Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: Protonation of tyr188 is necessary to prompt metal release

Biochemistry

Volumn 51, Issue 35, 2012, Pages 7017-7027

  Mujika, J I ^a   Escribano, B ^b   Akhmatskaya, E ^b   Ugalde, J M ^a   Lopez, X ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BCAM BASQUE CENTER FOR APPLIED MATHEMATICS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SERUM; CONFORMATIONAL CHANGE; ENDOSOMAL PH; HINGE-BENDING MOTIONS; METAL RELEASE; MOLECULAR DYNAMICS SIMULATIONS; PROTONATED; PROTONATION STATE; RECEPTOR-MEDIATED ENDOCYTOSIS; WHOLE PROCESS;

ALUMINUM; BODY FLUIDS; IRON COMPOUNDS; METALS; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; PROTEINS;

PROTONATION;

ALUMINUM; IRON; TRANSFERRIN;

ARTICLE; CONFORMATIONAL TRANSITION; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT; TRANSFERRIN BLOOD LEVEL;

ALUMINUM; HUMANS; IRON; MOLECULAR DYNAMICS SIMULATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONFORMATION; PROTONS; TRANSFERRIN; TYROSINE;

EID: 84865752254     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300584p     Document Type: Article

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