Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis

Cell Death and Disease

Volumn 3, Issue 8, 2012, Pages

  Roy, A ^a   Basak, N P ^a   Banerjee, S ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

Akt; EZH2; LIMK1; Megakaryocyte; Notch1

Indexed keywords

COFILIN; LIM KINASE 1; NOTCH1 RECEPTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR EZH2; ACTIN DEPOLYMERIZING FACTOR; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; LIM KINASE; LIMK1 PROTEIN, HUMAN; P4HB PROTEIN, HUMAN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN DISULFIDE ISOMERASE; TRANSCRIPTION FACTOR;

ACTIN FILAMENT; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; IMMUNOPRECIPITATION; MEGAKARYOPOIESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CELL STRAIN K 562; CHEMISTRY; CYTOLOGY; CYTOPLASM; HUMAN; MEGAKARYOCYTE; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; UPREGULATION;

ACTIN DEPOLYMERIZING FACTORS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYTOPLASM; DNA-BINDING PROTEINS; HUMANS; K562 CELLS; LIM KINASES; MEGAKARYOCYTES; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN DISULFIDE-ISOMERASES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84865733342     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.119     Document Type: Article

References (48)

1. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-776. (Pubitemid 29291335)
2. Dumortier A, Wilson A, MacDonald HR, Radtke F. Paradigms of notch signaling in mammals. Int J Hematol 2005; 82: 277-284. (Pubitemid 43329736)
3. Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A et al. Human ligands of the Notch receptor. Am J Pathol 1999; 154: 785-794. (Pubitemid 29122597)
4. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M et al. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol 2000; 20: 6913-6922.
5. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998; 393: 382-386. (Pubitemid 28269713)
6. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 2007; 27: 89-99. (Pubitemid 47096801)
7. Radtke F, Wilson A, MacDonald HR. Notch signaling in T- and B-cell development. Curr Opin Immunol 2004; 16: 174-179. (Pubitemid 38328718)
8. Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 2003; 18: 675-685. (Pubitemid 36588584)
9. Sugimoto A, Yamamoto M, Suzuki M, Inoue T, Nakamura S, Motoda R et al. Delta-4 Notch ligand promotes erythroid differentiation of human umbilical cord blood CD34+ cells. Exp Hematol 2006; 34: 424-432.
10. Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell 2008; 3: 314-326.
11. Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK et al. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood 2011; 118: 1264-1273.
12. Watts KL, Delaney C, Humphries RK, Bernstein ID, Kiem HP. Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells. Blood 2010; 116: 5859-5866.
13. Lam LT, Ronchini C, Norton J, Capobianco AJ, Bresnick EH. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by notch-1. J Biol Chem 2000; 275: 19676-19684. (Pubitemid 30441563)
14. Ishiko E, Matsumura I, Ezoe S, Gale K, Ishiko J, Satoh Y et al. Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1. J Biol Chem 2005; 280: 4929-4939. (Pubitemid 40288668)
15. Poirault-Chassac S, Six E, Catelain C, Lavergne M, Villeval JL, Vainchenker W et al. Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation. Blood 2010; 116: 5670-5678.
16. Meurette O, Stylianou S, Rock R, Collu GM, Gilmore AP, Brennan K. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res 2009; 69: 5015-5022.
17. Calzavara E, Chiaramonte R, Cesana D, Basile A, Sherbet GV, Comi P. Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells in vitro. J Cell Biochem 2008; 103: 1405-1412. (Pubitemid 351490710)
18. Nakao T, Geddis AE, Fox NE, Kaushansky K. PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1). Cell Cycle 2008; 7: 257-266. (Pubitemid 351366527)
19. Tanaka M, Kirito K, Kashii Y, Uchida M, Watanabe T, Endo H et al. Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling. J Biol Chem 2001; 276: 15082-15089.
20. Guerriero R, Parolini I, Testa U, Samoggia P, Petrucci E, Sargiacomo M et al. Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes. J Cell Sci 2006; 119: 744-752.
21. Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood 2011; 117: 5963-5974.
22. Ye JY, Chan GC, Qiao L, Lian Q, Meng FY, Luo XQ et al. Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway. Haematologica 2010; 95: 1745-1753.
23. Ringrose L, Paro R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 2004; 38: 413-443. (Pubitemid 40013734)
24. Su IH, Basavaraj A, Krutchinsky AN, Hobert O, Ullrich A, Chait BT et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 2003; 4: 124-131. (Pubitemid 36193013)
25. Visser HP, Gunster MJ, Kluin-Nelemans HC, Manders EM, Raaphorst FM, Meijer CJ et al. The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Br J Haematol 2001; 112: 950-958. (Pubitemid 32322920)
26. Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R et al. Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 2005; 121: 425-436. (Pubitemid 40692302)
27. Jacquelin B, Kortulewski T, Vaigot P, Pawlik A, Gruel G, Alibert O et al. Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin alphaIIb-expressing cells. Blood 2005; 106: 1965-1974. (Pubitemid 41291707)
28. Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tonnissen ER et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010; 42: 665-667.
29. Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T et al. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood 2011; 118: 6553-6561.
30. Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S et al. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol 2009; 29: 5168-5180.
31. Hobert O, Jallal B, Ullrich A. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol 1996; 16: 3066-3073. (Pubitemid 26163376)
32. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998; 393: 809-812. (Pubitemid 28299495)
33. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 1997; 16: 3965-3973. (Pubitemid 27281012)
34. Gutierrez L, Tsukamoto S, Suzuki M, Yamamoto-Mukai H, Yamamoto M, Philipsen S et al. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood 2008; 111: 4375-4385.
35. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995; 81: 695-704.
36. Starck J, Weiss-Gayet M, Gonnet C, Guyot B, Vicat JM, Morle F. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood 2010; 116: 4795-4805.
37. Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci USA 1995; 92: 8690-8694.
38. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA 1996; 93: 12355-12358. (Pubitemid 26367147)
39. Gao Z, Huang Z, Olivey HE, Gurbuxani S, Crispino JD, Svensson EC. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 2010; 29: 457-468.
40. Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L. The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders. Eur J Hum Genet 2000; 8: 174-180. (Pubitemid 30189860)
41. Essex DW, Chen K, Swiatkowska M. Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane. Blood 1995; 86: 2168-2173.
42. Essex DW, Li M. Protein disulphide isomerase mediates platelet aggregation and secretion. Br J Haematol 1999; 104: 448-454. (Pubitemid 29119264)
43. Bryant RJ, Winder SJ, Cross SS, Hamdy FC, Cunliffe VT. The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells. Prostate 2008; 68: 255-263. (Pubitemid 351273054)
44. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 2005; 310: 306-310. (Pubitemid 41457195)
45. Chen TW, Hwang SM, Chu IM, Hsu SC, Hsieh TB, Yao CL. Characterization and transplantation of induced megakaryocytes from hematopoietic stem cells for rapid platelet recovery by a two-step serum-free procedure. Exp Hematol 2009; 37: 1330-1339; e1335.
46. Chen H, Tu SW, Hsieh JT. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem 2005; 280: 22437-22444. (Pubitemid 40827899)
47. Bienvenut WV, Deon C, Pasquarello C, Campbell JM, Sanchez JC, Vestal ML et al. Matrix-assisted laser desorption/ionization-tandem mass spectrometry with high resolution and sensitivity for identification and characterization of proteins. Proteomics 2002; 2: 868-876. (Pubitemid 34803970)
48. Bhattacharya D, Mukhopadhyay D, Chakrabarti A. Hemoglobin depletion from red blood cell cytosol reveals new proteins in 2-D gel-based proteomics study. Proteomics Clin Appl 2007; 1: 561-564.