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Volumn 42, Issue 9, 2012, Pages 2285-2289

T-cell exhaustion due to persistent antigen: Quantity not quality?

Author keywords

Antigen presenting cells; CD8+ T cells; Dendritic cells; Immune regulation; Immunopathology

Indexed keywords

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; VIRUS INFECTION; VIRUS REPLICATION;

EID: 84865765985     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242852     Document Type: Note
Times cited : (16)

References (39)
  • 1
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • Virgin, H. W., Wherry, E. J. and Ahmed, R., Redefining chronic viral infection. Cell 2009. 138: 30-50.
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 2
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E. J., T cell exhaustion. Nat. Immunol. 2011. 12: 492-499.
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 3
    • 68249152608 scopus 로고    scopus 로고
    • Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    • Tinoco, R., Alcalde, V., Yang, Y., Sauer, K. and Zuniga, E. I., Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 2009. 31: 145-157.
    • (2009) Immunity , vol.31 , pp. 145-157
    • Tinoco, R.1    Alcalde, V.2    Yang, Y.3    Sauer, K.4    Zuniga, E.I.5
  • 4
    • 77951258833 scopus 로고    scopus 로고
    • Features of responding T cells in cancer and chronic infection
    • Kim, P. S. and Ahmed, R., Features of responding T cells in cancer and chronic infection. Curr. Opin. Immunol. 2010. 22: 223-230.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 223-230
    • Kim, P.S.1    Ahmed, R.2
  • 5
    • 63449103666 scopus 로고    scopus 로고
    • Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection
    • Li, Q., Skinner, P. J., Ha, S. J., Duan, L., Mattila, T. L., Hage, A., White, C. et al., Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science 2009. 323: 1726-1729.
    • (2009) Science , vol.323 , pp. 1726-1729
    • Li, Q.1    Skinner, P.J.2    Ha, S.J.3    Duan, L.4    Mattila, T.L.5    Hage, A.6    White, C.7
  • 6
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. and Ahmed, R., Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 2003. 77: 4911-4927.
    • (2003) J. Virol. , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der Most, R.4    Ahmed, R.5
  • 7
    • 41149160165 scopus 로고    scopus 로고
    • Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
    • Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., Karrer, U. et al., Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J. Virol. 2008. 82: 3391-3404.
    • (2008) J. Virol. , vol.82 , pp. 3391-3404
    • Rehr, M.1    Cahenzli, J.2    Haas, A.3    Price, D.A.4    Gostick, E.5    Huber, M.6    Karrer, U.7
  • 8
    • 44449096577 scopus 로고    scopus 로고
    • Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    • Streeck, H., Brumme, Z. L., Anastario, M., Cohen, K. W., Jolin, J. S., Meier, A., Brumme, C. J. et al., Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med. 2008. 5: e100.
    • (2008) PLoS Med. , vol.5
    • Streeck, H.1    Brumme, Z.L.2    Anastario, M.3    Cohen, K.W.4    Jolin, J.S.5    Meier, A.6    Brumme, C.J.7
  • 9
    • 66149123225 scopus 로고    scopus 로고
    • Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
    • Blattman, J. N., Wherry, E. J., Ha, S. J., van der Most, R. G. and Ahmed, R., Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J. Virol. 2009. 83: 4386-4394.
    • (2009) J. Virol. , vol.83 , pp. 4386-4394
    • Blattman, J.N.1    Wherry, E.J.2    Ha, S.J.3    van der Most, R.G.4    Ahmed, R.5
  • 10
    • 34848852256 scopus 로고    scopus 로고
    • Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
    • Mueller, S. N., Matloubian, M., Clemens, D. M., Sharpe, A. H., Freeman, G. J., Gangappa, S., Larsen, C. P. et al., Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl. Acad. Sci. USA 2007. 104: 15430-15435.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 15430-15435
    • Mueller, S.N.1    Matloubian, M.2    Clemens, D.M.3    Sharpe, A.H.4    Freeman, G.J.5    Gangappa, S.6    Larsen, C.P.7
  • 11
    • 84865781144 scopus 로고    scopus 로고
    • Antigen amount dictates CD8(+) T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell
    • Richter, K., Brocker, T. and Oxenius, A., Antigen amount dictates CD8(+) T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell. Eur. J. Immunol. 2012. 42: 2290-2304.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 2290-2304
    • Richter, K.1    Brocker, T.2    Oxenius, A.3
  • 12
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 13
    • 15444366815 scopus 로고    scopus 로고
    • Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells
    • Probst, H. C. and van den Broek, M., Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J. Immunol. 2005. 174: 3920-3924.
    • (2005) J. Immunol. , vol.174 , pp. 3920-3924
    • Probst, H.C.1    van den Broek, M.2
  • 14
    • 33745205112 scopus 로고    scopus 로고
    • Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    • Brooks, D. G., McGavern, D. B. and Oldstone, M. B., Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. J. Clin. Invest. 2006. 116: 1675-1685.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1675-1685
    • Brooks, D.G.1    McGavern, D.B.2    Oldstone, M.B.3
  • 15
    • 6344293677 scopus 로고    scopus 로고
    • The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo
    • Cannarile, M. A., Decanis, N., van Meerwijk, J. P. and Brocker, T., The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo. J. Immunol. 2004. 173: 4799-4805.
    • (2004) J. Immunol. , vol.173 , pp. 4799-4805
    • Cannarile, M.A.1    Decanis, N.2    van Meerwijk, J.P.3    Brocker, T.4
  • 16
    • 33748933183 scopus 로고    scopus 로고
    • Hepatitis C virus entry: molecular biology and clinical implications
    • Barth, H., Liang, T. J. and Baumert, T. F., Hepatitis C virus entry: molecular biology and clinical implications. Hepatology 2006. 44: 527-535.
    • (2006) Hepatology , vol.44 , pp. 527-535
    • Barth, H.1    Liang, T.J.2    Baumert, T.F.3
  • 17
    • 0028262942 scopus 로고
    • Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions
    • Lohler, J., Gossmann, J., Kratzberg, T. and Lehmann-Grube, F., Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions. Lab. Invest. 1994. 70: 263-278.
    • (1994) Lab. Invest. , vol.70 , pp. 263-278
    • Lohler, J.1    Gossmann, J.2    Kratzberg, T.3    Lehmann-Grube, F.4
  • 18
    • 84861144540 scopus 로고    scopus 로고
    • Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection
    • Wilson, E. B., Kidani, Y., Elsaesser, H., Barnard, J., Raff, L., Karp, C. L., Bensinger, S. et al., Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host Microbe 2012. 11: 481-491.
    • (2012) Cell Host Microbe , vol.11 , pp. 481-491
    • Wilson, E.B.1    Kidani, Y.2    Elsaesser, H.3    Barnard, J.4    Raff, L.5    Karp, C.L.6    Bensinger, S.7
  • 20
    • 79952582607 scopus 로고    scopus 로고
    • Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence
    • Sullivan, B. M., Emonet, S. F., Welch, M. J., Lee, A. M., Campbell, K. P., de la Torre, J. C. and Oldstone, M. B., Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence. Proc. Natl. Acad. Sci. USA 2011. 108: 2969-2974.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2969-2974
    • Sullivan, B.M.1    Emonet, S.F.2    Welch, M.J.3    Lee, A.M.4    Campbell, K.P.5    de la Torre, J.C.6    Oldstone, M.B.7
  • 21
    • 84862280795 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection
    • Macal, M., Lewis, G. M., Kunz, S., Flavell, R., Harker, J. A. and Zuniga, E. I., Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host Microbe 2012. 11: 617-630.
    • (2012) Cell Host Microbe , vol.11 , pp. 617-630
    • Macal, M.1    Lewis, G.M.2    Kunz, S.3    Flavell, R.4    Harker, J.A.5    Zuniga, E.I.6
  • 22
    • 53349143044 scopus 로고    scopus 로고
    • Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    • Zuniga, E. I., Liou, L. Y., Mack, L., Mendoza, M. and Oldstone, M. B., Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe 2008. 4: 374-386.
    • (2008) Cell Host Microbe , vol.4 , pp. 374-386
    • Zuniga, E.I.1    Liou, L.Y.2    Mack, L.3    Mendoza, M.4    Oldstone, M.B.5
  • 23
    • 33645797125 scopus 로고    scopus 로고
    • CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion
    • Aichele, P., Unsoeld, H., Koschella, M., Schweier, O., Kalinke, U. and Vucikuja, S., CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J. Immunol. 2006. 176: 4525-4529.
    • (2006) J. Immunol. , vol.176 , pp. 4525-4529
    • Aichele, P.1    Unsoeld, H.2    Koschella, M.3    Schweier, O.4    Kalinke, U.5    Vucikuja, S.6
  • 24
    • 84862294199 scopus 로고    scopus 로고
    • Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
    • Wang, Y., Swiecki, M., Cella, M., Alber, G., Schreiber, R. D., Gilfillan, S. and Colonna, M., Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe 2012. 11: 631-642.
    • (2012) Cell Host Microbe , vol.11 , pp. 631-642
    • Wang, Y.1    Swiecki, M.2    Cella, M.3    Alber, G.4    Schreiber, R.D.5    Gilfillan, S.6    Colonna, M.7
  • 25
    • 77954966127 scopus 로고    scopus 로고
    • PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
    • Mueller, S. N., Vanguri, V. K., Ha, S. J., West, E. E., Keir, M. E., Glickman, J. N., Sharpe, A. H. et al., PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J. Clin. Invest. 2010. 120: 2508-2515.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2508-2515
    • Mueller, S.N.1    Vanguri, V.K.2    Ha, S.J.3    West, E.E.4    Keir, M.E.5    Glickman, J.N.6    Sharpe, A.H.7
  • 26
    • 0033524949 scopus 로고    scopus 로고
    • The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    • Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J., Dalton, S. L., Wu, J., Pittet, J. F. et al., The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999. 96: 319-328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.2    Kawakatsu, H.3    Griffiths, M.J.4    Dalton, S.L.5    Wu, J.6    Pittet, J.F.7
  • 27
    • 34548208943 scopus 로고    scopus 로고
    • Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    • Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y. et al., Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 2007. 449: 361-365.
    • (2007) Nature , vol.449 , pp. 361-365
    • Travis, M.A.1    Reizis, B.2    Melton, A.C.3    Masteller, E.4    Tang, Q.5    Proctor, J.M.6    Wang, Y.7
  • 28
    • 79959993129 scopus 로고    scopus 로고
    • Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alphavbeta8-mediated activation of TGF-beta
    • Kitamura, H., Cambier, S., Somanath, S., Barker, T., Minagawa, S., Markovics, J., Goodsell, A. et al., Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alphavbeta8-mediated activation of TGF-beta. J. Clin. Invest. 2011. 121: 2863-2875.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2863-2875
    • Kitamura, H.1    Cambier, S.2    Somanath, S.3    Barker, T.4    Minagawa, S.5    Markovics, J.6    Goodsell, A.7
  • 29
    • 77950571116 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in HIV infection: striking a delicate balance
    • Fitzgerald-Bocarsly, P. and Jacobs, E. S., Plasmacytoid dendritic cells in HIV infection: striking a delicate balance. J. Leukoc. Biol. 2010. 87: 609-620.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 609-620
    • Fitzgerald-Bocarsly, P.1    Jacobs, E.S.2
  • 30
    • 67449119121 scopus 로고    scopus 로고
    • Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice
    • Lee, L. N., Burke, S., Montoya, M. and Borrow, P., Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice. J. Immunol. 2009. 182: 7178-7189.
    • (2009) J. Immunol. , vol.182 , pp. 7178-7189
    • Lee, L.N.1    Burke, S.2    Montoya, M.3    Borrow, P.4
  • 31
    • 0038717548 scopus 로고    scopus 로고
    • Immunopathogenesis and immunotherapy in AIDS virus infections
    • Letvin, N. L. and Walker, B. D., Immunopathogenesis and immunotherapy in AIDS virus infections. Nat. Med. 2003. 9: 861-866.
    • (2003) Nat. Med. , vol.9 , pp. 861-866
    • Letvin, N.L.1    Walker, B.D.2
  • 32
    • 34247328511 scopus 로고    scopus 로고
    • Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
    • Shin, H., Blackburn, S. D., Blattman, J. N. and Wherry, E. J., Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. J. Exp. Med. 2007. 204: 941-949.
    • (2007) J. Exp. Med. , vol.204 , pp. 941-949
    • Shin, H.1    Blackburn, S.D.2    Blattman, J.N.3    Wherry, E.J.4
  • 34
    • 84855999478 scopus 로고    scopus 로고
    • Natural killer cells act as rheostats modulating antiviral T cells
    • Waggoner, S. N., Cornberg, M., Selin, L. K. and Welsh, R. M., Natural killer cells act as rheostats modulating antiviral T cells. Nature 2012. 481: 394-398.
    • (2012) Nature , vol.481 , pp. 394-398
    • Waggoner, S.N.1    Cornberg, M.2    Selin, L.K.3    Welsh, R.M.4
  • 35
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser, H., Sauer, K. and Brooks, D. G., IL-21 is required to control chronic viral infection. Science 2009. 324: 1569-1572.
    • (2009) Science , vol.324 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 36
    • 67649234772 scopus 로고    scopus 로고
    • IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    • Frohlich, A., Kisielow, J., Schmitz, I., Freigang, S., Shamshiev, A. T., Weber, J., Marsland, B. J. et al., IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 2009. 324: 1576-1580.
    • (2009) Science , vol.324 , pp. 1576-1580
    • Frohlich, A.1    Kisielow, J.2    Schmitz, I.3    Freigang, S.4    Shamshiev, A.T.5    Weber, J.6    Marsland, B.J.7
  • 37
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi, J. S., Du, M. and Zajac, A. J., A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009. 324: 1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 38
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker, J. A., Lewis, G. M., Mack, L. and Zuniga, E. I., Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 2011. 334: 825-829.
    • (2011) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 39
    • 84862291971 scopus 로고    scopus 로고
    • Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection
    • Walsh, K. B., Teijaro, J. R., Zuniga, E. I., Welch, M. J., Fremgen, D. M., Blackburn, S. D., von Tiehl, K. F. et al., Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe 2012. 11: 643-653.
    • (2012) Cell Host Microbe , vol.11 , pp. 643-653
    • Walsh, K.B.1    Teijaro, J.R.2    Zuniga, E.I.3    Welch, M.J.4    Fremgen, D.M.5    Blackburn, S.D.6    von Tiehl, K.F.7


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