

ANIMALS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; SIMVASTATIN; SUBARACHNOID HEMORRHAGE;

EID: 79952030438     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017062     Document Type: Article

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