Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 149-153

  Rajanarendar, E ^a   Nagi Reddy, M ^a   Rama Murthy, K ^a   Surendar, P ^a   Reddy, R N ^a   Reddy, Y N ^a  

^a KAKATIYA UNIVERSITY   (India)

Author keywords

Anticancer activity; Michael addition; Phenylmethylene bis isoxazolo 4,5 b azepine; Reductive cyclization

Indexed keywords

ANTINEOPLASTIC AGENT; AZEPINE DERIVATIVE; BIS AZEPINE; CHALCONE DERIVATIVE; CISPLATIN; DIBENZOISOXAZOLO[2,3 A]AZEPINE; ISOXAZOLO[4,5 B]AZEPINE; ISOXAZOLO[4,5 C]AZEPINE; ISOXAZOLO[5,4 B]AZEPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MICHAEL ADDITION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTINEOPLASTIC AGENTS; AZEPINES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CISPLATIN; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHANOL; MICE; MODELS, CHEMICAL; NEOPLASMS; SPECTROPHOTOMETRY, INFRARED; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84655162288     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.044     Document Type: Article

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