The combination regimen of Idarubicin and Taxotere is effective against human drug-resistant leukemic cell lines

Anticancer Research

Volumn 22, Issue 3, 2002, Pages 1361-1368

  Majlessipour, F ^a   Avramis, I A ^a   Kwock, R ^a   Weinberg, K I ^a   Avramis, V I ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Ara C resistance; Collateral sensitivity; Idarubicin; Leukemia; Taxotere

Indexed keywords

CASPASE 3; DOCETAXEL; IDARUBICIN; PROTEIN BCL 2;

ARTICLE; CANCER RESISTANCE; CONCENTRATION RESPONSE; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ASPARAGINASE; CASPASE 3; CASPASES; CELL SURVIVAL; CLONE CELLS; CYTARABINE; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; IDARUBICIN; LEUKEMIA, T-CELL; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0036324014     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. The genetic origin of drug resistance in neoplasms: Implications for systemic therapy
2. Effects of Bcl-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells
3. Clinical relevance of Bcl-2 overexpression in childhood acute lymphoblastic leukemia
4. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
5. Bcl-2 family members in childhood acute lymphoblastic leukemia: Relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome
6. Bcl-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance
7. Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: A Children's Cancer Group Study
8. In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia
9. Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines
10. Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation
11. L, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia
12. Taxol binds to cellular microtubules
13. Promotion of microtubule assembly in vitro by taxol
14. Taxol stabilizes microtubules in mouse fibroblast cells
15. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
16. Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
17. Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro
18. Remission induction therapy of untreated acute myeloid leukemia using a non-cytarabine-containing regimen of idarubicin, etoposide, and carboplatin
19. Comparison of idarubicin to daunomycin in a randomized multidrug treatment of childhood acute lymphoblastic leukemia at first bone marrow relapse: A report from the Children's Cancer Group
20. Idarubicin, high-dose cytarabine, and etoposide for induction of remission in acute leukemia
21. Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells
22. Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine arabinoside, and induce apoptosis independent of other antiapoptotic proteins
23. Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture
24. Development of a double-resistant human leukemia model to cytosine arabinoside and L-asparaginase: Evaluation of cross-resistance to other treatment modalities
25. Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs
26. Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells
27. Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis
28. Apoptosis. The role of the endonuclease
29. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
30. DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair
31. Bcl-2 and the regulation of programmed cell death
32. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumorigenesis and resistance to chemotherapy
33. Inactivation of Bcl-2 by phosphorylation
34. Serine-70 is one of the critical sites for drug-induced Bcl-2 phosphorylation in cancer cells
35. Docetaxel
36. Taxane-based three-drug combination in metastatic and adjuvant treatment of breast cancer
37. Compilation of phase I and II trial data of docetaxel and doxorubicin in the treatment of advanced breast cancer and other malignancies
38. Epidoxorubicin and docetaxel as first-line chemotherapy in patients with advanced breast cancer: A multicentric phase I-II study