The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin

FEBS Letters

Volumn 573, Issue 1-3, 2004, Pages 181-185

  Sun, Xuesong ^a   Sun, Hongzhe ^a   Ge, Ruiguang ^a   Richter, Megan ^b   Woodworth, Robert C ^b   Mason, Anne B ^b   He, Qing Yu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Anion binding; BHK, baby hamster kidney cells; Heteronuclear single quantum coherence nuclear magnetic resonance; hTF, human serum transferrin; hTF 2N, recombinant N lobe of human transferrin comprising residues 1 337; pK a; Transferrin; Tyrosine

Indexed keywords

ANION; ARSENIC ACID; ISOPROTEIN; LIGAND; LYSINE; SULFATE; TRANSFERRIN; TYROSINE; APOPROTEIN; ARSENIC ACID DERIVATIVE; IRON;

ARTICLE; BINDING SITE; CHELATION; HUMAN; IRON BINDING CAPACITY; IRON KINETICS; NUCLEAR MAGNETIC RESONANCE; PH; PKA; PRIORITY JOURNAL; PROTEIN INTERACTION; TITRIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

CRICETINAE;

ANIONS; APOPROTEINS; ARSENATES; BINDING SITES; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; LIGANDS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; SULFATES; TITRIMETRY; TRANSFERRIN; TYROSINE;

EID: 4344645436     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.07.076     Document Type: Article

References (21)

1. Evans R.W., Crawley J.B., Joannou C.L., Sharma N.D. Iron proteins. Bullen J.J., Griffiths E. Iron and Infection: Molecular, Physiological and Clinical Aspects. 1999;27-86 John Wiley and Sons, Chichester
2. Aisen P. Transferrin, the Transferrin Receptor, and the Uptake of Iron by Cells. Sigel A., Sigel H. Iron Transport and Storage in Microorganisms, Plants and Animals. 1998;585-631 Marcel Dekker, Inc, New York
3. Baker E.N. Adv. Inorg. Chem. 41:1994;389-463
4. MacGillivray R.T.A., Moore S.A., Chen J., Anderson B.F., et al. Biochemistry. 37:1998;7919-7928
5. Jeffrey P.D., Bewley M.C., MacGillivray R.T.A., Mason A.B., et al. Biochemistry. 37:1998;13978-13986
6. He Q.-Y., Mason A.B. Molecular aspects of release of iron from transferrin. Templeton D.M. Molecular and Cellular Iron Transport. 2001;95-123 Marcel Dekker, Inc., New York
7. Adams T.E., Mason A.B., He Q.-Y., Halbrooks P.J., et al. J. Biol. Chem. 278:2003;6027-6033
8. Zak O., Ikuta K., Aisen P. Biochemistry. 41:2002;7416-7423
9. Ikuta K., Zak O., Aisen P. Int. J. Biochem. Cell Biol. 36:2004;340-352
10. He Q.-Y., Mason A.B., Woodworth R.C., Tam B.M., et al. Biochemistry. 36:1997;14853-14860
11. He Q.-Y., Mason A.B., Tam B.M., MacGillivray R.T.A., et al. Biochemistry. 38:1999;9704-9711
12. He Q.-Y., Mason A.B., Woodworth R.C., Tam B.M., et al. J. Biol. Chem. 273:1998;17018-17024
13. Cheng Y.G., Mason A.B., Woodworth R.C. Biochemistry. 34:1995;14879-14884
14. Dewan J.C., Mikami B., Hirose M., Sacchettini J.C. Biochemistry. 32:1993;11963-11968
15. Davis J.P., Zhou M.M., Van Etten R.L. Biochemistry. 33:1994;1278-1286
16. Li Y.K., Kuliopulos A., Mildvan A.S., Talalay P. Biochemistry. 32:1993;1816-1824
17. Fujii S., Akasaka K., Hatano H. Biochemistry. 20:1981;518-523
18. Canioni P., Cozzone P.J. FEBS Lett. 97:1979;353-357
19. Woodworth R.C., Butcher N.D., Brown S.A., Brown-Mason A. Biochemistry. 26:1987;3115-3120
20. Clarkson J., Smith D.A. FEBS Lett. 503:2001;30-34
21. Rinaldo D., Field M.J. Biophys. J. 85:2003;3485-3501