The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model

Anesthesia and Analgesia

Volumn 110, Issue 2, 2010, Pages 615-621

  Haranishi, Yasunori ^a   Hara, Koji ^a   Terada, Tadanori ^a   Nakamura, Seiya ^b   Sata, Takeyoshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALX 1393; ANTINOCICEPTIVE AGENT; GLYCINE TRANSPORTER 2; NEUROTRANSMITTER TRANSPORTER; STRYCHNINE; UNCLASSIFIED DRUG; ANALGESIC AGENT; DRUG DERIVATIVE; GLYCINE TRANSPORTER; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CATHETER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EXPERIMENTAL TEST; FORMALIN TEST; HOT PLATE TEST; MALE; MECHANICAL STIMULATION; MOTOR PERFORMANCE; NOCICEPTION; NONHUMAN; PAIN; PAW PRESSURE; PRIORITY JOURNAL; RAT; ROTAROD TEST; STIMULATION; TAIL FLICK TEST; THERMAL STIMULATION; ACUTE DISEASE; ANIMAL; DRUG ANTAGONISM; INTRASPINAL DRUG ADMINISTRATION; PAIN ASSESSMENT; PAIN THRESHOLD; SPRAGUE DAWLEY RAT;

ACUTE DISEASE; ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; INJECTIONS, SPINAL; MALE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST; SERINE; STRYCHNINE;

EID: 76249084398     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181c7ebbb     Document Type: Article

References (28)

1. Zeilhofer HU. The glycinergic control of spinal pain processing [Review]. Cell Mol Life Sci 2005;62:2027-2035
2. Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989;37:111-123
3. Sorkin LS, Puig S. Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain 1996;68: 283-292
4. Sherman SE, Luo L, Dostrovsky JO. Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus. J Neurophysiol 1997;78:628-637
5. Huang W, Simpson RK. Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. Neurol Res 2000;22:160-164
6. Eulenburg V, Armsen W, Betz H, Gomeza J. Glycine transporters: essential regulators of neurotransmission [Review]. Trends Biochem Sci 2005;30:325-333
7. Jursky F, Nelson N. Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem 1995;64:1026-1033
8. Brasnjo G, Otis TS. Glycine transporters not only take out the garbage, they recycle [Review]. Neuron 2003;40:667-669
9. Tanabe M, Takasu K, Yamaguchi S, Kodama D, Ono H. Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. Anesthesiology 2008; 108:929-937
10. Morita K, Motoyama N, Kitayama T, Morioka N, Kifune K, Dohi T. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther 2008;326:633-645
11. Hermanns H, Muth-Selbach U, Williams R, Krug S, Lipfert P, Werdehausen R, Braun S, Bauer I. Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain. Neurosci Lett 2008;445:214-219
12. Luccini E, Raiteri L. Mechanisms of [(3)H]glycine release from mouse spinal cord synaptosomes selectively labeled through GLYT2 transporters. J Neurochem 2007;103:2439-2448
13. Xu TX, Gong N, Xu TL. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. Neuroreport 2005;16: 1227-1231
14. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976;17:1031-1036
15. Randall LO, Selitto J. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn 1957;4: 409-419
16. Powell JJ, Todd AJ. Light and electron microscope study of GABA-immunoreactive neurones in lamina III of rat spinal cord. J Comp Neurol 1992;315:125-136
17. Narikawa K, Furue H, Kumamoto E, Yoshimura M. In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulation. J Neurophysiol 2000;84:2171-2174
18. Lin Q, Peng Y, Willis WD. Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray. Brain Res 1994;654:286-302
19. Antal M, Petkó M, Polgár E, Heizmann CW, Storm-Mathisen J. Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla. Neuroscience 1996;73:509-518
20. Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG. Positive N-methyl-d-aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in vivo. Neuroscience 2004;126:381-390
21. Bradaïa A, Schlichter R, Trouslard J. Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol 2004;559:169-186
22. Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992;51:5-17
23. Coderre TJ, Fundytus ME, McKenna JE, Dalal S, Melzack R. The formalin test: a validation of the weighted-scores method of behavioural pain rating. Pain 1993;54:43-50
24. Yaksh TL. Preclinical models of nociception. In: Yaksh TL, Lynch C, Zapol WM, Maze M, Biebuyck JF, Saidman LJ, eds. Anesthesia: biologic foundations. Vol I. Philadelphia: Lippincott-Raven, 1997: 685-718
25. Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU. PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci 2002;5:34-40
26. Gomeza J, Ohno K, Hülsmann S, Armsen W, Eulenburg V, Richter DW, Laube B, Betz H. Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron 2003;40:797-806
27. Hara K, Yanagihara N, Minami K, Hirano H, Sata T, Shigematsu A, Izumi F. Dual effects of intravenous anesthetics on the function of norepinephrine transporters. Anesthesiology 2000; 93:1329-1335
28. Hara K, Minami K, Ueno S, Toyohira Y, Tsutsui M, Shigematsu A, Yanagihara N. Up-regulation of noradrenaline transporter in response to prolonged exposure to ketamine. Naunyn Schmiedebergs Arch Pharmacol 2002;365:406-412