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Volumn 10, Issue 37, 2012, Pages 7545-7551

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds

(7) O'Connell, Kieron M G a Beckmann, Henning S G a Laraia, Luca a Horsley, Helen T b Bender, Andreas a Venkitaraman, Ashok R a Spring, David R a

a UNIVERSITY OF CAMBRIDGE (United Kingdom)

b UCB PHARMA (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; CANCER CELL LINES; CHEMICAL SPACE; DIVERSITY-ORIENTED SYNTHESIS; LINEAR PRECURSORS; MACROCYCLIC COMPOUNDS; MACROCYCLICS; MODULAR APPROACH; PROOF OF PRINCIPLES; STRUCTURAL CLASS; TWO-DIRECTIONAL;

BIOACTIVITY; CELL CULTURE; CHEMICAL ANALYSIS;

CHEMICAL COMPOUNDS;

AMIDE; ANTINEOPLASTIC AGENT; MACROCYCLIC COMPOUND; MALEIMIDE DERIVATIVE;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROCYCLIC COMPOUNDS; MALEIMIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865676018 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c2ob26272j Document Type: Article

Times cited : (30)

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