In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia

Journal of Pediatric Hematology/Oncology

Volumn 33, Issue 8, 2011, Pages 617-621

  Ln, Ramya ^a   Doble, Mukesh ^b   Rekha, V P B ^c   Pulicherla, K K ^c  

^a ACHARYA NAGARJUNA UNIVERSITY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^c RVR JC COLLEGE OF ENGINEERING   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINASE; ASPARAGINE; ENZYME VARIANT; GLUTAMINASE; GLUTAMINE; MUTANT PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; ENERGY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ENGINEERING; LIGAND BINDING; MOLECULAR DOCKING; PECTOBACTERIUM CAROTOVORUM; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ASPARAGINASE; ASPARAGINE; CATALYTIC DOMAIN; CHILD; COMPUTER SIMULATION; DRUG DESIGN; GLUTAMINASE; GLUTAMINE; HUMANS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN ENGINEERING;

EID: 80455131078     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31822aa4ec     Document Type: Article

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