Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats

European Urology

Volumn 62, Issue 4, 2012, Pages 704-712

  Yoshikawa, Satoru ^a   Oguchi, Tomohiko ^a   Funahashi, Yasuhito ^a   De Groat, William C ^a   Yoshimura, Naoki ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bladder pain syndrome; Glycine; Glycine transporter; Overactive bladder; Rat; Spinal cord

Indexed keywords

ALX 1393; CYCLOPHOSPHAMIDE; GLYCINE RECEPTOR; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 2; MESSENGER RNA; PROTEIN INHIBITOR; RESINIFERATOXIN; SARCOSINE; STRYCHNINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CYSTOMETRY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; FEMALE; FREEZING; INHIBITION KINETICS; LICKING; MICTURITION; NOCICEPTION; NONHUMAN; OVERACTIVE BLADDER; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMALS; DITERPENES; FEMALE; FREEZING REACTION, CATALEPTIC; GLYCINE AGENTS; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; NOCICEPTIVE PAIN; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SARCOSINE; SERINE; SPINAL CORD; STRYCHNINE; URINARY BLADDER, OVERACTIVE; URINATION;

EID: 84865701534     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2012.01.044     Document Type: Article

References (28)

1. N. Yoshimura, and M.B. Chancellor Current and future pharmacological treatment for overactive bladder J Urol 168 2002 1897 1913
2. L. Birder, W. de Groat, I. Mills, J. Morrison, K. Thor, and M. Drake Neural control of the lower urinary tract: peripheral and spinal mechanisms Neurourol Urodyn 29 2010 128 139
3. N. Yoshimura, and L.A. Birder Interstitial cystitis and related painful bladder syndromes: pathophysiology P.J. Pasricha, W.D. Willis, G.F. Gebhart, Chronic abdominal and visceral pain: theory and practice. 2007 Informa Healthcare USA New York, NY 495 520
4. H.U. Zeilhofer The glycinergic control of spinal pain processing Cell Mol Life Sci 62 2005 2027 2035
5. M. Miyazato, K. Sugaya, S. Nishijima, K. Kadekawa, S. Ashimine, and Y. Ogawa Intrathecal or dietary glycine inhibits bladder and urethral activity in rats with spinal cord injury J Urol 174 2005 2397 2400
6. M. Miyazato, K. Sugaya, and S. Nishijima Changes of bladder activity and glycine levels in the lumbosacral cord after partial bladder outlet obstruction in rats Int J Urol 15 2008 843 847
7. S. Nishijima, K. Sugaya, T. Fukuda, M. Miyazato, S. Ashimine, and Y. Ogawa Serum amino acids as indicators of cerebrospinal neuronal activity in patients with micturition disorders Int J Urol 13 2006 1479 1483
8. V. Eulenburg, W. Armsen, H. Betz, and J. Gomeza Glycine transporters: essential regulators of neurotransmission Trends Biochem Sci 30 2005 325 333
9. F. Zafra, C. Aragon, L. Olivares, N.C. Danbolt, C. Gimenez, and J. Storm-Mathisen Glycine transporters are differentially expressed among CNS cells J Neurosci 15 1995 3952 3969
10. F. Zafra, J. Gomeza, L. Olivares, C. Aragon, and C. Gimenez Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS Eur J Neurosci 7 1995 1342 1352
11. H. Mohler, D. Boison, P. Singer, J. Feldon, M. Pauly-Evers, and B.K. Yee Glycine transporter 1 as a potential therapeutic target for schizophrenia- related symptoms: evidence from genetically modified mouse models and pharmacological inhibition Biochem Pharmacol 81 2011 1065 1077
12. D. Boulay, P. Pichat, and G. Dargazanli Characterization of SSR 103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia Pharmacol Biochem Behav 91 2008 47 58
13. D. Manahan-Vaughan, V. Wildforster, and C. Thomsen Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1) Eur J Neurosci 28 2008 1342 1350
14. T. Dohi, K. Morita, T. Kitayama, N. Motoyama, and N. Morioka Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain Pharmacol Ther 123 2009 54 79
15. Y. Haranishi, K. Hara, T. Terada, S. Nakamura, and T. Sata The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model Anesth Analg 110 2010 615 621
16. C. Saitoh, M.B. Chancellor, W.C. de Groat, and N. Yoshimura Effects of intravesical instillation of resiniferatoxin on bladder function and nociceptive behavior in freely moving, conscious rats J Urol 179 2008 359 364
17. M.V. Centeno, A. Mutso, M. Millecamps, and A.V. Apkarian Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor Pain 145 2009 176 183
18. M. Miyazato, K. Sugaya, S. Nishijima, K. Ashitomi, T. Hatano, and Y. Ogawa Inhibitory effect of intrathecal glycine on the micturition reflex in normal and spinal cord injury rats Exp Neurol 183 2003 232 240
19. K.J. Whitehead, S.M. Pearce, G. Walker, H. Sundaram, D. Hill, and N.G. Bowery Positive N-methyl-D-aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in vivo Neuroscience 126 2004 381 390
20. J.W. Johnson, and P. Ascher Glycine potentiates the NMDA response in cultured mouse brain neurons Nature 325 1987 529 531
21. Y. Nong, Y.Q. Huang, and W. Ju Glycine binding primes NMDA receptor internalization Nature 422 2003 302 307
22. G. Brasnjo, and T.S. Otis Glycine transporters not only take out the garbage, they recycle Neuron 40 2003 667 669
23. F. Jursky, and N. Nelson Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor J Neurochem 64 1995 1026 1033
24. J. Grudzinska, R. Schemm, and S. Haeger The beta subunit determines the ligand binding properties of synaptic glycine receptors Neuron 45 2005 727 739
25. H. Betz, D. Langosch, and W. Hoch Structure and expression of inhibitory glycine receptors Adv Exp Med Biol 287 1991 421 429
26. H. Hermanns, U. Muth-Selbach, and R. Williams Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain Neurosci Lett 445 2008 214 219
27. G.E. Tsai, and P.Y. Lin Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis Curr Pharm Des 16 2010 522 537
28. H.Y. Lane, C.H. Lin, Y.J. Huang, C.H. Liao, Y.C. Chang, and G.E. Tsai A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia Int J Neuropsychopharmacol 13 2010 451 460