Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 273-283

  Rajanarendar, E ^a   Nagi Reddy, M ^a   Rama Krishna, S ^a   Rama Murthy, K ^a   Reddy, Y N ^a   Rajam, M V ^b  

^a KAKATIYA UNIVERSITY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Analgesic activity; Anti inflammatory activity; Antimicrobial activity; Isoxazolyl chromeno 2,3 d pyrimidin 4 ones; Isoxazolyl pyrimido 4,5 b quinolines

Indexed keywords

2 METHYL 3 [3 METHYL 5 (2 PHENYL 1 ETHENYL) 4 ISOXAZOLYL] 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 METHYL 3 [3 METHYL 5 [ 2 (4 METHYLPHENYL) 1 ETHENYL] 4 ISOXAZOLYL] 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2,3 DIHYDRO 7 METHOXY 3 (3 METHYL 5 STYRYLISOXAZOL 4 YL)CHROMENO[2,3 D]PYRIMIDIN 4 ONE; 2,3 DIHYDRO 7 METHYL 3 (3 METHYL 5 STYRYLISOXAZOL 4 YL)CHROMENO[2,3 D]PYRIMIDIN 4 ONE; 3 [3 METHYL 5 (2 PHENYL 1 ETHENYL) 4 ISOXAZOLYL] 3,4 DIHYDRO 2H CHROMENO [2,3 D]PYRIMIDIN 4 ONE; 3 [5 [2 (4 METHOXYPHENYL) 1 ETHENYL] 3 METHYL 4 ISOXAZOLYL] 2 METHYL 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 7 BROMO 3 [3 METHYL 5 [2 (4 METHOXYPHENYL) 1 ETHENYL] 4 ISOXAZOLYL] 3,4 DIHYDRO 2H CHROMENO[2,3 D]PYRIMIDIN 4 ONE; 7 CHLORO 2 METHYL 3 [3 METHYL 5 (2 PHENYL 1 ETHENYL) 4 ISOXAZOLYL] 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 7 CHLORO 2 METHYL 3 [3 METHYL 5 [2 (4 METHYLPHENYL) 1 ETHENYL] 4 ISOXAZOLYL] 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 7 CHLORO 3 [3 METHYL 5 [2 (4 METHYLPHENYL) 1 ETHENYL] 4 ISOXAZOLYL] 3,4 DIHYDRO 2H CHROMENO[2,3 D]PYRIMIDIN 4 ONE; 7 CHLORO 3 [5 [2 (4 METHOXYPHENYL) 1 ETHENYL] 3 METHYL 4 ISOXAZOLYL] 2 METHYL 3,4 DIHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 7,9 DIBROMO 3 [3 METHYL 5 (2 PHENYL 1 ETHENYL) 4 ISOXAZOLYL] 3,4 DIHYDRO 2H CHROMENO[2,3 D]PYRIMIDIN 4 ONE; 7,9 DICHLORO 3 [3 METHYL 5 (2 PHENYL 1 ETHENYL) 4 ISOXAZOLYL] 3,4 DIHYDRO 2H CHROMENO[2,3 D]PYRIMIDIN 4 ONE; CIPROFLOXACIN; INDOMETACIN; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ANALGESIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; INFRARED SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANALGESICS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; BACTERIA; BEHAVIOR, ANIMAL; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; EDEMA; FUNGI; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; PYRIMIDINONES; QUINOLINES; RATS;

EID: 84865767172     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.029     Document Type: Article

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