Disubstituted thiourea derivatives and their activity on CNS: Synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 205-213

  Stefanska, Joanna ^a   Szulczyk, Daniel ^a   Koziol, Anna E ^b   Miroslaw, Barbara ^b   Kedzierska, Ewa ^c   Fidecka, Sylwia ^c   Busonera, Bernardetta ^d   Sanna, Giuseppina ^d   Giliberti, Gabriele ^d   La Colla, Paolo ^d   Struga, Marta ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Antibacterial activity; Antitumor activity; CNS activity 5 HT system connection; Cytotoxicity; Thiourea derivatives of 1,2,4 triazole; X ray crystal structure analysis

Indexed keywords

1 (2 BROMOPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (2 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (3 BROMOPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (3 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (3,4 DICHLOROPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (4 BROMOPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (4 CHLOROPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (4 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (4 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 (4 METHYLPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 BENZOYL 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1 PHENYL 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 1,2,4 TRIAZOLE DERIVATIVE; 5 AMINO N (2 ETHOXYCARBONYL) 1H 1,2,4 TRIAZOLE 1 CARBOTHIOAMIDE; 5 AMINO N (2 METHYLALLYL) 1H 1,2,4 TRIAZOLE 1 CARBOTHIOAMIDE; 5 AMINO N (2 PHENYLETHYL) 1H 1,2,3 TRIAZOLE 1 CARBOTHIOAMIDE; 5 AMINO N BENZYL 1H 1,2,4 TRIAZOLE 1 CARBOTHIOAMIDE; CAMPTOTECIN; OPIATE RECEPTOR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

1 (4 IODOPHENYL) 3 (1H 1,2,4 TRIAZOL 3 YL)THIOUREA; 5 AMINO N CYCLOHEXYL 1H 1,2,4 TRIAZOLE 1 CARBOTHIOAMIDE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE COCCI; HUMAN; HUMAN CELL; LD 50; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SEROTONINERGIC SYSTEM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; X RAY ANALYSIS;

ANIMALS; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; BACTERIA; BEHAVIOR, ANIMAL; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; FUNGI; HUMANS; MALE; MICE; MOTOR ACTIVITY; THIOUREA;

EID: 84865748271     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.020     Document Type: Article

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