Therapeutic upregulation of class a scavenger receptor member 5 inhibits tumor growth and metastasis

Cancer Science

Volumn 103, Issue 9, 2012, Pages 1631-1639

  Yan, Nv ^a   Zhang, Shuang ^a   Yang, Yang ^a   Cheng, Lin ^a   Li, Can ^a   Dai, Lixia ^a   Dai, Lei ^a   Zhang, Xiaomei ^a   Fan, Ping ^a   Tian, Hongwei ^a   Wang, Ruibo ^a   Chen, Xiaolei ^a   Su, Xiaolan ^a   Li, Yiming ^a   Zhang, Junfeng ^a   Du, Tao ^a   Wei, Yuquan ^a   Deng, Hongxin ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS A SCAVENGER RECEPTOR MEMBER 5; CYCLIN B1; CYCLIN D1; FOCAL ADHESION KINASE; GELATINASE B; PROTEIN KINASE B; SCAVENGER RECEPTOR A; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GLIOMA; HUMAN; HUMAN CELL; LUNG METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SCARA 5 GENE; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASMS; PLASMIDS; SCAVENGER RECEPTORS, CLASS A; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR BURDEN; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865703601     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02350.x     Document Type: Article

References (36)

1. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904.
2. Ma L, Reinhardt F, Pan E et al. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 2010; 28: 341-7.
3. Bandyopadhyay S, Wang Y, Zhan R et al. The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer. Cancer Res 2006; 66: 11983-90.
4. Shevde LA, Welch DR. Metastasis suppressor pathways: an evolving paradigm. Cancer Lett 2003; 198: 1-20.
5. Jiang Y, Oliver P, Davies KE, Platt N. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J Biol Chem 2006; 281: 11834-45.
6. Li JY, Paragas N, Ned RM et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell 2009; 16: 35-46.
7. Huang J, Zheng DL, Qin FS et al. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest 2010; 120: 223-41.
8. Halder J, Lin YG, Merritt WM et al. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res 2007; 67: 10976-83.
9. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52: 2745-56.
10. Shaw G, Morse S, Ararat M, Graham FL. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J 2002; 16: 869-71.
11. Schuebel KE, Chen W, Cope L et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007; 3: e157.
12. Tan SM-L, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J Pharmacol Exp Ther 2010; 334: 285-93.
13. Liu J, Huang R, Lin D et al. Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-α ligands induces apoptosis on human myeloid leukemia cells in vitro. Ann Oncol 2005; 16: 455-9.
14. Wan Y, Huang A, Yang Y et al. A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth. Int J Oncol 2010; 36: 1121-8.
15. Kawasaki K, Smith RS Jr, Hsieh CM, Sun J, Chao J, Liao JK. Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis. Mol Cell Biol 2003; 23: 5726-37.
16. Deng H, Jiang Q, Yang Y et al. Intravenous liposomal delivery of the short hairpin RNAs against Plk1 controls the growth of established human hepatocellular carcinoma. Cancer Biol Ther 2011; 11: 401-9.
17. Wang H, Shen W, Huang H et al. Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res 2003; 63: 4315.
18. Yung W, Tepper S, Young D. Diffuse bone marrow metastasis by glioblastoma: Premortem diagnosis by peroxidase-antiperoxidase staining for glial fibrillary acidic protein. Ann Neurol 1983; 14: 581-5.
19. Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD. Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 1995; 83: 308-15.
20. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 453-8.
21. Ramesh R, Saeki T, Templeton NS et al. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001; 3: 337-50.
22. Zelphati O, Szoka FC. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A 1996; 93: 11493-8.
23. Sangaré L, Morisset R, Omri A, Ravaoarinoro M. Incorporation rates, stabilities, cytotoxicities and release of liposomal tetracycline and doxycycline in human serum. J Antimicrob Chemother 1998; 42: 831-4.
24. Jiao X, Wang RYH, Qiu Q, Alter HJ, Shih J. Enhanced hepatitis C virus NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes. J Gen Virol 2004; 85: 1545-53.
25. Christensen CL, Gjetting T, Poulsen TT, Cramer F, Roth JA, Poulsen HS. Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay. Clin Cancer Res 2010; 16: 2308-19.
26. Lu C, Stewart D, Ji L, Ramesh R, Jayachandran G, Erasmus J. A phase I trial of intravenous therapy with tumor suppressor Fus1-nanoparticles for recurrent/metastatic lung cancer. J Clin Oncol 2009; 27: 00-00.
27. Hiscox S, Barnfather P, Hayes E et al. Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells. Breast Cancer Res Treat 2011; 125: 659-69.
28. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. The role of focal-adhesion kinase in cancer: a new therapeutic opportunity. Nat Rev Cancer 2005; 5: 505-15.
29. Hecker TP, Gladson CL. Focal adhesion kinase in cancer. Front Biosci 2003; 8: 705-14.
30. Chen JY, Tang YA, Huang SM et al. A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res 2011; 71: 473-83.
31. Golubovskaya VM, Cance W. Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci 2010; 15: 901-12.
32. Xu W, Doshi A, Lei M, Eck MJ. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molecular Cell 1999; 3: 629-38.
33. Groner B, Lucks P, Borghouts C The function of Stat3 in tumor cells and their microenvironment. Semin Cell Dev Biol 2008; 19: 341-50.
34. Xie T, Huang FJ, Aldape KD et al. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 2006; 66: 3188-96.
35. Niu G, Wright KL, Huang M et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21: 2000-8.
36. Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003; 3: 46-54.